Tags

Type your tag names separated by a space and hit enter

A prospective study of Willis-Ekbom disease/restless legs syndrome during and after pregnancy.
Sleep Med 2015; 16(9):1036-40SM

Abstract

OBJECTIVES

Willis-Ekbom disease/restless legs syndrome (WED/RLS) is the most common sleep-related movement disorder in pregnancy. We designed a prospective longitudinal study to investigate the correlates of WED/RLS during and after pregnancy.

DESIGN

A total of 138 pregnant women with WED/RLS and a control group of 251 age-matched pregnant women were enrolled prospectively. A questionnaire was administered during a face-to-face interview at first evaluation during pregnancy and three months after delivery.

RESULTS

Among all women in the first trimester, 15.6% were diagnosed with WED/RLS, whereas 32.8% of those in the second trimester and 38.8% of those in the third trimester were diagnosed with WED/RLS (p = 0.032). In regression analysis, later gestational age [p < 0.001; odds ratio (OR) 1.054] and previous history of WED/RLS (p = 0.001; OR 2.795) were positively correlated with the presence of WED/RLS, while ferritin levels (p = 0.001; OR 0.956) were negatively correlated with the presence of WED/RLS. Ferritin levels were also negatively correlated with the International RLS Study Group severity index (p = 0.041). Forty-eight patients (34.8%) experienced WED/RLS symptomatology after delivery. The ferritin levels were lower, and the mean number of pregnancies was higher, in women with residual WED/RLS (p = 0.008).

CONCLUSION

Our survey showed that WED/RLS was more common in the second and third trimesters. Emergence of WED/RLS during the second trimester was strongly associated with residual WED/RLS. Lower ferritin levels were associated with both WED/RLS in pregnancy and residual WED/RLS after delivery. A higher number of pregnancies were also associated with a greater likelihood of having residual WED/RLS after delivery.

Authors+Show Affiliations

Neurology Clinic, Gaziantep Dr Ersin Arslan State Hospital, Gaziantep, Turkey.Department of Neurology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey. Electronic address: drgulcinbenbir@yahoo.com.Neurology Clinic, Gaziantep Dr Ersin Arslan State Hospital, Gaziantep, Turkey.Department of Neurology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.Department of Obstetrics and Gynecology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.Department of Obstetrics and Gynecology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.Department of Neurology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.Neurology Clinic, Gaziantep Dr Ersin Arslan State Hospital, Gaziantep, Turkey.Department of Neurology, Istanbul University Cerrahpasa Faculty of Medicine, Istanbul, Turkey.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26298776

Citation

Neyal, Abdurrahman, et al. "A Prospective Study of Willis-Ekbom Disease/restless Legs Syndrome During and After Pregnancy." Sleep Medicine, vol. 16, no. 9, 2015, pp. 1036-40.
Neyal A, Senel GB, Aslan R, et al. A prospective study of Willis-Ekbom disease/restless legs syndrome during and after pregnancy. Sleep Med. 2015;16(9):1036-40.
Neyal, A., Senel, G. B., Aslan, R., Nalbantoglu, M., Acikgoz, S., Yilmaz, N., ... Karadeniz, D. (2015). A prospective study of Willis-Ekbom disease/restless legs syndrome during and after pregnancy. Sleep Medicine, 16(9), pp. 1036-40. doi:10.1016/j.sleep.2015.01.026.
Neyal A, et al. A Prospective Study of Willis-Ekbom Disease/restless Legs Syndrome During and After Pregnancy. Sleep Med. 2015;16(9):1036-40. PubMed PMID: 26298776.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of Willis-Ekbom disease/restless legs syndrome during and after pregnancy. AU - Neyal,Abdurrahman, AU - Senel,Gulcin Benbir, AU - Aslan,Rahime, AU - Nalbantoglu,Mecbure, AU - Acikgoz,Serdar, AU - Yilmaz,Nevin, AU - Tumay,Feray Bolukbasi, AU - Neyal,Munife, AU - Karadeniz,Derya, Y1 - 2015/05/28/ PY - 2014/10/15/received PY - 2015/01/22/revised PY - 2015/01/24/accepted PY - 2015/8/24/entrez PY - 2015/8/25/pubmed PY - 2016/6/16/medline KW - Delivery KW - Ferritin levels KW - Pregnancy KW - Willis–Ekbom disease SP - 1036 EP - 40 JF - Sleep medicine JO - Sleep Med. VL - 16 IS - 9 N2 - OBJECTIVES: Willis-Ekbom disease/restless legs syndrome (WED/RLS) is the most common sleep-related movement disorder in pregnancy. We designed a prospective longitudinal study to investigate the correlates of WED/RLS during and after pregnancy. DESIGN: A total of 138 pregnant women with WED/RLS and a control group of 251 age-matched pregnant women were enrolled prospectively. A questionnaire was administered during a face-to-face interview at first evaluation during pregnancy and three months after delivery. RESULTS: Among all women in the first trimester, 15.6% were diagnosed with WED/RLS, whereas 32.8% of those in the second trimester and 38.8% of those in the third trimester were diagnosed with WED/RLS (p = 0.032). In regression analysis, later gestational age [p < 0.001; odds ratio (OR) 1.054] and previous history of WED/RLS (p = 0.001; OR 2.795) were positively correlated with the presence of WED/RLS, while ferritin levels (p = 0.001; OR 0.956) were negatively correlated with the presence of WED/RLS. Ferritin levels were also negatively correlated with the International RLS Study Group severity index (p = 0.041). Forty-eight patients (34.8%) experienced WED/RLS symptomatology after delivery. The ferritin levels were lower, and the mean number of pregnancies was higher, in women with residual WED/RLS (p = 0.008). CONCLUSION: Our survey showed that WED/RLS was more common in the second and third trimesters. Emergence of WED/RLS during the second trimester was strongly associated with residual WED/RLS. Lower ferritin levels were associated with both WED/RLS in pregnancy and residual WED/RLS after delivery. A higher number of pregnancies were also associated with a greater likelihood of having residual WED/RLS after delivery. SN - 1878-5506 UR - https://www.unboundmedicine.com/medline/citation/26298776/A_prospective_study_of_Willis_Ekbom_disease/restless_legs_syndrome_during_and_after_pregnancy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1389-9457(15)00737-6 DB - PRIME DP - Unbound Medicine ER -