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Juvenile Idiopathic Arthritis in Olmsted County, Minnesota, 1960-2013.
Arthritis Rheumatol. 2016 Jan; 68(1):247-54.AR

Abstract

OBJECTIVE

To evaluate the incidence and prevalence of juvenile idiopathic arthritis (JIA) in Olmsted County, Minnesota in 1994-2013 and trends in juvenile rheumatoid arthritis (JRA) in 1960-2013.

METHODS

Cases of arthritis in 1994-2013 were identified by diagnosis code with medical chart review to confirm diagnosis separately for JIA and JRA. Overall incidence rates with 95% confidence intervals (95% CIs) were age and sex adjusted to the 2010 US white population. Comparisons were made with an earlier (1960-1993) cohort from this same population.

RESULTS

Seventy-one incident cases of JIA in 1994-2013 were identified, with an overall age- and sex-adjusted incidence rate of 10.3 per 100,000 (95% CI 7.9-12.7). Forty-two (59%) were female, with an incidence of 12.4 per 100,000 (95% CI 8.6-16.2), as compared to 8.3 per 100,000 (95% CI 5.2-11.3) in males. The most common subtype was oligoarthritis (63%). The mean ± SD age at diagnosis was 8.2 ± 5.3 years. The prevalence of JIA on January 1, 2000 and January 1, 2010 was 51.0 per 100,000 (95% CI 25.2-76.8) and 57.6 per 100,000 (95% CI 31.0-94.5), respectively. When the annual incidence of JRA was compared over time from 1960 to 2013, there was no significant change in incidence overall; however, the incidence decreased among females (P = 0.003). A cyclic pattern of incidence was observed, with peaks approximately every 10 years. Similar to the findings with regard to incidence, prevalence did not change overall, but decreased among females (P = 0.048). There were 4 deaths in the cohort of JRA patients diagnosed in 1960-2013; the standardized mortality ratio was 1.50 (95% CI 0.41-3.83).

CONCLUSION

Incidence of juvenile arthritis overall in Olmsted County, Minnesota has not changed significantly in the past 53 years. A consistent cyclic pattern was noted.

Authors+Show Affiliations

Mayo Clinic College of Medicine, Rochester, Minnesota.Mayo Clinic College of Medicine, Rochester, Minnesota.Mayo Clinic College of Medicine, Rochester, Minnesota.Mayo Clinic College of Medicine, Rochester, Minnesota.Mayo Clinic College of Medicine, Rochester, Minnesota.Mayo Clinic College of Medicine, Rochester, Minnesota.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26316119

Citation

Krause, Megan L., et al. "Juvenile Idiopathic Arthritis in Olmsted County, Minnesota, 1960-2013." Arthritis & Rheumatology (Hoboken, N.J.), vol. 68, no. 1, 2016, pp. 247-54.
Krause ML, Crowson CS, Michet CJ, et al. Juvenile Idiopathic Arthritis in Olmsted County, Minnesota, 1960-2013. Arthritis Rheumatol. 2016;68(1):247-54.
Krause, M. L., Crowson, C. S., Michet, C. J., Mason, T., Muskardin, T. W., & Matteson, E. L. (2016). Juvenile Idiopathic Arthritis in Olmsted County, Minnesota, 1960-2013. Arthritis & Rheumatology (Hoboken, N.J.), 68(1), 247-54. https://doi.org/10.1002/art.39323
Krause ML, et al. Juvenile Idiopathic Arthritis in Olmsted County, Minnesota, 1960-2013. Arthritis Rheumatol. 2016;68(1):247-54. PubMed PMID: 26316119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Juvenile Idiopathic Arthritis in Olmsted County, Minnesota, 1960-2013. AU - Krause,Megan L, AU - Crowson,Cynthia S, AU - Michet,C John, AU - Mason,Thomas, AU - Muskardin,Theresa Wampler, AU - Matteson,Eric L, PY - 2015/05/18/received PY - 2015/08/06/accepted PY - 2015/8/29/entrez PY - 2015/9/1/pubmed PY - 2016/5/4/medline SP - 247 EP - 54 JF - Arthritis & rheumatology (Hoboken, N.J.) JO - Arthritis Rheumatol VL - 68 IS - 1 N2 - OBJECTIVE: To evaluate the incidence and prevalence of juvenile idiopathic arthritis (JIA) in Olmsted County, Minnesota in 1994-2013 and trends in juvenile rheumatoid arthritis (JRA) in 1960-2013. METHODS: Cases of arthritis in 1994-2013 were identified by diagnosis code with medical chart review to confirm diagnosis separately for JIA and JRA. Overall incidence rates with 95% confidence intervals (95% CIs) were age and sex adjusted to the 2010 US white population. Comparisons were made with an earlier (1960-1993) cohort from this same population. RESULTS: Seventy-one incident cases of JIA in 1994-2013 were identified, with an overall age- and sex-adjusted incidence rate of 10.3 per 100,000 (95% CI 7.9-12.7). Forty-two (59%) were female, with an incidence of 12.4 per 100,000 (95% CI 8.6-16.2), as compared to 8.3 per 100,000 (95% CI 5.2-11.3) in males. The most common subtype was oligoarthritis (63%). The mean ± SD age at diagnosis was 8.2 ± 5.3 years. The prevalence of JIA on January 1, 2000 and January 1, 2010 was 51.0 per 100,000 (95% CI 25.2-76.8) and 57.6 per 100,000 (95% CI 31.0-94.5), respectively. When the annual incidence of JRA was compared over time from 1960 to 2013, there was no significant change in incidence overall; however, the incidence decreased among females (P = 0.003). A cyclic pattern of incidence was observed, with peaks approximately every 10 years. Similar to the findings with regard to incidence, prevalence did not change overall, but decreased among females (P = 0.048). There were 4 deaths in the cohort of JRA patients diagnosed in 1960-2013; the standardized mortality ratio was 1.50 (95% CI 0.41-3.83). CONCLUSION: Incidence of juvenile arthritis overall in Olmsted County, Minnesota has not changed significantly in the past 53 years. A consistent cyclic pattern was noted. SN - 2326-5205 UR - https://www.unboundmedicine.com/medline/citation/26316119/Juvenile_Idiopathic_Arthritis_in_Olmsted_County_Minnesota_1960_2013_ L2 - https://doi.org/10.1002/art.39323 DB - PRIME DP - Unbound Medicine ER -