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Modulation of Gut Microbiota-Brain Axis by Probiotics, Prebiotics, and Diet.
J Agric Food Chem. 2015 Sep 16; 63(36):7885-95.JA

Abstract

There exists a bidirectional communication system between the gastrointestinal tract and the brain. Increasing evidence shows that gut microbiota can play a critical role in this communication; thus, the concept of a gut microbiota and brain axis is emerging. Here, we review recent findings in the relationship between intestinal microbes and brain function, such as anxiety, depression, stress, autism, learning, and memory. We highlight the advances in modulating brain development and behavior by probiotics, prebiotics, and diet through the gut microbiota-brain axis. A variety of mechanisms including immune, neural, and metabolic pathways may be involved in modulation of the gut microbiota-brain axis. We also discuss some future challenges. A deeper understanding of the relationship between the gut bacteria and their hosts is implicated in developing microbial-based therapeutic strategies for brain disorders.

Authors+Show Affiliations

College of Light Industry and Food Sciences, South China University of Technology , Guangzhou, China.Department of Psychology, Sun Yat-Sen University , Guangzhou, China. Library, South China University of Technology , Guangzhou, China.College of Light Industry and Food Sciences, South China University of Technology , Guangzhou, China.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26306709

Citation

Liu, Xiaofei, et al. "Modulation of Gut Microbiota-Brain Axis By Probiotics, Prebiotics, and Diet." Journal of Agricultural and Food Chemistry, vol. 63, no. 36, 2015, pp. 7885-95.
Liu X, Cao S, Zhang X. Modulation of Gut Microbiota-Brain Axis by Probiotics, Prebiotics, and Diet. J Agric Food Chem. 2015;63(36):7885-95.
Liu, X., Cao, S., & Zhang, X. (2015). Modulation of Gut Microbiota-Brain Axis by Probiotics, Prebiotics, and Diet. Journal of Agricultural and Food Chemistry, 63(36), 7885-95. https://doi.org/10.1021/acs.jafc.5b02404
Liu X, Cao S, Zhang X. Modulation of Gut Microbiota-Brain Axis By Probiotics, Prebiotics, and Diet. J Agric Food Chem. 2015 Sep 16;63(36):7885-95. PubMed PMID: 26306709.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Modulation of Gut Microbiota-Brain Axis by Probiotics, Prebiotics, and Diet. AU - Liu,Xiaofei, AU - Cao,Shangqing, AU - Zhang,Xuewu, Y1 - 2015/09/01/ PY - 2015/8/27/entrez PY - 2015/8/27/pubmed PY - 2016/3/18/medline KW - brain function KW - diet KW - gut microbiota KW - prebiotics KW - probiotics SP - 7885 EP - 95 JF - Journal of agricultural and food chemistry JO - J Agric Food Chem VL - 63 IS - 36 N2 - There exists a bidirectional communication system between the gastrointestinal tract and the brain. Increasing evidence shows that gut microbiota can play a critical role in this communication; thus, the concept of a gut microbiota and brain axis is emerging. Here, we review recent findings in the relationship between intestinal microbes and brain function, such as anxiety, depression, stress, autism, learning, and memory. We highlight the advances in modulating brain development and behavior by probiotics, prebiotics, and diet through the gut microbiota-brain axis. A variety of mechanisms including immune, neural, and metabolic pathways may be involved in modulation of the gut microbiota-brain axis. We also discuss some future challenges. A deeper understanding of the relationship between the gut bacteria and their hosts is implicated in developing microbial-based therapeutic strategies for brain disorders. SN - 1520-5118 UR - https://www.unboundmedicine.com/medline/citation/26306709/Modulation_of_Gut_Microbiota_Brain_Axis_by_Probiotics_Prebiotics_and_Diet_ L2 - https://doi.org/10.1021/acs.jafc.5b02404 DB - PRIME DP - Unbound Medicine ER -