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Reproducibility of the bronchoconstrictive response to eucapnic voluntary hyperpnoea.
Respir Med. 2015 Oct; 109(10):1262-7.RM

Abstract

BACKGROUND

Eucapnic voluntary hyperpnoea (EVH) is considered an effective bronchoprovocation challenge for identifying exercise-induced bronchoconstriction (EIB). However, the reproducibility of the hyperpnoea-induced bronchoconstriction (HIB) response elicited by EVH remains unknown and was therefore the focus of this study.

METHODS

Two cohorts of 16 physically active males (each cohort comprised 8 controls and 8 with physician diagnosis of asthma) participated in two studies of the short- and long-term reproducibility of the bronchoconstrictive response to an EVH test with dry air. EVH was performed on days 0, 7, 14, and 21 (short-term study), and 0, 35, and 70 (long-term study). HIB was diagnosed by a ≥10% fall in forced expiratory volume in 1 s (FEV1) after EVH.

RESULTS

On day 0 of the short-term study, FEV1 fell by 2 ± 1% (P < 0.05) and 27 ± 18% (P < 0.01) from pre-to post-EVH in control and HIB-positive groups respectively. The post-EVH fall in FEV1 did not differ across the short-term study test days. In the HIB-positive group, the day-to-day coefficient of variation, reproducibility, and smallest meaningful change for the fall in FEV1 were 12%, 328 mL, and 164 mL, respectively. On day 0 of the long-term study, FEV1 fell by 2 ± 2% and 25 ± 18% (P < 0.01) after EVH in control and HIB-positive groups respectively. The post-EVH fall in FEV1 did not differ across the long-term study test days. In the HIB-positive group, the day-to-day coefficient of variation, reproducibility, and smallest meaningful change for the fall in FEV1 were 10%, 196 mL, and 98 mL respectively.

CONCLUSION

The EVH test elicits a reproducible bronchoconstrictive response in physically active males with physician diagnosed asthma. These data thus support the clinical utility of the EVH test for EIB screening and monitoring.

Authors+Show Affiliations

Sport, Health and Performance Enhancement (SHAPE) Research Group, School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK. Electronic address: Neil.williams@ntu.ac.uk.Sport, Health and Performance Enhancement (SHAPE) Research Group, School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK. Electronic address: Michael.johnson@ntu.ac.uk.Sport, Health and Performance Enhancement (SHAPE) Research Group, School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK. Electronic address: Kirsty.hunter@ntu.ac.uk.Sport, Health and Performance Enhancement (SHAPE) Research Group, School of Science and Technology, Nottingham Trent University, Nottingham, NG11 8NS, UK. Electronic address: Graham.sharpe@ntu.ac.uk.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26303339

Citation

Williams, N C., et al. "Reproducibility of the Bronchoconstrictive Response to Eucapnic Voluntary Hyperpnoea." Respiratory Medicine, vol. 109, no. 10, 2015, pp. 1262-7.
Williams NC, Johnson MA, Hunter KA, et al. Reproducibility of the bronchoconstrictive response to eucapnic voluntary hyperpnoea. Respir Med. 2015;109(10):1262-7.
Williams, N. C., Johnson, M. A., Hunter, K. A., & Sharpe, G. R. (2015). Reproducibility of the bronchoconstrictive response to eucapnic voluntary hyperpnoea. Respiratory Medicine, 109(10), 1262-7. https://doi.org/10.1016/j.rmed.2015.08.006
Williams NC, et al. Reproducibility of the Bronchoconstrictive Response to Eucapnic Voluntary Hyperpnoea. Respir Med. 2015;109(10):1262-7. PubMed PMID: 26303339.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reproducibility of the bronchoconstrictive response to eucapnic voluntary hyperpnoea. AU - Williams,N C, AU - Johnson,M A, AU - Hunter,K A, AU - Sharpe,G R, Y1 - 2015/08/13/ PY - 2015/05/18/received PY - 2015/07/20/revised PY - 2015/08/10/accepted PY - 2015/8/26/entrez PY - 2015/8/26/pubmed PY - 2016/8/19/medline KW - Asthma KW - Eucapnic voluntary hyperpnoea KW - Exercise-induced bronchoconstriction KW - Reproducibility SP - 1262 EP - 7 JF - Respiratory medicine JO - Respir Med VL - 109 IS - 10 N2 - BACKGROUND: Eucapnic voluntary hyperpnoea (EVH) is considered an effective bronchoprovocation challenge for identifying exercise-induced bronchoconstriction (EIB). However, the reproducibility of the hyperpnoea-induced bronchoconstriction (HIB) response elicited by EVH remains unknown and was therefore the focus of this study. METHODS: Two cohorts of 16 physically active males (each cohort comprised 8 controls and 8 with physician diagnosis of asthma) participated in two studies of the short- and long-term reproducibility of the bronchoconstrictive response to an EVH test with dry air. EVH was performed on days 0, 7, 14, and 21 (short-term study), and 0, 35, and 70 (long-term study). HIB was diagnosed by a ≥10% fall in forced expiratory volume in 1 s (FEV1) after EVH. RESULTS: On day 0 of the short-term study, FEV1 fell by 2 ± 1% (P < 0.05) and 27 ± 18% (P < 0.01) from pre-to post-EVH in control and HIB-positive groups respectively. The post-EVH fall in FEV1 did not differ across the short-term study test days. In the HIB-positive group, the day-to-day coefficient of variation, reproducibility, and smallest meaningful change for the fall in FEV1 were 12%, 328 mL, and 164 mL, respectively. On day 0 of the long-term study, FEV1 fell by 2 ± 2% and 25 ± 18% (P < 0.01) after EVH in control and HIB-positive groups respectively. The post-EVH fall in FEV1 did not differ across the long-term study test days. In the HIB-positive group, the day-to-day coefficient of variation, reproducibility, and smallest meaningful change for the fall in FEV1 were 10%, 196 mL, and 98 mL respectively. CONCLUSION: The EVH test elicits a reproducible bronchoconstrictive response in physically active males with physician diagnosed asthma. These data thus support the clinical utility of the EVH test for EIB screening and monitoring. SN - 1532-3064 UR - https://www.unboundmedicine.com/medline/citation/26303339/Reproducibility_of_the_bronchoconstrictive_response_to_eucapnic_voluntary_hyperpnoea_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(15)30038-X DB - PRIME DP - Unbound Medicine ER -