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Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort.
Pediatr Nephrol. 2016 Jan; 31(1):121-9.PN

Abstract

BACKGROUND

Vitamin D plays an important role in the mineral and bone disorder seen in chronic kidney disease (CKD). Deficiency of 25-hydroxyvitamin D (25OHD) is highly prevalent in the adult CKD population.

METHODS

The prevalence and determinants of 25OHD deficiency (defined as a level <20 ng/ml) were examined longitudinally in 506 children in the CKiD cohort. Predictors of secondary hyperparathyroidism and the determinants of 1,25-dihydroxyvitamin D (1,25(OH)2D) levels were also evaluated.

RESULTS

Deficiency of 25OHD was observed in 28 % of the cohort at enrollment. Significant predictors of 25OHD deficiency were older age, non-white race, higher body mass index, assessment during winter, less often than daily milk intake, non-use of nutritional vitamin D supplement and proteinuria. Lower values of glomerular filtration rate (GFR), serum 25OHD, calcium and higher levels of FGF23 were significant determinants of secondary hyperparathyroidism. Lower GFR, low serum 25OHD, nephrotic-range proteinuria, and high FGF23 levels were significant determinants of serum 1,25(OH)2 D levels.

CONCLUSIONS

Deficiency of 25OHD is prevalent in children with CKD and is associated with potentially modifiable risk factors such as milk intake, nutritional vitamin D supplement use, and proteinuria. 25OHD deficiency is a risk factor for secondary hyperparathyroidism and decreased serum 1,25(OH)2D in children with CKD.

Authors+Show Affiliations

Department of Pediatrics, Weill Cornell Medical College, New York, NY, USA. juk2013@med.cornell.edu. , 505 East 70th Street, Box 176, New York, NY, 10021, USA. juk2013@med.cornell.edu.Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.Outcomes after Critical Illness and Surgery Group, Johns Hopkins Hospital, Baltimore, MD, USA.Department of Pediatrics, Weill Cornell Medical College, New York, NY, USA.Department of Pediatrics, Children's Hospital at Montefiore, Albert Einstein College of Medicine, Bronx, NY, USA.Perelman School of Medicine at the University of Pennsylvania, Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, PA, USA.Department of Pediatrics, University of Missouri-Kansas City School of Medicine, Kansas City, MO, USA.Department of Pediatrics, University of California, San Francisco, CA, USA.Department of Medicine, Albert Einstein College of Medicine/Montefiore Medical Center, Bronx, NY, USA.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26307635

Citation

Kumar, Juhi, et al. "Prevalence and Correlates of 25-hydroxyvitamin D Deficiency in the Chronic Kidney Disease in Children (CKiD) Cohort." Pediatric Nephrology (Berlin, Germany), vol. 31, no. 1, 2016, pp. 121-9.
Kumar J, McDermott K, Abraham AG, et al. Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort. Pediatr Nephrol. 2016;31(1):121-9.
Kumar, J., McDermott, K., Abraham, A. G., Friedman, L. A., Johnson, V. L., Kaskel, F. J., Furth, S. L., Warady, B. A., Portale, A. A., & Melamed, M. L. (2016). Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort. Pediatric Nephrology (Berlin, Germany), 31(1), 121-9. https://doi.org/10.1007/s00467-015-3190-7
Kumar J, et al. Prevalence and Correlates of 25-hydroxyvitamin D Deficiency in the Chronic Kidney Disease in Children (CKiD) Cohort. Pediatr Nephrol. 2016;31(1):121-9. PubMed PMID: 26307635.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence and correlates of 25-hydroxyvitamin D deficiency in the Chronic Kidney Disease in Children (CKiD) cohort. AU - Kumar,Juhi, AU - McDermott,Kelly, AU - Abraham,Alison G, AU - Friedman,Lisa Aronson, AU - Johnson,Valerie L, AU - Kaskel,Frederick J, AU - Furth,Susan L, AU - Warady,Bradley A, AU - Portale,Anthony A, AU - Melamed,Michal L, Y1 - 2015/08/26/ PY - 2015/06/13/received PY - 2015/08/05/accepted PY - 2015/07/29/revised PY - 2015/8/27/entrez PY - 2015/8/27/pubmed PY - 2016/8/30/medline KW - Chronic renal disease KW - Fibroblast growth factor 23 KW - Hyperparathyroidism KW - Mineral metabolism KW - Pediatric SP - 121 EP - 9 JF - Pediatric nephrology (Berlin, Germany) JO - Pediatr Nephrol VL - 31 IS - 1 N2 - BACKGROUND: Vitamin D plays an important role in the mineral and bone disorder seen in chronic kidney disease (CKD). Deficiency of 25-hydroxyvitamin D (25OHD) is highly prevalent in the adult CKD population. METHODS: The prevalence and determinants of 25OHD deficiency (defined as a level <20 ng/ml) were examined longitudinally in 506 children in the CKiD cohort. Predictors of secondary hyperparathyroidism and the determinants of 1,25-dihydroxyvitamin D (1,25(OH)2D) levels were also evaluated. RESULTS: Deficiency of 25OHD was observed in 28 % of the cohort at enrollment. Significant predictors of 25OHD deficiency were older age, non-white race, higher body mass index, assessment during winter, less often than daily milk intake, non-use of nutritional vitamin D supplement and proteinuria. Lower values of glomerular filtration rate (GFR), serum 25OHD, calcium and higher levels of FGF23 were significant determinants of secondary hyperparathyroidism. Lower GFR, low serum 25OHD, nephrotic-range proteinuria, and high FGF23 levels were significant determinants of serum 1,25(OH)2 D levels. CONCLUSIONS: Deficiency of 25OHD is prevalent in children with CKD and is associated with potentially modifiable risk factors such as milk intake, nutritional vitamin D supplement use, and proteinuria. 25OHD deficiency is a risk factor for secondary hyperparathyroidism and decreased serum 1,25(OH)2D in children with CKD. SN - 1432-198X UR - https://www.unboundmedicine.com/medline/citation/26307635/Prevalence_and_correlates_of_25_hydroxyvitamin_D_deficiency_in_the_Chronic_Kidney_Disease_in_Children__CKiD__cohort_ L2 - https://dx.doi.org/10.1007/s00467-015-3190-7 DB - PRIME DP - Unbound Medicine ER -