Tags

Type your tag names separated by a space and hit enter

Anti-herpes simplex virus activities of bioactive extracts from Antrodia camphorata mycelia.
Antivir Ther. 2016; 21(5):377-83.AT

Abstract

BACKGROUND

Antrodia camphorata, a traditional Chinese medicine, is widely used in the treatment of liver diseases and cancers. Anti-inflammatory properties have also been described. HSV infection represents one of the most serious public health concerns globally because of its devastating impact. Searching for new antiviral agents, especially those with different mechanisms of action, is a crucial goal and there is an unmet need for alternative and complementary therapy against HSV infection. In this study, anti-herpes screening was performed with extracts from A. camphorata mycelia.

METHODS

MTT assay, fractional inhibitory concentration index and median-effect principle were used to evaluate antiviral activity and to calculate drug combination effect.

RESULTS

Crude ethanol extracts and isolated constituents showed inhibition of HSV replication at a very low concentration. Fraction A and antrodin A showed viral inhibitory effect with reduction of viral cell-to-cell spread. In addition, neither fraction A nor antrodin A showed interaction in combination with acyclovir.

CONCLUSIONS

A. camphorata mycelia and antrodin A might have potential use as anti-HSV agents and are promising candidates for future antiviral drug design.

Links

Publisher Full Text (DOI)

Authors+Show Affiliations

He YC
Chongqing Academy of Chinese Materia Medica, Chongqing, China.
Lu ZH
No affiliation info available
Shi P
No affiliation info available
Hao JC
No affiliation info available
Zhao ZJ
No affiliation info available
Xie HT
No affiliation info available
Mao P
No affiliation info available
Chen SJ
No affiliation info available

MeSH

AcyclovirAnimalsAntiviral AgentsAntrodiaChlorocebus aethiopsDrugs, Chinese HerbalHerpes SimplexHerpesvirus 1, HumanHerpesvirus 2, HumanHumansMaleic AnhydridesMedicine, Chinese TraditionalMicrobial Sensitivity TestsMyceliumVero CellsViral Plaque AssayVirus Replication

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26313544

Citation

He, Yuan-Chuan, et al. "Anti-herpes Simplex Virus Activities of Bioactive Extracts From Antrodia Camphorata Mycelia." Antiviral Therapy, vol. 21, no. 5, 2016, pp. 377-83.
He YC, Lu ZH, Shi P, et al. Anti-herpes simplex virus activities of bioactive extracts from Antrodia camphorata mycelia. Antivir Ther. 2016;21(5):377-83.
He, Y. C., Lu, Z. H., Shi, P., Hao, J. C., Zhao, Z. J., Xie, H. T., Mao, P., & Chen, S. J. (2016). Anti-herpes simplex virus activities of bioactive extracts from Antrodia camphorata mycelia. Antiviral Therapy, 21(5), 377-83. https://doi.org/10.3851/IMP2988
He YC, et al. Anti-herpes Simplex Virus Activities of Bioactive Extracts From Antrodia Camphorata Mycelia. Antivir Ther. 2016;21(5):377-83. PubMed PMID: 26313544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-herpes simplex virus activities of bioactive extracts from Antrodia camphorata mycelia. AU - He,Yuan-Chuan, AU - Lu,Zeng-Hui, AU - Shi,Ping, AU - Hao,Jing-Chao, AU - Zhao,Zong-Jie, AU - Xie,Hai-Tao, AU - Mao,Ping, AU - Chen,Shi-Jiang, Y1 - 2015/08/27/ PY - 2015/08/07/accepted PY - 2015/8/28/entrez PY - 2015/8/28/pubmed PY - 2018/1/23/medline SP - 377 EP - 83 JF - Antiviral therapy JO - Antivir Ther VL - 21 IS - 5 N2 - BACKGROUND: Antrodia camphorata, a traditional Chinese medicine, is widely used in the treatment of liver diseases and cancers. Anti-inflammatory properties have also been described. HSV infection represents one of the most serious public health concerns globally because of its devastating impact. Searching for new antiviral agents, especially those with different mechanisms of action, is a crucial goal and there is an unmet need for alternative and complementary therapy against HSV infection. In this study, anti-herpes screening was performed with extracts from A. camphorata mycelia. METHODS: MTT assay, fractional inhibitory concentration index and median-effect principle were used to evaluate antiviral activity and to calculate drug combination effect. RESULTS: Crude ethanol extracts and isolated constituents showed inhibition of HSV replication at a very low concentration. Fraction A and antrodin A showed viral inhibitory effect with reduction of viral cell-to-cell spread. In addition, neither fraction A nor antrodin A showed interaction in combination with acyclovir. CONCLUSIONS: A. camphorata mycelia and antrodin A might have potential use as anti-HSV agents and are promising candidates for future antiviral drug design. SN - 2040-2058 UR - https://www.unboundmedicine.com/medline/citation/26313544/Anti_herpes_simplex_virus_activities_of_bioactive_extracts_from_Antrodia_camphorata_mycelia_ DB - PRIME DP - Unbound Medicine ER -