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Risk of familial classical Hodgkin lymphoma by relationship, histology, age, and sex: a joint study from five Nordic countries.
Blood 2015; 126(17):1990-5Blood

Abstract

We aimed to provide the familial risk of classical Hodgkin lymphoma (HL) by relationship, histology, age at diagnosis, and sex. A cohort of 57,475 first-degree relatives of 13,922 HL patients diagnosed between 1955 and 2009 in 5 European countries was observed for HL incidence. The overall lifetime cumulative risk (CR) of HL in first-degree relatives of a patient with HL was 0.6%, which represents a threefold (standardized incidence ratio [SIR], 3.3; 95% confidence interval [CI], 2.8-3.9) increased risk over the general population risk. The risk in siblings (6.0-fold; 95% CI, 4.8- to 7.4-fold) was significantly higher than in parents and/or children (2.1-fold; 95% CI, 1.6- to 2.6-fold). Very high lifetime risk of HL was found for those with multiple affected first-degree relatives (13-fold; 95% CI, 2.8- to 39-fold) and for same-sex twins (57-fold; 95% CI, 21- to 125-fold). We found high familial risks between some concordant histologic subtypes of HL such as lymphocyte-rich (81-fold; 95% CI, 30- to 177-fold) and nodular sclerosis (4.6-fold; 95% CI, 2.9- to 7.0-fold) and also between some discordant subtypes. The familial risk in sisters (9.4-fold; 95% CI, 5.9- to 14-fold) was higher than in brothers (4.5-fold; 95% CI, 2.9- to 6.7-fold) or unlike-sex siblings (5.9-fold; 95% CI, 4.3- to 8.1-fold). The lifetime risk of HL was higher when first-degree relatives were diagnosed at early ages (before age 30 years). This study provides tangible absolute risk estimates for relatives of HL patients, which can be used as a sex-, age-, and family history-based risk calculator for classical HL by oncologists and genetic counselors.

Authors+Show Affiliations

Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany;Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany; Division of Preventive Oncology, National Center for Tumor Diseases (NCT), Heidelberg, Germany;Finnish Cancer Registry, Institute for Statistical and Epidemiological Cancer Research, Helsinki, Finland; School of Health Sciences, University of Tampere, Tampere, Finland;Danish Cancer Society Research Center, Copenhagen, Denmark;Icelandic Cancer Registry, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland;Center for Primary Health Care Research, Lund University, Malmö, Sweden; and.Norwegian Cancer Registry, Oslo, Norway.Division of Molecular Genetic Epidemiology, German Cancer Research Center, Heidelberg, Germany; Center for Primary Health Care Research, Lund University, Malmö, Sweden; and.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26311361

Citation

Kharazmi, Elham, et al. "Risk of Familial Classical Hodgkin Lymphoma By Relationship, Histology, Age, and Sex: a Joint Study From Five Nordic Countries." Blood, vol. 126, no. 17, 2015, pp. 1990-5.
Kharazmi E, Fallah M, Pukkala E, et al. Risk of familial classical Hodgkin lymphoma by relationship, histology, age, and sex: a joint study from five Nordic countries. Blood. 2015;126(17):1990-5.
Kharazmi, E., Fallah, M., Pukkala, E., Olsen, J. H., Tryggvadottir, L., Sundquist, K., ... Hemminki, K. (2015). Risk of familial classical Hodgkin lymphoma by relationship, histology, age, and sex: a joint study from five Nordic countries. Blood, 126(17), pp. 1990-5. doi:10.1182/blood-2015-04-639781.
Kharazmi E, et al. Risk of Familial Classical Hodgkin Lymphoma By Relationship, Histology, Age, and Sex: a Joint Study From Five Nordic Countries. Blood. 2015 Oct 22;126(17):1990-5. PubMed PMID: 26311361.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk of familial classical Hodgkin lymphoma by relationship, histology, age, and sex: a joint study from five Nordic countries. AU - Kharazmi,Elham, AU - Fallah,Mahdi, AU - Pukkala,Eero, AU - Olsen,Jörgen H, AU - Tryggvadottir,Laufey, AU - Sundquist,Kristina, AU - Tretli,Steinar, AU - Hemminki,Kari, Y1 - 2015/08/26/ PY - 2015/04/10/received PY - 2015/08/14/accepted PY - 2015/8/28/entrez PY - 2015/8/28/pubmed PY - 2016/2/13/medline SP - 1990 EP - 5 JF - Blood JO - Blood VL - 126 IS - 17 N2 - We aimed to provide the familial risk of classical Hodgkin lymphoma (HL) by relationship, histology, age at diagnosis, and sex. A cohort of 57,475 first-degree relatives of 13,922 HL patients diagnosed between 1955 and 2009 in 5 European countries was observed for HL incidence. The overall lifetime cumulative risk (CR) of HL in first-degree relatives of a patient with HL was 0.6%, which represents a threefold (standardized incidence ratio [SIR], 3.3; 95% confidence interval [CI], 2.8-3.9) increased risk over the general population risk. The risk in siblings (6.0-fold; 95% CI, 4.8- to 7.4-fold) was significantly higher than in parents and/or children (2.1-fold; 95% CI, 1.6- to 2.6-fold). Very high lifetime risk of HL was found for those with multiple affected first-degree relatives (13-fold; 95% CI, 2.8- to 39-fold) and for same-sex twins (57-fold; 95% CI, 21- to 125-fold). We found high familial risks between some concordant histologic subtypes of HL such as lymphocyte-rich (81-fold; 95% CI, 30- to 177-fold) and nodular sclerosis (4.6-fold; 95% CI, 2.9- to 7.0-fold) and also between some discordant subtypes. The familial risk in sisters (9.4-fold; 95% CI, 5.9- to 14-fold) was higher than in brothers (4.5-fold; 95% CI, 2.9- to 6.7-fold) or unlike-sex siblings (5.9-fold; 95% CI, 4.3- to 8.1-fold). The lifetime risk of HL was higher when first-degree relatives were diagnosed at early ages (before age 30 years). This study provides tangible absolute risk estimates for relatives of HL patients, which can be used as a sex-, age-, and family history-based risk calculator for classical HL by oncologists and genetic counselors. SN - 1528-0020 UR - https://www.unboundmedicine.com/medline/citation/26311361/full_citation L2 - http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=26311361 DB - PRIME DP - Unbound Medicine ER -