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Nut consumption is inversely associated with both cancer and total mortality in a Mediterranean population: prospective results from the Moli-sani study.
Br J Nutr 2015; 114(5):804-11BJ

Abstract

Nut intake has been associated with reduced inflammatory status and lower risk of CVD and mortality. The aim of this study was to examine the relationship between nut consumption and mortality and the role of inflammation. We conducted a population-based prospective investigation on 19 386 subjects enrolled in the Moli-sani study. Food intake was recorded by the Italian version of the European Project Investigation into Cancer and Nutrition FFQ. C-reactive protein, leucocyte and platelet counts and the neutrophil:lymphocyte ratio were used as biomarkers of low-grade inflammation. Hazard ratios (HR) were calculated using multivariable Cox proportional hazard models. During a median follow-up of 4·3 years, 334 all-cause deaths occurred. As compared with subjects who never ate nuts, rare intake (≤2 times/month) was inversely associated with mortality (multivariable HR=0·68; 95 % CI 0·54, 0·87). At intake ≥8 times/month, a greater protection was observed (HR=0·53; 0·32, 0·90). Nut intake (v. no intake) conveyed a higher protection to individuals poorly adhering to the Mediterranean diet (MD). A significant reduction in cancer deaths (HR=0·64; 95 % CI 0·44, 0·94) was also observed, whereas the impact on CVD deaths was limited to an inverse, but not significant, trend. Biomarkers of low-grade inflammation were reduced in nut consumers but did not account for the association with mortality. In conclusion, nut intake was associated with reduced cancer and total mortality. The protection was stronger in individuals with lower adherence to MD, whereas it was similar in high-risk groups (diabetics, obese, smokers or those with the metabolic syndrome), as compared with low-risk subjects. Inflammation did not explain the observed relationship.

Authors+Show Affiliations

1Department of Epidemiology and Prevention,IRCCS Istituto Neurologico Mediterraneo,Neuromed,86077 Pozzilli,Isernia,Italy.1Department of Epidemiology and Prevention,IRCCS Istituto Neurologico Mediterraneo,Neuromed,86077 Pozzilli,Isernia,Italy.1Department of Epidemiology and Prevention,IRCCS Istituto Neurologico Mediterraneo,Neuromed,86077 Pozzilli,Isernia,Italy.1Department of Epidemiology and Prevention,IRCCS Istituto Neurologico Mediterraneo,Neuromed,86077 Pozzilli,Isernia,Italy.1Department of Epidemiology and Prevention,IRCCS Istituto Neurologico Mediterraneo,Neuromed,86077 Pozzilli,Isernia,Italy.1Department of Epidemiology and Prevention,IRCCS Istituto Neurologico Mediterraneo,Neuromed,86077 Pozzilli,Isernia,Italy.1Department of Epidemiology and Prevention,IRCCS Istituto Neurologico Mediterraneo,Neuromed,86077 Pozzilli,Isernia,Italy.1Department of Epidemiology and Prevention,IRCCS Istituto Neurologico Mediterraneo,Neuromed,86077 Pozzilli,Isernia,Italy.1Department of Epidemiology and Prevention,IRCCS Istituto Neurologico Mediterraneo,Neuromed,86077 Pozzilli,Isernia,Italy.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26313936

Citation

Bonaccio, Marialaura, et al. "Nut Consumption Is Inversely Associated With Both Cancer and Total Mortality in a Mediterranean Population: Prospective Results From the Moli-sani Study." The British Journal of Nutrition, vol. 114, no. 5, 2015, pp. 804-11.
Bonaccio M, Di Castelnuovo A, De Curtis A, et al. Nut consumption is inversely associated with both cancer and total mortality in a Mediterranean population: prospective results from the Moli-sani study. Br J Nutr. 2015;114(5):804-11.
Bonaccio, M., Di Castelnuovo, A., De Curtis, A., Costanzo, S., Bracone, F., Persichillo, M., ... Iacoviello, L. (2015). Nut consumption is inversely associated with both cancer and total mortality in a Mediterranean population: prospective results from the Moli-sani study. The British Journal of Nutrition, 114(5), pp. 804-11. doi:10.1017/S0007114515002378.
Bonaccio M, et al. Nut Consumption Is Inversely Associated With Both Cancer and Total Mortality in a Mediterranean Population: Prospective Results From the Moli-sani Study. Br J Nutr. 2015 Sep 14;114(5):804-11. PubMed PMID: 26313936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nut consumption is inversely associated with both cancer and total mortality in a Mediterranean population: prospective results from the Moli-sani study. AU - Bonaccio,Marialaura, AU - Di Castelnuovo,Augusto, AU - De Curtis,Amalia, AU - Costanzo,Simona, AU - Bracone,Francesca, AU - Persichillo,Mariarosaria, AU - Donati,Maria Benedetta, AU - de Gaetano,Giovanni, AU - Iacoviello,Licia, AU - ,, PY - 2015/8/28/entrez PY - 2015/8/28/pubmed PY - 2015/11/11/medline KW - CRP C-reactive protein KW - CVD KW - Cancer KW - Inflammation KW - MD Mediterranean diet KW - Mortality KW - NLR neutrophil:lymphocyte ratio KW - Nuts KW - Stroke SP - 804 EP - 11 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 114 IS - 5 N2 - Nut intake has been associated with reduced inflammatory status and lower risk of CVD and mortality. The aim of this study was to examine the relationship between nut consumption and mortality and the role of inflammation. We conducted a population-based prospective investigation on 19 386 subjects enrolled in the Moli-sani study. Food intake was recorded by the Italian version of the European Project Investigation into Cancer and Nutrition FFQ. C-reactive protein, leucocyte and platelet counts and the neutrophil:lymphocyte ratio were used as biomarkers of low-grade inflammation. Hazard ratios (HR) were calculated using multivariable Cox proportional hazard models. During a median follow-up of 4·3 years, 334 all-cause deaths occurred. As compared with subjects who never ate nuts, rare intake (≤2 times/month) was inversely associated with mortality (multivariable HR=0·68; 95 % CI 0·54, 0·87). At intake ≥8 times/month, a greater protection was observed (HR=0·53; 0·32, 0·90). Nut intake (v. no intake) conveyed a higher protection to individuals poorly adhering to the Mediterranean diet (MD). A significant reduction in cancer deaths (HR=0·64; 95 % CI 0·44, 0·94) was also observed, whereas the impact on CVD deaths was limited to an inverse, but not significant, trend. Biomarkers of low-grade inflammation were reduced in nut consumers but did not account for the association with mortality. In conclusion, nut intake was associated with reduced cancer and total mortality. The protection was stronger in individuals with lower adherence to MD, whereas it was similar in high-risk groups (diabetics, obese, smokers or those with the metabolic syndrome), as compared with low-risk subjects. Inflammation did not explain the observed relationship. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/26313936/Nut_consumption_is_inversely_associated_with_both_cancer_and_total_mortality_in_a_Mediterranean_population:_prospective_results_from_the_Moli_sani_study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114515002378/type/journal_article DB - PRIME DP - Unbound Medicine ER -