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Hereditary Colorectal Cancer: Genetics and Screening.
Surg Clin North Am. 2015 Oct; 95(5):1067-80.SC

Abstract

Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in men and women in the United States. About 30% of patients with CRC report a family history of CRC. However, only 5% of CRCs arise in the setting of a well-established mendelian inherited disorder. In addition, serrated polyposis is a clinically defined syndrome with multiple serrated polyps in the colorectum and an increased CRC risk for which the genetics are unknown. This article focuses on genetic and clinical aspects of Lynch syndrome, familial adenomatous polyposis, and MUTYH-associated polyposis.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Brosens LA
Department of Pathology, University Medical Center Utrecht (H04-312), Heidelberglaan 100, Utrecht 3584 CX, The Netherlands; Department of Pathology, The Johns Hopkins University School of Medicine, CRB 2, Room 345, 1550 Orleans Street, Baltimore, MD 21231, USA. Electronic address: l.a.a.brosens@umcutrecht.nl.
Offerhaus GJ
Department of Pathology, University Medical Center Utrecht (H04-312), Heidelberglaan 100, Utrecht 3584 CX, The Netherlands.
Giardiello FM
Department of Medicine, Oncology Center, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 431, Baltimore, MD 21205, USA; Department of Pathology, The Johns Hopkins University School of Medicine, 1830 East Monument Street, Room 431, Baltimore, MD 21205, USA. Electronic address: fgiardi@jhmi.edu.

MeSH

Adenomatous Polyposis ColiBiomarkers, TumorColorectal Neoplasms, Hereditary NonpolyposisEarly Detection of CancerGenetic Predisposition to DiseaseHumans

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26315524

Citation

Brosens, Lodewijk A A., et al. "Hereditary Colorectal Cancer: Genetics and Screening." The Surgical Clinics of North America, vol. 95, no. 5, 2015, pp. 1067-80.
Brosens LA, Offerhaus GJ, Giardiello FM. Hereditary Colorectal Cancer: Genetics and Screening. Surg Clin North Am. 2015;95(5):1067-80.
Brosens, L. A., Offerhaus, G. J., & Giardiello, F. M. (2015). Hereditary Colorectal Cancer: Genetics and Screening. The Surgical Clinics of North America, 95(5), 1067-80. https://doi.org/10.1016/j.suc.2015.05.004
Brosens LA, Offerhaus GJ, Giardiello FM. Hereditary Colorectal Cancer: Genetics and Screening. Surg Clin North Am. 2015;95(5):1067-80. PubMed PMID: 26315524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hereditary Colorectal Cancer: Genetics and Screening. AU - Brosens,Lodewijk A A, AU - Offerhaus,G Johan A, AU - Giardiello,Francis M, Y1 - 2015/06/16/ PY - 2015/8/29/entrez PY - 2015/9/1/pubmed PY - 2015/11/6/medline KW - Colorectal cancer KW - Familial adenomatous polyposis KW - Hereditary nonpolyposis colorectal cancer KW - Lynch syndrome KW - MUTYH-associated polyposis SP - 1067 EP - 80 JF - The Surgical clinics of North America JO - Surg Clin North Am VL - 95 IS - 5 N2 - Colorectal cancer (CRC) is the third most common cancer and the third leading cause of cancer death in men and women in the United States. About 30% of patients with CRC report a family history of CRC. However, only 5% of CRCs arise in the setting of a well-established mendelian inherited disorder. In addition, serrated polyposis is a clinically defined syndrome with multiple serrated polyps in the colorectum and an increased CRC risk for which the genetics are unknown. This article focuses on genetic and clinical aspects of Lynch syndrome, familial adenomatous polyposis, and MUTYH-associated polyposis. SN - 1558-3171 UR - https://www.unboundmedicine.com/medline/citation/26315524/Hereditary_Colorectal_Cancer:_Genetics_and_Screening_ DB - PRIME DP - Unbound Medicine ER -