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Temporal-spatial pathological changes in the brains of permissive and non-permissive hosts experimentally infected with Angiostrongylus cantonensis.
Exp Parasitol. 2015 Oct; 157:177-84.EP

Abstract

Human cerebral angiostrongyliasis becomes an emerging disease in many parts of the world. By postmortem examination, Angiostrongylus cantonensis have been reported to cause severe pathological changes in the central nervous system. The present study was designed to determine the temporal-spatial pathological changes through experimental infections and histopathological examination of permissive (SD rats) and non-permissive (ICR mice) hosts. After infecting SD rats with 25, 50, or 100 third-stage larvae (L3) and ICR mice with 25 L3, one animal from each group was sacrificed daily from day 1 to day 30 post-infection. Each rat brain was cut into six sections and mouse brain into five sections. These sections were stained with haematoxylin and eosin and examined microscopically. Eosinophilic meningitis was found to be the most commonly pathological change and occurred on day 17 post-infection in rats with 25 L3, day 9 in the 50- or 100-L3 groups, and day 12 in infected mice. Thickness of the meninges increased 9-24 folds in infected rats and 89 folds in an infected mouse on day 28. Encephalitis, congestion, perivascular cuffing, and haemorrhage were revealed in infected mice and rats with 100 L3. Fifth-stage larvae were frequently observed in the meninges but occasionally in the parenchyma. Significant correlations between meningitis and presence of larvae in the meninges were found in the three infected rat groups but not in the infected mice. The results indicate that the clinical course of A. cantonensis infection is not self-limited but becomes more severe with the intensity of infection.

Authors+Show Affiliations

Department of Parasitology, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan; Molecular Infectious Disease Research Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan. Electronic address: wanglc@mail.cgu.edu.tw.Department of Pathology, Chang-Gung Memorial Hospital, Chang-Gung Children Hospital at Linkou and Chang-Gung University, Taoyuan 333, Taiwan.Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.Department of Parasitology, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.Department of Parasitology, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26299243

Citation

Wang, Lian-Chen, et al. "Temporal-spatial Pathological Changes in the Brains of Permissive and Non-permissive Hosts Experimentally Infected With Angiostrongylus Cantonensis." Experimental Parasitology, vol. 157, 2015, pp. 177-84.
Wang LC, Jung SM, Chen KY, et al. Temporal-spatial pathological changes in the brains of permissive and non-permissive hosts experimentally infected with Angiostrongylus cantonensis. Exp Parasitol. 2015;157:177-84.
Wang, L. C., Jung, S. M., Chen, K. Y., Wang, T. Y., & Li, C. H. (2015). Temporal-spatial pathological changes in the brains of permissive and non-permissive hosts experimentally infected with Angiostrongylus cantonensis. Experimental Parasitology, 157, 177-84. https://doi.org/10.1016/j.exppara.2015.08.006
Wang LC, et al. Temporal-spatial Pathological Changes in the Brains of Permissive and Non-permissive Hosts Experimentally Infected With Angiostrongylus Cantonensis. Exp Parasitol. 2015;157:177-84. PubMed PMID: 26299243.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Temporal-spatial pathological changes in the brains of permissive and non-permissive hosts experimentally infected with Angiostrongylus cantonensis. AU - Wang,Lian-Chen, AU - Jung,Shih-Ming, AU - Chen,Kuang-Yao, AU - Wang,Tzu-Yi, AU - Li,Chung-Han, Y1 - 2015/08/20/ PY - 2014/12/17/received PY - 2015/07/17/revised PY - 2015/08/16/accepted PY - 2015/8/25/entrez PY - 2015/8/25/pubmed PY - 2016/4/30/medline KW - Angiostrongylus cantonensis KW - Brain KW - Non-permissive hosts KW - Pathological changes KW - Permissive hosts SP - 177 EP - 84 JF - Experimental parasitology JO - Exp Parasitol VL - 157 N2 - Human cerebral angiostrongyliasis becomes an emerging disease in many parts of the world. By postmortem examination, Angiostrongylus cantonensis have been reported to cause severe pathological changes in the central nervous system. The present study was designed to determine the temporal-spatial pathological changes through experimental infections and histopathological examination of permissive (SD rats) and non-permissive (ICR mice) hosts. After infecting SD rats with 25, 50, or 100 third-stage larvae (L3) and ICR mice with 25 L3, one animal from each group was sacrificed daily from day 1 to day 30 post-infection. Each rat brain was cut into six sections and mouse brain into five sections. These sections were stained with haematoxylin and eosin and examined microscopically. Eosinophilic meningitis was found to be the most commonly pathological change and occurred on day 17 post-infection in rats with 25 L3, day 9 in the 50- or 100-L3 groups, and day 12 in infected mice. Thickness of the meninges increased 9-24 folds in infected rats and 89 folds in an infected mouse on day 28. Encephalitis, congestion, perivascular cuffing, and haemorrhage were revealed in infected mice and rats with 100 L3. Fifth-stage larvae were frequently observed in the meninges but occasionally in the parenchyma. Significant correlations between meningitis and presence of larvae in the meninges were found in the three infected rat groups but not in the infected mice. The results indicate that the clinical course of A. cantonensis infection is not self-limited but becomes more severe with the intensity of infection. SN - 1090-2449 UR - https://www.unboundmedicine.com/medline/citation/26299243/Temporal_spatial_pathological_changes_in_the_brains_of_permissive_and_non_permissive_hosts_experimentally_infected_with_Angiostrongylus_cantonensis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0014-4894(15)30022-9 DB - PRIME DP - Unbound Medicine ER -