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Association of inflammatory bowel disease with asthma risk: A nationwide cohort study.
Allergy Asthma Proc. 2015 Sep-Oct; 36(5):e92-8.AA

Abstract

OBJECTIVE

We evaluated the risk of asthma development in adult patients with inflammatory bowel disease (IBD) in a nationwide population.

METHODS

A retrospective cohort study was conducted by using data retrieved from the Taiwan National Health Insurance Research Database. Patients, ages 20 year or older, with newly diagnosed IBD between 2000 and 2005 were identified and randomly frequency-matched (based on sex, age, and index year) with four times the number of enrollees without IBD from the general population. Both cohorts were followed up until the end of 2011 to examine the incidence of asthma. Cox proportional hazard regression analysis was used to measure the hazard ratios (HR) of asthma in the IBD cohort compared with that in the non-IBD cohort.

RESULTS

The IBD and non-IBD cohorts comprised 5260 patients with IBD and 21,040 participants, respectively. After adjustment for covariates, the IBD cohort exhibited a 1.50-fold increased risk for asthma (HR 1.50, [95% confidence interval {CI}, 1.32-1.71]). Further analysis according to the two major forms of IBD revealed that the adjusted HR of asthma was 1.46 (95% CI, 1.03-2.07) and 1.50 (95% CI, 1.31-1.72) in patients with ulcerative colitis and Crohn's disease, respectively, compared with the non-IBD cohort.

CONCLUSION

After adjustment for comorbidities, patients with IBD were associated with a higher subsequent risk of asthma.

Authors+Show Affiliations

Department of Respiratory Therapy, China Medical University Hospital, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26314810

Citation

Peng, Yi-Hao, et al. "Association of Inflammatory Bowel Disease With Asthma Risk: a Nationwide Cohort Study." Allergy and Asthma Proceedings, vol. 36, no. 5, 2015, pp. e92-8.
Peng YH, Liao WC, Su CH, et al. Association of inflammatory bowel disease with asthma risk: A nationwide cohort study. Allergy Asthma Proc. 2015;36(5):e92-8.
Peng, Y. H., Liao, W. C., Su, C. H., Chen, H. J., Hsia, T. C., Chu, C. C., Liu, C. J., & Kao, C. H. (2015). Association of inflammatory bowel disease with asthma risk: A nationwide cohort study. Allergy and Asthma Proceedings, 36(5), e92-8. https://doi.org/10.2500/aap.2015.36.3869
Peng YH, et al. Association of Inflammatory Bowel Disease With Asthma Risk: a Nationwide Cohort Study. Allergy Asthma Proc. 2015 Sep-Oct;36(5):e92-8. PubMed PMID: 26314810.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of inflammatory bowel disease with asthma risk: A nationwide cohort study. AU - Peng,Yi-Hao, AU - Liao,Wei-Chih, AU - Su,Ching-Hua, AU - Chen,Hsuan-Ju, AU - Hsia,Te-Chun, AU - Chu,Chia-Chen, AU - Liu,Chin-Jung, AU - Kao,Chia-Hung, PY - 2015/8/29/entrez PY - 2015/9/1/pubmed PY - 2016/6/21/medline SP - e92 EP - 8 JF - Allergy and asthma proceedings JO - Allergy Asthma Proc VL - 36 IS - 5 N2 - OBJECTIVE: We evaluated the risk of asthma development in adult patients with inflammatory bowel disease (IBD) in a nationwide population. METHODS: A retrospective cohort study was conducted by using data retrieved from the Taiwan National Health Insurance Research Database. Patients, ages 20 year or older, with newly diagnosed IBD between 2000 and 2005 were identified and randomly frequency-matched (based on sex, age, and index year) with four times the number of enrollees without IBD from the general population. Both cohorts were followed up until the end of 2011 to examine the incidence of asthma. Cox proportional hazard regression analysis was used to measure the hazard ratios (HR) of asthma in the IBD cohort compared with that in the non-IBD cohort. RESULTS: The IBD and non-IBD cohorts comprised 5260 patients with IBD and 21,040 participants, respectively. After adjustment for covariates, the IBD cohort exhibited a 1.50-fold increased risk for asthma (HR 1.50, [95% confidence interval {CI}, 1.32-1.71]). Further analysis according to the two major forms of IBD revealed that the adjusted HR of asthma was 1.46 (95% CI, 1.03-2.07) and 1.50 (95% CI, 1.31-1.72) in patients with ulcerative colitis and Crohn's disease, respectively, compared with the non-IBD cohort. CONCLUSION: After adjustment for comorbidities, patients with IBD were associated with a higher subsequent risk of asthma. SN - 1539-6304 UR - https://www.unboundmedicine.com/medline/citation/26314810/Association_of_inflammatory_bowel_disease_with_asthma_risk:_A_nationwide_cohort_study_ L2 - https://www.ingentaconnect.com/openurl?genre=article&issn=1539-6304&volume=36&issue=5&spage=e92&aulast=Peng DB - PRIME DP - Unbound Medicine ER -