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Maternal nutrition during pregnancy and risk of asthma, wheeze, and atopic diseases during childhood: a systematic review and meta-analysis.
Allergy. 2015 Dec; 70(12):1588-604.A

Abstract

BACKGROUND

Epidemiologic studies suggest a relationship between maternal nutrition during pregnancy and the occurrence of asthma and atopic conditions during childhood. However, individual study results are conflicting. The objective of this meta-analysis was to critically examine the current evidence for an association between nutrition (dietary patterns, food groups, vitamins, or oligo-elements) ingestion during pregnancy and asthma, wheeze, or atopic conditions in childhood.

METHODS

The inclusion criteria were as follows: (i) systematic recording of diet during the gestational period and (ii) documentation of asthma, wheezing, eczema, or other atopic disease in the offspring. The primary outcomes were prevalence of asthma or wheeze among the offspring during childhood; and secondary outcomes were prevalence of eczema, allergic rhinitis, or other atopic conditions.

RESULTS

We found 120 titles, abstracts, and citations, and 32 studies (29 cohorts) were included in this analysis. Data on vitamins, oligo-elements, food groups, and dietary patterns during pregnancy were collected. A meta-analysis revealed that higher maternal intake of vitamin D [odds ratio (OR) = 0.58, 95% confidence interval (CI) = 0.38-0.88], vitamin E (OR = 0.6, 95% CI = 0.46-0.78), and zinc (OR = 0.62, 95% CI = 0.40-0.97) was associated with lower odds of wheeze during childhood. However, none of these or other nutrients was consistently associated with asthma per se or other atopic conditions.

CONCLUSIONS

Current evidence suggests a protective effect of maternal intake of each of three vitamins or nutrients (vitamin D, vitamin E, and zinc) against childhood wheeze but is inconclusive for an effect on asthma or other atopic conditions.

Authors+Show Affiliations

Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.Respiratory and Allergy Units, Arrixaca University Children's Hospital, University of Murcia, Murcia, Spain. IMIB Bio-research Institute, Murcia, Spain.Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA.Respiratory and Allergy Units, Arrixaca University Children's Hospital, University of Murcia, Murcia, Spain. IMIB Bio-research Institute, Murcia, Spain.Division of Pediatric Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA.Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

26296633

Citation

Beckhaus, A A., et al. "Maternal Nutrition During Pregnancy and Risk of Asthma, Wheeze, and Atopic Diseases During Childhood: a Systematic Review and Meta-analysis." Allergy, vol. 70, no. 12, 2015, pp. 1588-604.
Beckhaus AA, Garcia-Marcos L, Forno E, et al. Maternal nutrition during pregnancy and risk of asthma, wheeze, and atopic diseases during childhood: a systematic review and meta-analysis. Allergy. 2015;70(12):1588-604.
Beckhaus, A. A., Garcia-Marcos, L., Forno, E., Pacheco-Gonzalez, R. M., Celedón, J. C., & Castro-Rodriguez, J. A. (2015). Maternal nutrition during pregnancy and risk of asthma, wheeze, and atopic diseases during childhood: a systematic review and meta-analysis. Allergy, 70(12), 1588-604. https://doi.org/10.1111/all.12729
Beckhaus AA, et al. Maternal Nutrition During Pregnancy and Risk of Asthma, Wheeze, and Atopic Diseases During Childhood: a Systematic Review and Meta-analysis. Allergy. 2015;70(12):1588-604. PubMed PMID: 26296633.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal nutrition during pregnancy and risk of asthma, wheeze, and atopic diseases during childhood: a systematic review and meta-analysis. AU - Beckhaus,A A, AU - Garcia-Marcos,L, AU - Forno,E, AU - Pacheco-Gonzalez,R M, AU - Celedón,J C, AU - Castro-Rodriguez,J A, Y1 - 2015/09/21/ PY - 2015/08/17/accepted PY - 2015/8/23/entrez PY - 2015/8/25/pubmed PY - 2016/11/10/medline KW - asthma KW - atopy KW - children KW - diet KW - nutrition KW - pregnancy KW - wheeze SP - 1588 EP - 604 JF - Allergy JO - Allergy VL - 70 IS - 12 N2 - BACKGROUND: Epidemiologic studies suggest a relationship between maternal nutrition during pregnancy and the occurrence of asthma and atopic conditions during childhood. However, individual study results are conflicting. The objective of this meta-analysis was to critically examine the current evidence for an association between nutrition (dietary patterns, food groups, vitamins, or oligo-elements) ingestion during pregnancy and asthma, wheeze, or atopic conditions in childhood. METHODS: The inclusion criteria were as follows: (i) systematic recording of diet during the gestational period and (ii) documentation of asthma, wheezing, eczema, or other atopic disease in the offspring. The primary outcomes were prevalence of asthma or wheeze among the offspring during childhood; and secondary outcomes were prevalence of eczema, allergic rhinitis, or other atopic conditions. RESULTS: We found 120 titles, abstracts, and citations, and 32 studies (29 cohorts) were included in this analysis. Data on vitamins, oligo-elements, food groups, and dietary patterns during pregnancy were collected. A meta-analysis revealed that higher maternal intake of vitamin D [odds ratio (OR) = 0.58, 95% confidence interval (CI) = 0.38-0.88], vitamin E (OR = 0.6, 95% CI = 0.46-0.78), and zinc (OR = 0.62, 95% CI = 0.40-0.97) was associated with lower odds of wheeze during childhood. However, none of these or other nutrients was consistently associated with asthma per se or other atopic conditions. CONCLUSIONS: Current evidence suggests a protective effect of maternal intake of each of three vitamins or nutrients (vitamin D, vitamin E, and zinc) against childhood wheeze but is inconclusive for an effect on asthma or other atopic conditions. SN - 1398-9995 UR - https://www.unboundmedicine.com/medline/citation/26296633/Maternal_nutrition_during_pregnancy_and_risk_of_asthma_wheeze_and_atopic_diseases_during_childhood:_a_systematic_review_and_meta_analysis_ L2 - https://doi.org/10.1111/all.12729 DB - PRIME DP - Unbound Medicine ER -