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Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases.
Curr Top Med Chem. 2016; 16(8):858-66.CT

Abstract

Coenzyme Q10 (CoQ10) is a component of electron transport chain and acts as an antioxidant. It is also used for preventing neurodegeneration against mitochondrial deficiency and oxidative stress. Therefore, CoQ10 has received increasing attention as therapeutic and preventive intervention for neurodegenerative diseases. This review article focuses mainly on the structure of CoQ10, the function of CoQ10 and the relationship between mitochondrial impairment, oxidative stress and neurodegenerative diseases. In addition, the effects of CoQ10 on Alzheimer's disease, Parkinson's disease, and Huntington's disease are also discussed. Finally, future perspectives regarding development of successful treatment for neurodegenerative diseases are proposed.

Authors+Show Affiliations

Key Laboratory of Modern Toxicology of Shenzhen, Medical Key Laboratory of Guangdong Province, Medical Key Laboratory of Health Toxicology of Shenzhen, Shenzhen Center for Disease Control and Prevention, Shenzhen, 518055, China. xifeiyang@gmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26311425

Citation

Yang, Xifei, et al. "Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases." Current Topics in Medicinal Chemistry, vol. 16, no. 8, 2016, pp. 858-66.
Yang X, Zhang Y, Xu H, et al. Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases. Curr Top Med Chem. 2016;16(8):858-66.
Yang, X., Zhang, Y., Xu, H., Luo, X., Yu, J., Liu, J., & Chang, R. C. (2016). Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases. Current Topics in Medicinal Chemistry, 16(8), 858-66.
Yang X, et al. Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases. Curr Top Med Chem. 2016;16(8):858-66. PubMed PMID: 26311425.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases. AU - Yang,Xifei, AU - Zhang,Yanling, AU - Xu,Hua, AU - Luo,Xiaobin, AU - Yu,Jun, AU - Liu,Jianjun, AU - Chang,Raymond Chuen-Chung, PY - 2015/01/30/received PY - 2015/07/06/revised PY - 2015/08/03/accepted PY - 2015/8/28/entrez PY - 2015/8/28/pubmed PY - 2016/9/2/medline SP - 858 EP - 66 JF - Current topics in medicinal chemistry JO - Curr Top Med Chem VL - 16 IS - 8 N2 - Coenzyme Q10 (CoQ10) is a component of electron transport chain and acts as an antioxidant. It is also used for preventing neurodegeneration against mitochondrial deficiency and oxidative stress. Therefore, CoQ10 has received increasing attention as therapeutic and preventive intervention for neurodegenerative diseases. This review article focuses mainly on the structure of CoQ10, the function of CoQ10 and the relationship between mitochondrial impairment, oxidative stress and neurodegenerative diseases. In addition, the effects of CoQ10 on Alzheimer's disease, Parkinson's disease, and Huntington's disease are also discussed. Finally, future perspectives regarding development of successful treatment for neurodegenerative diseases are proposed. SN - 1873-4294 UR - https://www.unboundmedicine.com/medline/citation/26311425/Neuroprotection_of_Coenzyme_Q10_in_Neurodegenerative_Diseases_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1568-0266&volume=16&issue=8&spage=858&aulast=Yang DB - PRIME DP - Unbound Medicine ER -