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Molecular Genetic Advances in Uveitis.
Prog Mol Biol Transl Sci. 2015; 134:283-98.PM

Abstract

Uveitis is usually considered as an intraocular inflammation characterized by variety of clinical features. Behcet's disease (BD), Vogt-Koyanagi-Harada (VKH) syndrome, acute anterior uveitis (AAU), and birdshot chorioretinopathy (BCR) are examples of noninfectious forms of uveitis. Although the precise pathogenesis remains unclear, accumulating evidence shows that complex genetic backgrounds coupled with an aberrant immune response may be implicated in the development of uveitis. The complement and pattern recognition systems are both important factors of the innate immune system and are involved in the pathogenesis of uveitis. Copy number variants (CNVs) of complement component 4 have been found to be associated with BD and VKH syndrome, but not with AAU. Several CNVs and gene polymorphisms of toll-like receptors were found to be associated with BD. Leukocytes are an important part of the adaptive immune system and various molecules on these cells play an important role in the development of uveitis. Genes encoding for human leukocyte antigens (HLAs) have been shown to be associated with certain uveitis entities, including BD (HLA-B51), VKH syndrome (HLA-DR4, DRB1/DQA1), AAU (HLA-B27), and BCR (HLA-A29). Genome wide association studies showed that the IL-23R locus was a shared risk factor for multiple uveitis entities including BD, AAU, and VKH syndrome. In addition, various other non-HLA genes are also associated with BD or VKH syndrome, such as IL-10, STAT4, STAT3, and UBAC2. These studies support the hypothesis that genetic factors play a key role in the pathogenesis of uveitis.

Authors+Show Affiliations

The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing, PR China.University Eye Clinic Maastricht, Maastricht, The Netherlands.The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing, PR China. Electronic address: peizengycmu@126.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26310161

Citation

Hou, Shengping, et al. "Molecular Genetic Advances in Uveitis." Progress in Molecular Biology and Translational Science, vol. 134, 2015, pp. 283-98.
Hou S, Kijlstra A, Yang P. Molecular Genetic Advances in Uveitis. Prog Mol Biol Transl Sci. 2015;134:283-98.
Hou, S., Kijlstra, A., & Yang, P. (2015). Molecular Genetic Advances in Uveitis. Progress in Molecular Biology and Translational Science, 134, 283-98. https://doi.org/10.1016/bs.pmbts.2015.04.009
Hou S, Kijlstra A, Yang P. Molecular Genetic Advances in Uveitis. Prog Mol Biol Transl Sci. 2015;134:283-98. PubMed PMID: 26310161.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Molecular Genetic Advances in Uveitis. AU - Hou,Shengping, AU - Kijlstra,Aize, AU - Yang,Peizeng, PY - 2015/8/28/entrez PY - 2015/8/28/pubmed PY - 2016/2/16/medline KW - Acute anterior uveitis KW - BD KW - Behcet's disease KW - Birdshot retinochoroidopathy KW - C4 KW - HLA KW - IL-10 KW - IL-23R KW - Immunology KW - STAT3 KW - STAT4 KW - UBAC2 KW - Uveitis KW - VKH KW - Vogt–Koyanagi–Harada syndrome SP - 283 EP - 98 JF - Progress in molecular biology and translational science JO - Prog Mol Biol Transl Sci VL - 134 N2 - Uveitis is usually considered as an intraocular inflammation characterized by variety of clinical features. Behcet's disease (BD), Vogt-Koyanagi-Harada (VKH) syndrome, acute anterior uveitis (AAU), and birdshot chorioretinopathy (BCR) are examples of noninfectious forms of uveitis. Although the precise pathogenesis remains unclear, accumulating evidence shows that complex genetic backgrounds coupled with an aberrant immune response may be implicated in the development of uveitis. The complement and pattern recognition systems are both important factors of the innate immune system and are involved in the pathogenesis of uveitis. Copy number variants (CNVs) of complement component 4 have been found to be associated with BD and VKH syndrome, but not with AAU. Several CNVs and gene polymorphisms of toll-like receptors were found to be associated with BD. Leukocytes are an important part of the adaptive immune system and various molecules on these cells play an important role in the development of uveitis. Genes encoding for human leukocyte antigens (HLAs) have been shown to be associated with certain uveitis entities, including BD (HLA-B51), VKH syndrome (HLA-DR4, DRB1/DQA1), AAU (HLA-B27), and BCR (HLA-A29). Genome wide association studies showed that the IL-23R locus was a shared risk factor for multiple uveitis entities including BD, AAU, and VKH syndrome. In addition, various other non-HLA genes are also associated with BD or VKH syndrome, such as IL-10, STAT4, STAT3, and UBAC2. These studies support the hypothesis that genetic factors play a key role in the pathogenesis of uveitis. SN - 1878-0814 UR - https://www.unboundmedicine.com/medline/citation/26310161/Molecular_Genetic_Advances_in_Uveitis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1877-1173(15)00070-8 DB - PRIME DP - Unbound Medicine ER -