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Subcutaneous adipose tissue plays a beneficial effect on subclinical atherosclerosis in young survivors of acute lymphocytic leukemia.
Vasc Health Risk Manag 2015; 11:479-88VH

Abstract

PURPOSE

The aim of this study was to evaluate the relationship between body composition, metabolic profile, adipokines, and carotid intima-media thickness (cIMT) in young survivors of childhood acute lymphocytic leukemia (ALL).

PATIENTS AND METHODS

This cross-sectional study compared 55 ALL survivors, of chronological age between 15 years and 24 years, assigned into two groups according to the exposure to cranial radiation therapy (CRT; 25 irradiated and 30 nonirradiated) with 24 leukemia-free controls, and assessed body fat mass (dual-energy X-ray absorptiometry), computed tomography scan-derived abdominal adipose tissue, lipid profile, blood pressure (BP), adipokines, and cIMT by a multiple regression analysis.

RESULTS

Treatment with CRT had an effect on all of the variables derived from the computed tomography scan: visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) (P<0.050). In a multiple linear regression model, cIMT positively correlated with exposure to CRT (P=0.029), diastolic BP (P=0.016), and leptin-to-adiponectin ratio (P=0.048), while negatively related to SAT (P=0.007).

CONCLUSION

In young survivors of childhood ALL, CRT modified the distribution of fat and played a critical role in determining cIMT. Leptin-to-adiponectin ratio, a biomarker of abdominal obesity and metabolic syndrome, and diastolic BP also influenced cIMT, a marker of subclinical atherosclerosis. Nonetheless, adiposity-associated vascular disease might be attenuated by SAT. Changes in body fat must be evaluated in this group of patients in the early course of survivorship in order to avoid premature cardiovascular disease associated with atherosclerosis. Yet, further research as regards the possible protective effect of SAT on vascular disease is warranted.

Authors+Show Affiliations

Division of Pediatric Endocrinology, Department of Pediatrics, Federal University of Sao Paulo (UNIFESP/EPM), Sao Paulo, Brazil ; Pediatric Oncology Institute - IOP/GRAACC, Federal University of Sao Paulo (UNIFESP/EPM), Sao Paulo, Brazil.Division of Pediatric Endocrinology, Department of Pediatrics, Federal University of Sao Paulo (UNIFESP/EPM), Sao Paulo, Brazil ; Pediatric Oncology Institute - IOP/GRAACC, Federal University of Sao Paulo (UNIFESP/EPM), Sao Paulo, Brazil.Pediatric Oncology Institute - IOP/GRAACC, Federal University of Sao Paulo (UNIFESP/EPM), Sao Paulo, Brazil.Private Office, Castro Monteiro, Sao Paulo, Brazil.Division of Cardiology, Federal University of Sao Paulo (UNIFESP/EPM), Brazil.Laboratory of Investigation on Metabolism and Diabetes (LIMED), Faculty of Medical Sciences, State University of Campinas (UNICAMP), Brazil.Laboratory of Investigation on Metabolism and Diabetes (LIMED), Faculty of Medical Sciences, State University of Campinas (UNICAMP), Brazil.Division of Pediatric Endocrinology, Department of Pediatrics, Faculty of Medical Sciences, State University of Campinas (UNICAMP), Brazil.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26316772

Citation

Siviero-Miachon, Adriana Aparecida, et al. "Subcutaneous Adipose Tissue Plays a Beneficial Effect On Subclinical Atherosclerosis in Young Survivors of Acute Lymphocytic Leukemia." Vascular Health and Risk Management, vol. 11, 2015, pp. 479-88.
Siviero-Miachon AA, Spinola-Castro AM, de Martino Lee ML, et al. Subcutaneous adipose tissue plays a beneficial effect on subclinical atherosclerosis in young survivors of acute lymphocytic leukemia. Vasc Health Risk Manag. 2015;11:479-88.
Siviero-Miachon, A. A., Spinola-Castro, A. M., de Martino Lee, M. L., de Castro Monteiro, C. M., de Camargo Carvalho, A. C., Calixto, A. R., ... Guerra-Junior, G. (2015). Subcutaneous adipose tissue plays a beneficial effect on subclinical atherosclerosis in young survivors of acute lymphocytic leukemia. Vascular Health and Risk Management, 11, pp. 479-88. doi:10.2147/VHRM.S86883.
Siviero-Miachon AA, et al. Subcutaneous Adipose Tissue Plays a Beneficial Effect On Subclinical Atherosclerosis in Young Survivors of Acute Lymphocytic Leukemia. Vasc Health Risk Manag. 2015;11:479-88. PubMed PMID: 26316772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Subcutaneous adipose tissue plays a beneficial effect on subclinical atherosclerosis in young survivors of acute lymphocytic leukemia. AU - Siviero-Miachon,Adriana Aparecida, AU - Spinola-Castro,Angela Maria, AU - de Martino Lee,Maria Lucia, AU - de Castro Monteiro,Carlos Manoel, AU - de Camargo Carvalho,Antonio Carlos, AU - Calixto,Antonio Ramos, AU - Geloneze,Bruno, AU - Guerra-Junior,Gil, Y1 - 2015/08/18/ PY - 2015/8/29/entrez PY - 2015/9/1/pubmed PY - 2016/5/25/medline KW - abdominal fat KW - adipokines KW - atherosclerosis KW - endothelium KW - metabolic syndrome X KW - precursor cell lymphoblastic leukemia–lymphoma/radiotherapy SP - 479 EP - 88 JF - Vascular health and risk management JO - Vasc Health Risk Manag VL - 11 N2 - PURPOSE: The aim of this study was to evaluate the relationship between body composition, metabolic profile, adipokines, and carotid intima-media thickness (cIMT) in young survivors of childhood acute lymphocytic leukemia (ALL). PATIENTS AND METHODS: This cross-sectional study compared 55 ALL survivors, of chronological age between 15 years and 24 years, assigned into two groups according to the exposure to cranial radiation therapy (CRT; 25 irradiated and 30 nonirradiated) with 24 leukemia-free controls, and assessed body fat mass (dual-energy X-ray absorptiometry), computed tomography scan-derived abdominal adipose tissue, lipid profile, blood pressure (BP), adipokines, and cIMT by a multiple regression analysis. RESULTS: Treatment with CRT had an effect on all of the variables derived from the computed tomography scan: visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) (P<0.050). In a multiple linear regression model, cIMT positively correlated with exposure to CRT (P=0.029), diastolic BP (P=0.016), and leptin-to-adiponectin ratio (P=0.048), while negatively related to SAT (P=0.007). CONCLUSION: In young survivors of childhood ALL, CRT modified the distribution of fat and played a critical role in determining cIMT. Leptin-to-adiponectin ratio, a biomarker of abdominal obesity and metabolic syndrome, and diastolic BP also influenced cIMT, a marker of subclinical atherosclerosis. Nonetheless, adiposity-associated vascular disease might be attenuated by SAT. Changes in body fat must be evaluated in this group of patients in the early course of survivorship in order to avoid premature cardiovascular disease associated with atherosclerosis. Yet, further research as regards the possible protective effect of SAT on vascular disease is warranted. SN - 1178-2048 UR - https://www.unboundmedicine.com/medline/citation/26316772/Subcutaneous_adipose_tissue_plays_a_beneficial_effect_on_subclinical_atherosclerosis_in_young_survivors_of_acute_lymphocytic_leukemia_ L2 - https://dx.doi.org/10.2147/VHRM.S86883 DB - PRIME DP - Unbound Medicine ER -