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Probiotic and lactulose: influence on gastrointestinal flora and pH value in minimal hepatic encephalopathy rats.
Int J Clin Exp Med 2015; 8(6):9996-10000IJ

Abstract

AIM

The present study was conducted to investigate the influence on gastrointestinal flora, counts of bifidobacteria and Enterobacterceae in colon and pH value of gastrointestinal after lactulose and probiotic treatment on rat experimental minimal hepatic encephalopathy (MHE) induced by thioactamide (TAA).

METHODS

MHE was induced by intraperitoneal injection of TAA. 48 male MHE models were then randomly divided into 4 groups: control group (n = 12); MHE group (n = 12) received tap water ad libitum only; lactulose group (n = 12) and probiotics group (n = 12) gavaged respectively with 8 ml/kg of lactulose and 1.5 g/kg of probiotic preparation Golden Bifid (highly concentrated combination probiotic) dissolved in 2 ml of normal saline, once a day for 8 days. The latency of Brainstem auditory evoked potentials (BAEP) I was used as objective index of MHE. Counts of gastrointestinal flora, counts of bifidobacteria and Enterobacterceae in colon and pH value of gastrointestinal were examined respectively.

RESULTS

Compared to MHE group, counts of gastrointestinal flora has greatly decreased, ratio of bifidobacteria and Enterobacterceae has greatly increased, pH value of colon has greatly descended (P < 0.05). However, there was no significant difference between lactulose group and probiotic group (P > 0.05). Both lactulose and probiotics can effectively prevent bacteria translocation and overgrowth, intensify CR, improved value of B/E, and acidify intestinal, decreased pH value of colon.

CONCLUSION

Probiotic compound Golden Bifid is as useful as lactulose for the prevention and treatment of MHE. Probiotic therapy may be a safe, natural, well-tolerated therapy appropriate for the long-term treatment of MHE.

Authors+Show Affiliations

Department of Gastroenterology, Guangzhou First People's Hospital, Guangzhou Medical University Guangdong Province, China ; Department of Gastroenterology, Guangzhou Nansha Central Hospital Guangdong Province, China.Department of Gastroenterology, Guangzhou First People's Hospital, Guangzhou Medical University Guangdong Province, China ; Department of Gastroenterology, Guangzhou Nansha Central Hospital Guangdong Province, China.Department of Digestive Diseases, Affiliated Twelfth People's Municipal Hospital, Guangzhou Medical College Guangzhou 510620, Guangdong Province, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26309689

Citation

Jiang, Shu-Man, et al. "Probiotic and Lactulose: Influence On Gastrointestinal Flora and pH Value in Minimal Hepatic Encephalopathy Rats." International Journal of Clinical and Experimental Medicine, vol. 8, no. 6, 2015, pp. 9996-10000.
Jiang SM, Jia L, Zhang MH. Probiotic and lactulose: influence on gastrointestinal flora and pH value in minimal hepatic encephalopathy rats. Int J Clin Exp Med. 2015;8(6):9996-10000.
Jiang, S. M., Jia, L., & Zhang, M. H. (2015). Probiotic and lactulose: influence on gastrointestinal flora and pH value in minimal hepatic encephalopathy rats. International Journal of Clinical and Experimental Medicine, 8(6), pp. 9996-10000.
Jiang SM, Jia L, Zhang MH. Probiotic and Lactulose: Influence On Gastrointestinal Flora and pH Value in Minimal Hepatic Encephalopathy Rats. Int J Clin Exp Med. 2015;8(6):9996-10000. PubMed PMID: 26309689.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Probiotic and lactulose: influence on gastrointestinal flora and pH value in minimal hepatic encephalopathy rats. AU - Jiang,Shu-Man, AU - Jia,Lin, AU - Zhang,Mei-Hua, Y1 - 2015/06/15/ PY - 2015/03/27/received PY - 2015/06/04/accepted PY - 2015/8/27/entrez PY - 2015/8/27/pubmed PY - 2015/8/27/medline KW - Minimal hepatic encephalopathy KW - PH value KW - gastrointestinal flora KW - lactulose KW - probiotics SP - 9996 EP - 10000 JF - International journal of clinical and experimental medicine JO - Int J Clin Exp Med VL - 8 IS - 6 N2 - AIM: The present study was conducted to investigate the influence on gastrointestinal flora, counts of bifidobacteria and Enterobacterceae in colon and pH value of gastrointestinal after lactulose and probiotic treatment on rat experimental minimal hepatic encephalopathy (MHE) induced by thioactamide (TAA). METHODS: MHE was induced by intraperitoneal injection of TAA. 48 male MHE models were then randomly divided into 4 groups: control group (n = 12); MHE group (n = 12) received tap water ad libitum only; lactulose group (n = 12) and probiotics group (n = 12) gavaged respectively with 8 ml/kg of lactulose and 1.5 g/kg of probiotic preparation Golden Bifid (highly concentrated combination probiotic) dissolved in 2 ml of normal saline, once a day for 8 days. The latency of Brainstem auditory evoked potentials (BAEP) I was used as objective index of MHE. Counts of gastrointestinal flora, counts of bifidobacteria and Enterobacterceae in colon and pH value of gastrointestinal were examined respectively. RESULTS: Compared to MHE group, counts of gastrointestinal flora has greatly decreased, ratio of bifidobacteria and Enterobacterceae has greatly increased, pH value of colon has greatly descended (P < 0.05). However, there was no significant difference between lactulose group and probiotic group (P > 0.05). Both lactulose and probiotics can effectively prevent bacteria translocation and overgrowth, intensify CR, improved value of B/E, and acidify intestinal, decreased pH value of colon. CONCLUSION: Probiotic compound Golden Bifid is as useful as lactulose for the prevention and treatment of MHE. Probiotic therapy may be a safe, natural, well-tolerated therapy appropriate for the long-term treatment of MHE. SN - 1940-5901 UR - https://www.unboundmedicine.com/medline/citation/26309689/Probiotic_and_lactulose:_influence_on_gastrointestinal_flora_and_pH_value_in_minimal_hepatic_encephalopathy_rats_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/26309689/ DB - PRIME DP - Unbound Medicine ER -