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Mean centering of double divisor ratio spectra, a novel spectrophotometric method for analysis of ternary mixtures.
Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 15; 153:132-42.SA

Abstract

A novel spectrophotometric method was developed for determination of ternary mixtures without previous separation, showing significant advantages over conventional methods. The new method is based on mean centering of double divisor ratio spectra. The mathematical explanation of the procedure is illustrated. The method was evaluated by determination of model ternary mixture and by the determination of Amlodipine (AML), Aliskiren (ALI) and Hydrochlorothiazide (HCT) in laboratory prepared mixtures and in a commercial pharmaceutical preparation. For proper presentation of the advantages and applicability of the new method, a comparative study was established between the new mean centering of double divisor ratio spectra (MCDD) and two similar methods used for analysis of ternary mixtures, namely mean centering (MC) and double divisor of ratio spectra-derivative spectrophotometry (DDRS-DS). The method was also compared with a reported one for analysis of the pharmaceutical preparation. The method was validated according to the ICH guidelines and accuracy, precision, repeatability and robustness were found to be within the acceptable limits.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Hassan SA
Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt. Electronic address: said.hassan@pharma.cu.edu.eg.
Elzanfaly ES
Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt.
Salem MY
Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt.
El-Zeany BA
Department of Analytical Chemistry, Faculty of Pharmacy, Cairo University, Kasr El-Aini Street, 11562 Cairo, Egypt.

MeSH

AmidesAmlodipineAnalysis of VarianceChromatography, High Pressure LiquidFumaratesHydrochlorothiazideMethanolModels, MolecularReference StandardsReproducibility of ResultsSpectrophotometryTablets

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26298680

Citation

Hassan, Said A., et al. "Mean Centering of Double Divisor Ratio Spectra, a Novel Spectrophotometric Method for Analysis of Ternary Mixtures." Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, vol. 153, 2016, pp. 132-42.
Hassan SA, Elzanfaly ES, Salem MY, et al. Mean centering of double divisor ratio spectra, a novel spectrophotometric method for analysis of ternary mixtures. Spectrochim Acta A Mol Biomol Spectrosc. 2016;153:132-42.
Hassan, S. A., Elzanfaly, E. S., Salem, M. Y., & El-Zeany, B. A. (2016). Mean centering of double divisor ratio spectra, a novel spectrophotometric method for analysis of ternary mixtures. Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy, 153, 132-42. https://doi.org/10.1016/j.saa.2015.07.109
Hassan SA, et al. Mean Centering of Double Divisor Ratio Spectra, a Novel Spectrophotometric Method for Analysis of Ternary Mixtures. Spectrochim Acta A Mol Biomol Spectrosc. 2016 Jan 15;153:132-42. PubMed PMID: 26298680.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mean centering of double divisor ratio spectra, a novel spectrophotometric method for analysis of ternary mixtures. AU - Hassan,Said A, AU - Elzanfaly,Eman S, AU - Salem,Maissa Y, AU - El-Zeany,Badr A, Y1 - 2015/08/10/ PY - 2015/06/06/received PY - 2015/07/29/revised PY - 2015/07/30/accepted PY - 2015/8/24/entrez PY - 2015/8/25/pubmed PY - 2016/9/22/medline KW - Aliskiren KW - Amlodipine KW - Derivative spectrophotometry KW - Double divisor ratio spectra KW - Hydrochlorothiazide KW - Mean centering SP - 132 EP - 42 JF - Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy JO - Spectrochim Acta A Mol Biomol Spectrosc VL - 153 N2 - A novel spectrophotometric method was developed for determination of ternary mixtures without previous separation, showing significant advantages over conventional methods. The new method is based on mean centering of double divisor ratio spectra. The mathematical explanation of the procedure is illustrated. The method was evaluated by determination of model ternary mixture and by the determination of Amlodipine (AML), Aliskiren (ALI) and Hydrochlorothiazide (HCT) in laboratory prepared mixtures and in a commercial pharmaceutical preparation. For proper presentation of the advantages and applicability of the new method, a comparative study was established between the new mean centering of double divisor ratio spectra (MCDD) and two similar methods used for analysis of ternary mixtures, namely mean centering (MC) and double divisor of ratio spectra-derivative spectrophotometry (DDRS-DS). The method was also compared with a reported one for analysis of the pharmaceutical preparation. The method was validated according to the ICH guidelines and accuracy, precision, repeatability and robustness were found to be within the acceptable limits. SN - 1873-3557 UR - https://www.unboundmedicine.com/medline/citation/26298680/Mean_centering_of_double_divisor_ratio_spectra_a_novel_spectrophotometric_method_for_analysis_of_ternary_mixtures_ DB - PRIME DP - Unbound Medicine ER -