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Separate and combined effects of gabapentin and [INCREMENT]9-tetrahydrocannabinol in humans discriminating [INCREMENT]9-tetrahydrocannabinol.
Behav Pharmacol. 2016 Apr; 27(2-3 Spec Issue):215-24.BP

Abstract

The aim of the present study was to examine a potential mechanism of action of gabapentin to manage cannabis-use disorders by determining the interoceptive effects of gabapentin in cannabis users discriminating [INCREMENT]-tetrahydrocannabinol ([INCREMENT]-THC) using a pharmacologically selective drug-discrimination procedure. Eight cannabis users learned to discriminate 30 mg oral [INCREMENT]-THC from placebo and then received gabapentin (600 and 1200 mg), [INCREMENT]-THC (5, 15, and 30 mg), and placebo alone and in combination. Self-report, task performance, and physiological measures were also collected. [INCREMENT]-THC served as a discriminative stimulus, produced positive subjective effects, elevated heart rate, and impaired psychomotor performance. Both doses of gabapentin substituted for the [INCREMENT]-THC discriminative stimulus and engendered subjective and performance-impairing effects that overlapped with those of [INCREMENT]-THC when administered alone. When administered concurrently, gabapentin shifted the discriminative-stimulus effects of [INCREMENT]-THC leftward/upward, and combinations of [INCREMENT]-THC and gabapentin generally produced larger effects on cannabinoid-sensitive outcomes relative to [INCREMENT]-THC alone. These results suggest that one mechanism by which gabapentin might facilitate cannabis abstinence is by producing effects that overlap with those of cannabinoids.

Authors+Show Affiliations

Departments of aBehavioral SciencebPsychiatrycInternal Medicine, College of MedicinedDepartment of Psychology, College of Arts and Sciences, University of Kentucky, Lexington, Kentucky, USA.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

26313650

Citation

Lile, Joshua A., et al. "Separate and Combined Effects of Gabapentin and [INCREMENT]9-tetrahydrocannabinol in Humans Discriminating [INCREMENT]9-tetrahydrocannabinol." Behavioural Pharmacology, vol. 27, no. 2-3 Spec Issue, 2016, pp. 215-24.
Lile JA, Wesley MJ, Kelly TH, et al. Separate and combined effects of gabapentin and [INCREMENT]9-tetrahydrocannabinol in humans discriminating [INCREMENT]9-tetrahydrocannabinol. Behav Pharmacol. 2016;27(2-3 Spec Issue):215-24.
Lile, J. A., Wesley, M. J., Kelly, T. H., & Hays, L. R. (2016). Separate and combined effects of gabapentin and [INCREMENT]9-tetrahydrocannabinol in humans discriminating [INCREMENT]9-tetrahydrocannabinol. Behavioural Pharmacology, 27(2-3 Spec Issue), 215-24. https://doi.org/10.1097/FBP.0000000000000187
Lile JA, et al. Separate and Combined Effects of Gabapentin and [INCREMENT]9-tetrahydrocannabinol in Humans Discriminating [INCREMENT]9-tetrahydrocannabinol. Behav Pharmacol. 2016;27(2-3 Spec Issue):215-24. PubMed PMID: 26313650.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Separate and combined effects of gabapentin and [INCREMENT]9-tetrahydrocannabinol in humans discriminating [INCREMENT]9-tetrahydrocannabinol. AU - Lile,Joshua A, AU - Wesley,Michael J, AU - Kelly,Thomas H, AU - Hays,Lon R, PY - 2015/8/28/entrez PY - 2015/8/28/pubmed PY - 2016/12/15/medline SP - 215 EP - 24 JF - Behavioural pharmacology JO - Behav Pharmacol VL - 27 IS - 2-3 Spec Issue N2 - The aim of the present study was to examine a potential mechanism of action of gabapentin to manage cannabis-use disorders by determining the interoceptive effects of gabapentin in cannabis users discriminating [INCREMENT]-tetrahydrocannabinol ([INCREMENT]-THC) using a pharmacologically selective drug-discrimination procedure. Eight cannabis users learned to discriminate 30 mg oral [INCREMENT]-THC from placebo and then received gabapentin (600 and 1200 mg), [INCREMENT]-THC (5, 15, and 30 mg), and placebo alone and in combination. Self-report, task performance, and physiological measures were also collected. [INCREMENT]-THC served as a discriminative stimulus, produced positive subjective effects, elevated heart rate, and impaired psychomotor performance. Both doses of gabapentin substituted for the [INCREMENT]-THC discriminative stimulus and engendered subjective and performance-impairing effects that overlapped with those of [INCREMENT]-THC when administered alone. When administered concurrently, gabapentin shifted the discriminative-stimulus effects of [INCREMENT]-THC leftward/upward, and combinations of [INCREMENT]-THC and gabapentin generally produced larger effects on cannabinoid-sensitive outcomes relative to [INCREMENT]-THC alone. These results suggest that one mechanism by which gabapentin might facilitate cannabis abstinence is by producing effects that overlap with those of cannabinoids. SN - 1473-5849 UR - https://www.unboundmedicine.com/medline/citation/26313650/Separate_and_combined_effects_of_gabapentin_and_[INCREMENT]9_tetrahydrocannabinol_in_humans_discriminating_[INCREMENT]9_tetrahydrocannabinol_ L2 - https://doi.org/10.1097/FBP.0000000000000187 DB - PRIME DP - Unbound Medicine ER -