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Vitamin D supplementation for the prevention of childhood acute respiratory infections: a systematic review of randomised controlled trials.
Br J Nutr 2015; 114(7):1026-34BJ

Abstract

Results from recent trials assessing the effect of vitamin D supplementation on the prevention of childhood acute respiratory infections (ARI) have been inconsistent. In the present study, we determined whether vitamin D supplementation prevents ARI in healthy children and repeated infections in children with previous ARI. We conducted a systematic literature search using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials. The search included only randomised controlled clinical trials (RCT) comparing vitamin D supplementation with either placebo or no intervention in children younger than 18 years of age. We identified seven RCT and found that the summary estimates were not statistically significantly associated with a reduction in the risk of ARI (relative risk (RR) 0·79, 95% CI 0·55, 1·13), all-cause mortality (RR 1·18, 95% CI 0·71, 1·94), or the rate of hospital admission due to respiratory infection in healthy children (RR 0·95, 95% CI 0·72, 1·26). However, in children previously diagnosed with asthma, vitamin D supplementation resulted in a 74% reduction in the risk of asthma exacerbation (RR 0·26, 95% CI 0·11, 0·59; test of heterogeneity, I 2= 0·0%). Our findings indicate a lack of evidence supporting the routine use of vitamin D supplementation for the prevention of ARI in healthy children; however, they suggest that such supplementation may benefit children previously diagnosed with asthma. Due to the heterogeneity of the included studies and possible publication biases related to this field, these results should be interpreted with caution.

Authors+Show Affiliations

Second Affiliated Hospital of Anhui Medical University,Hefei230601,Anhui Province,People's Republic of China.Shaoxing Center for Disease Control and Prevention,Shaoxing312000,Zhejiang Province,People's Republic of China.Huzhou Center for Disease Control and Prevention,Huzhou313000,Zhejiang Province,People's Republic of China.Department of Maternal and Child Health,School of Public Health, Anhui Medical University,Hefei230032,Anhui,People's Republic of China.Anhui Institute of Schistosomiasis Control,Hefei230061,Anhui Province,People's Republic of China.Anhui Provincial Family Planning Institute of Science and Technology,Hefei230031,Anhui Province,People's Republic of China.Anhui Provincial Family Planning Institute of Science and Technology,Hefei230031,Anhui Province,People's Republic of China.Anhui Provincial Family Planning Institute of Science and Technology,Hefei230031,Anhui Province,People's Republic of China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Review
Systematic Review

Language

eng

PubMed ID

26310436

Citation

Xiao, Limin, et al. "Vitamin D Supplementation for the Prevention of Childhood Acute Respiratory Infections: a Systematic Review of Randomised Controlled Trials." The British Journal of Nutrition, vol. 114, no. 7, 2015, pp. 1026-34.
Xiao L, Xing C, Yang Z, et al. Vitamin D supplementation for the prevention of childhood acute respiratory infections: a systematic review of randomised controlled trials. Br J Nutr. 2015;114(7):1026-34.
Xiao, L., Xing, C., Yang, Z., Xu, S., Wang, M., Du, H., ... Huang, Z. (2015). Vitamin D supplementation for the prevention of childhood acute respiratory infections: a systematic review of randomised controlled trials. The British Journal of Nutrition, 114(7), pp. 1026-34. doi:10.1017/S000711451500207X.
Xiao L, et al. Vitamin D Supplementation for the Prevention of Childhood Acute Respiratory Infections: a Systematic Review of Randomised Controlled Trials. Br J Nutr. 2015 Oct 14;114(7):1026-34. PubMed PMID: 26310436.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D supplementation for the prevention of childhood acute respiratory infections: a systematic review of randomised controlled trials. AU - Xiao,Limin, AU - Xing,Chao, AU - Yang,Zhongrong, AU - Xu,Shaojun, AU - Wang,Min, AU - Du,Huarong, AU - Liu,Kai, AU - Huang,Zhaohui, Y1 - 2015/08/27/ PY - 2015/8/28/entrez PY - 2015/8/28/pubmed PY - 2015/12/19/medline KW - Acute respiratory infections KW - Randomised controlled trials KW - Vitamin D SP - 1026 EP - 34 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 114 IS - 7 N2 - Results from recent trials assessing the effect of vitamin D supplementation on the prevention of childhood acute respiratory infections (ARI) have been inconsistent. In the present study, we determined whether vitamin D supplementation prevents ARI in healthy children and repeated infections in children with previous ARI. We conducted a systematic literature search using MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials. The search included only randomised controlled clinical trials (RCT) comparing vitamin D supplementation with either placebo or no intervention in children younger than 18 years of age. We identified seven RCT and found that the summary estimates were not statistically significantly associated with a reduction in the risk of ARI (relative risk (RR) 0·79, 95% CI 0·55, 1·13), all-cause mortality (RR 1·18, 95% CI 0·71, 1·94), or the rate of hospital admission due to respiratory infection in healthy children (RR 0·95, 95% CI 0·72, 1·26). However, in children previously diagnosed with asthma, vitamin D supplementation resulted in a 74% reduction in the risk of asthma exacerbation (RR 0·26, 95% CI 0·11, 0·59; test of heterogeneity, I 2= 0·0%). Our findings indicate a lack of evidence supporting the routine use of vitamin D supplementation for the prevention of ARI in healthy children; however, they suggest that such supplementation may benefit children previously diagnosed with asthma. Due to the heterogeneity of the included studies and possible publication biases related to this field, these results should be interpreted with caution. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/26310436/full_citation L2 - https://www.cambridge.org/core/product/identifier/S000711451500207X/type/journal_article DB - PRIME DP - Unbound Medicine ER -