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Polymorphism - 116C/G of the human X box binding protein 1 gene is associated with risk of type 2 diabetes in a Chinese Han population.
Gene 2016; 575(1):71-4GENE

Abstract

Evidence has been obtained showing that endoplasmic reticulum (ER) stress is closely associated with the development of type 2 diabetes (T2D) and that the human X box binding protein 1 (XBP1) is an important transcription factor involved in the development of ER stress. The study aimed to analyze the potential association between polymorphism -116C/G of XBP1 and the risk of T2D. The association between XBP1 polymorphism -116C/G and T2D risk was assessed among 1058 consecutive unrelated subjects, including 523 T2D patients and 535 healthy controls, in a case control study. The -116GG genotype and -116G allele were more frequent in T2D subjects compared with control subjects by statistical analysis, showing that the -116GG homozygote polymorphism of XBP1 might lead to increased susceptibility to T2D in a Chinese Han population. T2D subjects with the -116GG genotype had higher fasting plasma glucose levels, fasting insulin levels, and HbA1c and worse HOMA-IR than the T2D subjects with -116CG and -116CC genotypes (P<0.0001). The study supports a role for -116C/G polymorphism of the XBP1 promoter in the pathogenesis of T2D in a Chinese Han population, and more studies are needed to further evaluate our results.

Authors+Show Affiliations

Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China; Department of Chronic Disease, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China.Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China.Department of Epidemiology and Statistics, College of Public Health, Jiamusi University, Jiamusi 154007, China.Department of Chronic Disease, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China.Department of Chronic Disease, Shenzhen Nanshan Center for Chronic Disease Control, Shenzhen 518054, China.Institute of Neurology, Guangdong Medical College, Zhanjiang 524001, China. Electronic address: zhaobine@163.net.Guangdong Key Laboratory of Age-Related Cardiac and Cerebral Diseases, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China. Electronic address: likeshen1971@126.com.

Pub Type(s)

Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26299655

Citation

Liu, Shengyuan, et al. "Polymorphism - 116C/G of the Human X Box Binding Protein 1 Gene Is Associated With Risk of Type 2 Diabetes in a Chinese Han Population." Gene, vol. 575, no. 1, 2016, pp. 71-4.
Liu S, Ma G, Yao S, et al. Polymorphism - 116C/G of the human X box binding protein 1 gene is associated with risk of type 2 diabetes in a Chinese Han population. Gene. 2016;575(1):71-4.
Liu, S., Ma, G., Yao, S., Chen, Z., Wang, C., Zhao, B., & Li, K. (2016). Polymorphism - 116C/G of the human X box binding protein 1 gene is associated with risk of type 2 diabetes in a Chinese Han population. Gene, 575(1), pp. 71-4. doi:10.1016/j.gene.2015.08.037.
Liu S, et al. Polymorphism - 116C/G of the Human X Box Binding Protein 1 Gene Is Associated With Risk of Type 2 Diabetes in a Chinese Han Population. Gene. 2016 Jan 1;575(1):71-4. PubMed PMID: 26299655.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polymorphism - 116C/G of the human X box binding protein 1 gene is associated with risk of type 2 diabetes in a Chinese Han population. AU - Liu,Shengyuan, AU - Ma,Guoda, AU - Yao,Songpo, AU - Chen,Zhongwei, AU - Wang,Changyi, AU - Zhao,Bin, AU - Li,Keshen, Y1 - 2015/08/21/ PY - 2015/03/09/received PY - 2015/07/24/revised PY - 2015/08/19/accepted PY - 2015/8/25/entrez PY - 2015/8/25/pubmed PY - 2016/2/26/medline KW - ER stress response KW - Genotype KW - Polymorphism KW - Type 2 diabetes KW - XBP1 SP - 71 EP - 4 JF - Gene JO - Gene VL - 575 IS - 1 N2 - Evidence has been obtained showing that endoplasmic reticulum (ER) stress is closely associated with the development of type 2 diabetes (T2D) and that the human X box binding protein 1 (XBP1) is an important transcription factor involved in the development of ER stress. The study aimed to analyze the potential association between polymorphism -116C/G of XBP1 and the risk of T2D. The association between XBP1 polymorphism -116C/G and T2D risk was assessed among 1058 consecutive unrelated subjects, including 523 T2D patients and 535 healthy controls, in a case control study. The -116GG genotype and -116G allele were more frequent in T2D subjects compared with control subjects by statistical analysis, showing that the -116GG homozygote polymorphism of XBP1 might lead to increased susceptibility to T2D in a Chinese Han population. T2D subjects with the -116GG genotype had higher fasting plasma glucose levels, fasting insulin levels, and HbA1c and worse HOMA-IR than the T2D subjects with -116CG and -116CC genotypes (P<0.0001). The study supports a role for -116C/G polymorphism of the XBP1 promoter in the pathogenesis of T2D in a Chinese Han population, and more studies are needed to further evaluate our results. SN - 1879-0038 UR - https://www.unboundmedicine.com/medline/citation/26299655/Polymorphism___116C/G_of_the_human_X_box_binding_protein_1_gene_is_associated_with_risk_of_type_2_diabetes_in_a_Chinese_Han_population_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1119(15)01006-9 DB - PRIME DP - Unbound Medicine ER -