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Vitamin D Deficiency and Hashimoto's Thyroiditis in Children and Adolescents: a Critical Vitamin D Level for This Association?
J Clin Res Pediatr Endocrinol. 2015 Jun; 7(2):128-33.JC

Abstract

OBJECTIVE

Vitamin D has been suggested to be active as an immunomodulator in autoimmune diseases such as Hashimoto's thyroiditis (HT). The goal of the present study was to investigate the vitamin D status in HT patients.

METHODS

This prevalence case-control study was conducted on 90 patients with HT (of ages 12.32 ± 2.87 years) and 79 age-matched healthy controls (11.85 ± 2.28 years). Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were measured in all 169 subjects.

RESULTS

The prevalence of vitamin D deficiency in HT patients (64 of 90; 71.1%) was significantly higher than that in the control group (41 of 79; 51.9%) (p=0.025). Mean serum 25(OH)D3 level in the HT group was significantly lower compared to the control group (16.67 ± 11.65 vs. 20.99 ± 9.86 ng/mL, p=0.001). HT was observed 2.28 times more frequently in individuals with 25(OH)D3 levels <20 ng/mL (OR: 2.28, CI: 1.21-4.3).

CONCLUSION

Vitamin D deficiency is associated with HT in children and adolescents. Levels lower than 20 ng/mL seem to be critical. The mechanism for this association is not clear.

Authors+Show Affiliations

İstanbul University Cerrahpaşa Faculty of Medicine, Department of Pediatric Endocrinology, İstanbul, Turkey Phone: +90 533 633 15 64 E-mail: olcayevliyaoglu@hotmail.com.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26316435

Citation

Evliyaoğlu, Olcay, et al. "Vitamin D Deficiency and Hashimoto's Thyroiditis in Children and Adolescents: a Critical Vitamin D Level for This Association?" Journal of Clinical Research in Pediatric Endocrinology, vol. 7, no. 2, 2015, pp. 128-33.
Evliyaoğlu O, Acar M, Özcabı B, et al. Vitamin D Deficiency and Hashimoto's Thyroiditis in Children and Adolescents: a Critical Vitamin D Level for This Association? J Clin Res Pediatr Endocrinol. 2015;7(2):128-33.
Evliyaoğlu, O., Acar, M., Özcabı, B., Erginöz, E., Bucak, F., Ercan, O., & Kucur, M. (2015). Vitamin D Deficiency and Hashimoto's Thyroiditis in Children and Adolescents: a Critical Vitamin D Level for This Association? Journal of Clinical Research in Pediatric Endocrinology, 7(2), 128-33. https://doi.org/10.4274/jcrpe.2011
Evliyaoğlu O, et al. Vitamin D Deficiency and Hashimoto's Thyroiditis in Children and Adolescents: a Critical Vitamin D Level for This Association. J Clin Res Pediatr Endocrinol. 2015;7(2):128-33. PubMed PMID: 26316435.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamin D Deficiency and Hashimoto's Thyroiditis in Children and Adolescents: a Critical Vitamin D Level for This Association? AU - Evliyaoğlu,Olcay, AU - Acar,Manolya, AU - Özcabı,Bahar, AU - Erginöz,Ethem, AU - Bucak,Feride, AU - Ercan,Oya, AU - Kucur,Mine, PY - 2015/8/29/entrez PY - 2015/9/1/pubmed PY - 2016/5/24/medline SP - 128 EP - 33 JF - Journal of clinical research in pediatric endocrinology JO - J Clin Res Pediatr Endocrinol VL - 7 IS - 2 N2 - OBJECTIVE: Vitamin D has been suggested to be active as an immunomodulator in autoimmune diseases such as Hashimoto's thyroiditis (HT). The goal of the present study was to investigate the vitamin D status in HT patients. METHODS: This prevalence case-control study was conducted on 90 patients with HT (of ages 12.32 ± 2.87 years) and 79 age-matched healthy controls (11.85 ± 2.28 years). Serum 25-hydroxyvitamin D3 [25(OH)D3] levels were measured in all 169 subjects. RESULTS: The prevalence of vitamin D deficiency in HT patients (64 of 90; 71.1%) was significantly higher than that in the control group (41 of 79; 51.9%) (p=0.025). Mean serum 25(OH)D3 level in the HT group was significantly lower compared to the control group (16.67 ± 11.65 vs. 20.99 ± 9.86 ng/mL, p=0.001). HT was observed 2.28 times more frequently in individuals with 25(OH)D3 levels <20 ng/mL (OR: 2.28, CI: 1.21-4.3). CONCLUSION: Vitamin D deficiency is associated with HT in children and adolescents. Levels lower than 20 ng/mL seem to be critical. The mechanism for this association is not clear. SN - 1308-5735 UR - https://www.unboundmedicine.com/medline/citation/26316435/Vitamin_D_Deficiency_and_Hashimoto's_Thyroiditis_in_Children_and_Adolescents:_a_Critical_Vitamin_D_Level_for_This_Association L2 - https://doi.org/10.4274/jcrpe.2011 DB - PRIME DP - Unbound Medicine ER -