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Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study.
J Trace Elem Med Biol 2015; 32:66-72JT

Abstract

BACKGROUND

Chromium is an essential mineral that contributes to normal glucose function and lipid metabolism. This study evaluated the effect of chromium picolinate (CrPic) supplementation in patients with type 2 diabetes mellitus (T2DM).

METHODS

A four month controlled, single blind, randomized trial was performed with 71 patients with poorly controlled (hemoglobin A1c [HbA1c]>7%) T2DM divided into 2 groups: Control (n=39, using placebo), and supplemented (n=32, using 600μg/day CrPic). All patients received nutritional guidance according to the American Diabetes Association (ADA), and kept using prescribed medications. Fasting and postprandial glucose, HbA1c, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides and serum ferritin were evaluated.

RESULTS

CrPic supplementation significantly reduced the fasting glucose concentration (-31.0mg/dL supplemented group; -14.0mg/dL control group; p<0.05, post- vs. pre-treatment, in each group) and postprandial glucose concentration (-37.0mg/dL in the supplemented group; -11.5 mg/dL in the control group; p<0.05). HbA1c values were also significantly reduced in both groups (p<0.001, comparing post- vs. pre-treatment groups). Post-treatment HbA1c values in supplemented patients were significantly lower than those of control patients. HbA1c lowering in the supplemented group (-1.90), and in the control group (-1.00), was also significant, comparing pre- and post-treatment values, for each group (p<0.001 and p<0.05, respectively). CrPic increased serum chromium concentrations (p<0.001), when comparing the supplemented group before and after supplementation. No significant difference in lipid profile was observed in the supplemented group; however, total cholesterol, HDL-c and LDL-c were significantly lowered, comparing pre- and post-treatment period, in the control group (p<0.05).

CONCLUSIONS

CrPic supplementation had a beneficial effect on glycemic control in patients with poorly controlled T2DM, without affecting the lipid profile. Additional studies are necessary to investigate the effect of long-term CrPic supplementation.

Authors+Show Affiliations

Post-Graduate Program in Health Sciences, Federal University of Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias, S/N-Petrópolis, Natal-RN CEP 59012-570, Brazil. Electronic address: ananpaiva@gmail.com.Department of Internal Medicine, Federal University of Rio Grande do Norte (UFRN), Avenida: Nilo Peçanha, 620, Petrópolis, Natal-RN CEP 59012-300, Brazil. Electronic address: josivanlima@gmail.com.Health Sciences College of Trairi, Federal University of Rio Grande do Norte (UFRN) Rua Trairí, S/N-Centro-Santa Cruz/RN, CEP 59200-000, Brazil. Electronic address: annacqm@yahoo.com.br.Graduate Student in the Department of Nutrition, Federal University of Rio Grande do Norte (UFRN), Av. Senador Salgado Filho, 3000 Lagoa Nova, Natal-RN CEP 59078-970, Brazil. Electronic address: figueiredoheverton@gmail.com.Graduate Student in the Department of Nutrition, Federal University of Rio Grande do Norte (UFRN), Av. Senador Salgado Filho, 3000 Lagoa Nova, Natal-RN CEP 59078-970, Brazil. Electronic address: raianalourenco.a@hotmail.com.Post Doctoral Fellow in the Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias, S/N-Petrópolis, Natal-RN CEP 59012-570, Brazil. Electronic address: marcelaururahy@yahoo.com.br.Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias, S/N-Petrópolis, Natal-RN CEP 59012-570, Brazil. Electronic address: adrirezende@yahoo.com.Department of Internal Medicine, Federal University of Rio Grande do Norte (UFRN), Avenida: Nilo Peçanha, 620, Petrópolis, Natal-RN CEP 59012-300, Brazil. Electronic address: brandao-neto@live.com.Department of Clinical and Toxicological Analyses, Federal University of Rio Grande do Norte (UFRN), Rua General Gustavo Cordeiro de Farias, S/N-Petrópolis, Natal-RN CEP 59012-570, Brazil. Electronic address: mgalmeida84@gmail.com.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

26302914

Citation

Paiva, Ana N., et al. "Beneficial Effects of Oral Chromium Picolinate Supplementation On Glycemic Control in Patients With Type 2 Diabetes: a Randomized Clinical Study." Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), vol. 32, 2015, pp. 66-72.
Paiva AN, Lima JG, Medeiros AC, et al. Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study. J Trace Elem Med Biol. 2015;32:66-72.
Paiva, A. N., Lima, J. G., Medeiros, A. C., Figueiredo, H. A., Andrade, R. L., Ururahy, M. A., ... Almeida, M. d. (2015). Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study. Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS), 32, pp. 66-72. doi:10.1016/j.jtemb.2015.05.006.
Paiva AN, et al. Beneficial Effects of Oral Chromium Picolinate Supplementation On Glycemic Control in Patients With Type 2 Diabetes: a Randomized Clinical Study. J Trace Elem Med Biol. 2015;32:66-72. PubMed PMID: 26302914.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Beneficial effects of oral chromium picolinate supplementation on glycemic control in patients with type 2 diabetes: A randomized clinical study. AU - Paiva,Ana N, AU - Lima,Josivan G de, AU - Medeiros,Anna C Q de, AU - Figueiredo,Heverton A O, AU - Andrade,Raiana L de, AU - Ururahy,Marcela A G, AU - Rezende,Adriana A, AU - Brandão-Neto,José, AU - Almeida,Maria das G, Y1 - 2015/05/28/ PY - 2014/11/10/received PY - 2015/05/07/revised PY - 2015/05/26/accepted PY - 2015/8/26/entrez PY - 2015/8/26/pubmed PY - 2016/5/24/medline KW - Chromium picolinate KW - Dietary supplements KW - Dyslipidemia KW - Type 2 diabetes mellitus SP - 66 EP - 72 JF - Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) JO - J Trace Elem Med Biol VL - 32 N2 - BACKGROUND: Chromium is an essential mineral that contributes to normal glucose function and lipid metabolism. This study evaluated the effect of chromium picolinate (CrPic) supplementation in patients with type 2 diabetes mellitus (T2DM). METHODS: A four month controlled, single blind, randomized trial was performed with 71 patients with poorly controlled (hemoglobin A1c [HbA1c]>7%) T2DM divided into 2 groups: Control (n=39, using placebo), and supplemented (n=32, using 600μg/day CrPic). All patients received nutritional guidance according to the American Diabetes Association (ADA), and kept using prescribed medications. Fasting and postprandial glucose, HbA1c, total cholesterol, high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides and serum ferritin were evaluated. RESULTS: CrPic supplementation significantly reduced the fasting glucose concentration (-31.0mg/dL supplemented group; -14.0mg/dL control group; p<0.05, post- vs. pre-treatment, in each group) and postprandial glucose concentration (-37.0mg/dL in the supplemented group; -11.5 mg/dL in the control group; p<0.05). HbA1c values were also significantly reduced in both groups (p<0.001, comparing post- vs. pre-treatment groups). Post-treatment HbA1c values in supplemented patients were significantly lower than those of control patients. HbA1c lowering in the supplemented group (-1.90), and in the control group (-1.00), was also significant, comparing pre- and post-treatment values, for each group (p<0.001 and p<0.05, respectively). CrPic increased serum chromium concentrations (p<0.001), when comparing the supplemented group before and after supplementation. No significant difference in lipid profile was observed in the supplemented group; however, total cholesterol, HDL-c and LDL-c were significantly lowered, comparing pre- and post-treatment period, in the control group (p<0.05). CONCLUSIONS: CrPic supplementation had a beneficial effect on glycemic control in patients with poorly controlled T2DM, without affecting the lipid profile. Additional studies are necessary to investigate the effect of long-term CrPic supplementation. SN - 1878-3252 UR - https://www.unboundmedicine.com/medline/citation/26302914/Beneficial_effects_of_oral_chromium_picolinate_supplementation_on_glycemic_control_in_patients_with_type_2_diabetes:_A_randomized_clinical_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0946-672X(15)30003-1 DB - PRIME DP - Unbound Medicine ER -