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Modulation of endoplasmic reticulum stress in Parkinson's disease.
Eur J Pharmacol. 2015 Oct 15; 765:154-6.EJ

Abstract

Parkinson's disease is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra in the midbrain. However, the etiology of the reduction in dopaminergic neurons remains unclear. Recently, it has been suggested that oxidative stress, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction are involved in neuronal cell death in the pathology of Parkinson's disease. Furthermore, it has been suggested that some existing anti- Parkinson's disease drugs have protective effects against cell death. Among these, zonisamide exerts neuroprotective effects partly by modulating ER stress. Elucidating the involvement of ER stress in in vitro and in vivo Parkinson's disease models and investigating the mechanisms against ER stress will contribute to the search for new therapeutic agents for Parkinson's disease.

Authors+Show Affiliations

Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan.Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan.Department of Biofunctional Evaluation, Molecular Pharmacology, Gifu Pharmaceutical University, 1-25-4 Daigaku-nishi, Gifu, 501-1196, Japan. Electronic address: hidehara@gifu-pu.ac.jp.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26297973

Citation

Tsujii, Saori, et al. "Modulation of Endoplasmic Reticulum Stress in Parkinson's Disease." European Journal of Pharmacology, vol. 765, 2015, pp. 154-6.
Tsujii S, Ishisaka M, Hara H. Modulation of endoplasmic reticulum stress in Parkinson's disease. Eur J Pharmacol. 2015;765:154-6.
Tsujii, S., Ishisaka, M., & Hara, H. (2015). Modulation of endoplasmic reticulum stress in Parkinson's disease. European Journal of Pharmacology, 765, 154-6. https://doi.org/10.1016/j.ejphar.2015.08.033
Tsujii S, Ishisaka M, Hara H. Modulation of Endoplasmic Reticulum Stress in Parkinson's Disease. Eur J Pharmacol. 2015 Oct 15;765:154-6. PubMed PMID: 26297973.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of endoplasmic reticulum stress in Parkinson's disease. AU - Tsujii,Saori, AU - Ishisaka,Mitsue, AU - Hara,Hideaki, Y1 - 2015/08/20/ PY - 2015/03/19/received PY - 2015/08/17/revised PY - 2015/08/18/accepted PY - 2015/8/23/entrez PY - 2015/8/25/pubmed PY - 2016/8/2/medline KW - 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (PubChem CID: 1388) KW - 1-methyl-4-phenylpyridinium (PubChem CID: 6918492) KW - Endoplasmic reticulum stress KW - Parkinson's disease KW - Zonisamide KW - zonisamide (PubChem CID: 5734) SP - 154 EP - 6 JF - European journal of pharmacology JO - Eur J Pharmacol VL - 765 N2 - Parkinson's disease is a neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra in the midbrain. However, the etiology of the reduction in dopaminergic neurons remains unclear. Recently, it has been suggested that oxidative stress, endoplasmic reticulum (ER) stress, and mitochondrial dysfunction are involved in neuronal cell death in the pathology of Parkinson's disease. Furthermore, it has been suggested that some existing anti- Parkinson's disease drugs have protective effects against cell death. Among these, zonisamide exerts neuroprotective effects partly by modulating ER stress. Elucidating the involvement of ER stress in in vitro and in vivo Parkinson's disease models and investigating the mechanisms against ER stress will contribute to the search for new therapeutic agents for Parkinson's disease. SN - 1879-0712 UR - https://www.unboundmedicine.com/medline/citation/26297973/Modulation_of_endoplasmic_reticulum_stress_in_Parkinson's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-2999(15)30207-7 DB - PRIME DP - Unbound Medicine ER -