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Cognition in individuals at risk for Parkinson's: Parkinson associated risk syndrome (PARS) study findings.
Mov Disord. 2016 Jan; 31(1):86-94.MD

Abstract

OBJECTIVES

The Parkinson Associated Risk Syndrome Study identified a cohort of healthy adults with hyposmia and dopamine transporter binding reduction to characterize individuals at risk for Parkinson's disease (PD). We describe the cognitive profile of this cohort.

METHODS

Individuals older than 50 y without PD were recruited. Two hundred twenty-five completed cognitive testing and were included in the final analysis. A neuropsychological test battery was administered and normative scores created for global cognition, memory, executive function/working memory, processing speed/attention, visuospatial abilities, and language domains. Other non-motor symptoms (constipation, depression, anxiety, and rapid eye movement sleep behavior disorder) were assessed through questionnaires.

RESULTS

Individuals with both hyposmia and reduced dopamine transporter binding (n = 38) had lower mean scores for global cognition, executive function/working memory, and memory compared with all other participants (n = 187). In separate multivariate logistic regression models, lower global cognition (odds ratio, 1.97, P = 0.004), and specifically executive function/working memory (odds ratio, 1.84, P = 0.004) scores were associated with membership in the hyposmia with dopamine transporter reduction group. Combining hyposmia with relative impairment on specific cognitive domains increased the odds of dopamine transporter binding reduction compared with hyposmia alone, with the greatest increase in odds for hyposmia plus executive function/working memory relative impairment (68% increase in odds from 4.14 to 6.96).

CONCLUSION

Changes in global cognitive abilities, and specifically executive function/working memory, are present in individuals at risk for PD. Combining non-motor features, including cognition, improves prediction of dopamine transporter binding reduction.

Authors+Show Affiliations

Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. Department of Psychiatry, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA. PD Research, Education and Clinical Center, Philadelphia Veterans Affairs Medical Center, Philadelphia, Pennsylvania, USA.Department of Psychiatry, Yale University School of Medicine, New Haven, Connecticut, USA.Avid Radiopharmaceuticals, Philadelphia, Pennsylvania, USA.Department of Biostatistics, University of Rochester School of Medicine, Rochester, New York, USA.Department of Biostatistics, University of Rochester School of Medicine, Rochester, New York, USA.The Institute for Neurodegenerative Disorders, New Haven, Connecticut, USA.Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.The Institute for Neurodegenerative Disorders, New Haven, Connecticut, USA.The Institute for Neurodegenerative Disorders, New Haven, Connecticut, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

26293177

Citation

Chahine, Lama M., et al. "Cognition in Individuals at Risk for Parkinson's: Parkinson Associated Risk Syndrome (PARS) Study Findings." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 31, no. 1, 2016, pp. 86-94.
Chahine LM, Weintraub D, Hawkins KA, et al. Cognition in individuals at risk for Parkinson's: Parkinson associated risk syndrome (PARS) study findings. Mov Disord. 2016;31(1):86-94.
Chahine, L. M., Weintraub, D., Hawkins, K. A., Siderowf, A., Eberly, S., Oakes, D., Seibyl, J., Stern, M. B., Marek, K., & Jennings, D. (2016). Cognition in individuals at risk for Parkinson's: Parkinson associated risk syndrome (PARS) study findings. Movement Disorders : Official Journal of the Movement Disorder Society, 31(1), 86-94. https://doi.org/10.1002/mds.26373
Chahine LM, et al. Cognition in Individuals at Risk for Parkinson's: Parkinson Associated Risk Syndrome (PARS) Study Findings. Mov Disord. 2016;31(1):86-94. PubMed PMID: 26293177.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cognition in individuals at risk for Parkinson's: Parkinson associated risk syndrome (PARS) study findings. AU - Chahine,Lama M, AU - Weintraub,Daniel, AU - Hawkins,Keith A, AU - Siderowf,Andrew, AU - Eberly,Shirley, AU - Oakes,David, AU - Seibyl,John, AU - Stern,Matthew B, AU - Marek,Kenneth, AU - Jennings,Danna, AU - ,, Y1 - 2015/08/21/ PY - 2015/03/19/received PY - 2015/07/16/revised PY - 2015/07/19/accepted PY - 2015/8/22/entrez PY - 2015/8/22/pubmed PY - 2016/10/22/medline KW - Parkinson's KW - cognition KW - dopaminergic deficit KW - hyposmia KW - prodromal SP - 86 EP - 94 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 31 IS - 1 N2 - OBJECTIVES: The Parkinson Associated Risk Syndrome Study identified a cohort of healthy adults with hyposmia and dopamine transporter binding reduction to characterize individuals at risk for Parkinson's disease (PD). We describe the cognitive profile of this cohort. METHODS: Individuals older than 50 y without PD were recruited. Two hundred twenty-five completed cognitive testing and were included in the final analysis. A neuropsychological test battery was administered and normative scores created for global cognition, memory, executive function/working memory, processing speed/attention, visuospatial abilities, and language domains. Other non-motor symptoms (constipation, depression, anxiety, and rapid eye movement sleep behavior disorder) were assessed through questionnaires. RESULTS: Individuals with both hyposmia and reduced dopamine transporter binding (n = 38) had lower mean scores for global cognition, executive function/working memory, and memory compared with all other participants (n = 187). In separate multivariate logistic regression models, lower global cognition (odds ratio, 1.97, P = 0.004), and specifically executive function/working memory (odds ratio, 1.84, P = 0.004) scores were associated with membership in the hyposmia with dopamine transporter reduction group. Combining hyposmia with relative impairment on specific cognitive domains increased the odds of dopamine transporter binding reduction compared with hyposmia alone, with the greatest increase in odds for hyposmia plus executive function/working memory relative impairment (68% increase in odds from 4.14 to 6.96). CONCLUSION: Changes in global cognitive abilities, and specifically executive function/working memory, are present in individuals at risk for PD. Combining non-motor features, including cognition, improves prediction of dopamine transporter binding reduction. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/26293177/Cognition_in_individuals_at_risk_for_Parkinson's:_Parkinson_associated_risk_syndrome__PARS__study_findings_ DB - PRIME DP - Unbound Medicine ER -