Abstract
OBJECT
Posterior odontoid process inclination has been demonstrated as a factor associated with Chiari malformation Type I (CM-I) in the pediatric population; however, no studies to date have examined this measurement in the adult CM-I population. The purpose of this study was to evaluate craniocervical junction (CCJ) measurements in adult CM-I versus a control group.
METHODS
The odontoid retroflexion, odontoid retroversion, odontoid height, posterior basion to C-2 line measured to the dural margin (pB-C2 line), posterior basion to C-2 line measured to the dorsal odontoid cortical margin (pB-C2* line), and clivus-canal angle measurements were retrospectively analyzed in adult patients with CM-I using MRI. These measurements were compared with normative values established from CT scans of the cervical spine in adults without CM-I.
RESULTS
A statistically significant difference was found between 55 adults with CM-I and 150 sex-matched controls (125 used for analysis) in the mean clivus-canal angle and the mean pB-C2 line.
CONCLUSIONS
These data suggest that there are sex-specific differences with respect to measurements at the CCJ between men and women, with women showing a more posteriorly inclined odontoid process. There were also differences between the CM-I and control groups: a more acute clivus-canal angle was associated with CM-I in the adult population. These CCJ findings could have an influence on presurgical planning.
TY - JOUR
T1 - Odontoid process inclination in normal adults and in an adult population with Chiari malformation Type I.
AU - Besachio,David A,
AU - Khaleel,Ziyad,
AU - Shah,Lubdha M,
Y1 - 2015/08/28/
PY - 2015/8/29/entrez
PY - 2015/9/1/pubmed
PY - 2016/4/8/medline
KW - CCJ = craniocervical junction
KW - CM = Chiari malformation
KW - CM-I = CM Type I
KW - Chiari malformation
KW - ICC = intraclass correlation coefficient
KW - cervical
KW - complex Chiari malformation
KW - craniocervical junction
KW - odontoid inclination
KW - pB-C2 = a line drawn through the odontoid tip from the ventral dura perpendicular to a second line from the basion to the inferoposterior aspect of the C-2 vertebral body
KW - pB-C2* = a line drawn through the odontoid tip from the posterior odontoid cortex perpendicular to a second line from the basion to the inferoposterior aspect of the C-2 vertebral body
SP - 701
EP - 6
JF - Journal of neurosurgery. Spine
JO - J Neurosurg Spine
VL - 23
IS - 6
N2 - OBJECT: Posterior odontoid process inclination has been demonstrated as a factor associated with Chiari malformation Type I (CM-I) in the pediatric population; however, no studies to date have examined this measurement in the adult CM-I population. The purpose of this study was to evaluate craniocervical junction (CCJ) measurements in adult CM-I versus a control group. METHODS: The odontoid retroflexion, odontoid retroversion, odontoid height, posterior basion to C-2 line measured to the dural margin (pB-C2 line), posterior basion to C-2 line measured to the dorsal odontoid cortical margin (pB-C2* line), and clivus-canal angle measurements were retrospectively analyzed in adult patients with CM-I using MRI. These measurements were compared with normative values established from CT scans of the cervical spine in adults without CM-I. RESULTS: A statistically significant difference was found between 55 adults with CM-I and 150 sex-matched controls (125 used for analysis) in the mean clivus-canal angle and the mean pB-C2 line. CONCLUSIONS: These data suggest that there are sex-specific differences with respect to measurements at the CCJ between men and women, with women showing a more posteriorly inclined odontoid process. There were also differences between the CM-I and control groups: a more acute clivus-canal angle was associated with CM-I in the adult population. These CCJ findings could have an influence on presurgical planning.
SN - 1547-5646
UR - https://www.unboundmedicine.com/medline/citation/26315958/Odontoid_process_inclination_in_normal_adults_and_in_an_adult_population_with_Chiari_malformation_Type_I_
DB - PRIME
DP - Unbound Medicine
ER -