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Using Genetics to Identify Hereditary Colorectal Polyposis and Cancer Syndromes in Your Patient.
Curr Gastroenterol Rep. 2015 Oct; 17(10):463.CG

Abstract

The majority of patients with colorectal polyps and cancer do not have a Mendelian cause of the disease. Age, lifestyle, and environmental factors interact with complex genetic traits to contribute to the etiology. However, approximately 5-10 % of patients with colorectal cancer (CRC) and more than 40 % of patients meeting specific clinical features of the hereditary polyposis syndromes have a discoverable, actionable genetic cause which will significantly alter their medical management.

Authors+Show Affiliations

Section of Gastroenterology, Department of Veterans Affairs, Louis Stokes Cleveland Medical Center, Cleveland, 44106, OH, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26292665

Citation

Macaron, Carole, et al. "Using Genetics to Identify Hereditary Colorectal Polyposis and Cancer Syndromes in Your Patient." Current Gastroenterology Reports, vol. 17, no. 10, 2015, p. 463.
Macaron C, Heald B, Burke CA. Using Genetics to Identify Hereditary Colorectal Polyposis and Cancer Syndromes in Your Patient. Curr Gastroenterol Rep. 2015;17(10):463.
Macaron, C., Heald, B., & Burke, C. A. (2015). Using Genetics to Identify Hereditary Colorectal Polyposis and Cancer Syndromes in Your Patient. Current Gastroenterology Reports, 17(10), 463. https://doi.org/10.1007/s11894-015-0463-z
Macaron C, Heald B, Burke CA. Using Genetics to Identify Hereditary Colorectal Polyposis and Cancer Syndromes in Your Patient. Curr Gastroenterol Rep. 2015;17(10):463. PubMed PMID: 26292665.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Using Genetics to Identify Hereditary Colorectal Polyposis and Cancer Syndromes in Your Patient. AU - Macaron,Carole, AU - Heald,Brandie, AU - Burke,Carol A, PY - 2015/8/22/entrez PY - 2015/8/22/pubmed PY - 2016/5/10/medline SP - 463 EP - 463 JF - Current gastroenterology reports JO - Curr Gastroenterol Rep VL - 17 IS - 10 N2 - The majority of patients with colorectal polyps and cancer do not have a Mendelian cause of the disease. Age, lifestyle, and environmental factors interact with complex genetic traits to contribute to the etiology. However, approximately 5-10 % of patients with colorectal cancer (CRC) and more than 40 % of patients meeting specific clinical features of the hereditary polyposis syndromes have a discoverable, actionable genetic cause which will significantly alter their medical management. SN - 1534-312X UR - https://www.unboundmedicine.com/medline/citation/26292665/Using_Genetics_to_Identify_Hereditary_Colorectal_Polyposis_and_Cancer_Syndromes_in_Your_Patient_ L2 - https://dx.doi.org/10.1007/s11894-015-0463-z DB - PRIME DP - Unbound Medicine ER -