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Association between physical activity and all cancer mortality: Dose-response meta-analysis of cohort studies.

Abstract

The relationship between physical activity (PA) before cancer diagnosis and all cancer mortality among the general population is not well defined because of inconsistent results from published studies. Thus, the lack of a meta-analysis that addresses that issue prompted the current report. We conducted a literature search of PubMed and Web of Science to identify all relevant epidemiological studies published before February 28, 2015. We performed categorical and dose-response meta-analyses to evaluate and quantify the association between pre-diagnosis PA and all cancer mortality. A total of 32 prospective cohort studies involving 59,362 cancer deaths were included in this meta-analysis. The pooled relative risks (RRs) of all cancer mortality were 0.80 [95% confidence interval (CI) = 0.76-0.85)] for highest versus lowest PA group and 0.85 (95% CI = 0.82-0.88) for PA versus non/occasional PA group. Dose-response analysis showed that the increment in pre-diagnosis PA level was associated with a decreased risk of cancer death continuously. Moreover, an increment of 10 MET-h/week was related to a 7% lower risk for all cancer mortality (RR = 0.93, 95% CI = 0.91-0.95). In conclusion, the present meta-analysis provides evidence of an inverse association between pre-diagnosis PA and all cancer mortality among the general population. High-quality epidemiological studies that employ standardized PA assessments and unified definitions of PA levels should be developed in future.

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  • Authors+Show Affiliations

    ,

    Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, China.

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    Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, China.

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    Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, China.

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    Department of Science and Education, Xiamen Second Hospital, Xiamen, China.

    ,

    Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, China.

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    Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, China.

    ,

    Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, China.

    Department of Epidemiology and Health Statistics, Zhejiang University School of Public Health, Hangzhou, China.

    Source

    International journal of cancer 138:4 2016 Feb 15 pg 818-32

    MeSH

    Cohort Studies
    Humans
    Motor Activity
    Neoplasms

    Pub Type(s)

    Journal Article
    Meta-Analysis

    Language

    eng

    PubMed ID

    26317834

    Citation

    Li, Yingjun, et al. "Association Between Physical Activity and All Cancer Mortality: Dose-response Meta-analysis of Cohort Studies." International Journal of Cancer, vol. 138, no. 4, 2016, pp. 818-32.
    Li Y, Gu M, Jing F, et al. Association between physical activity and all cancer mortality: Dose-response meta-analysis of cohort studies. Int J Cancer. 2016;138(4):818-32.
    Li, Y., Gu, M., Jing, F., Cai, S., Bao, C., Wang, J., ... Chen, K. (2016). Association between physical activity and all cancer mortality: Dose-response meta-analysis of cohort studies. International Journal of Cancer, 138(4), pp. 818-32. doi:10.1002/ijc.29828.
    Li Y, et al. Association Between Physical Activity and All Cancer Mortality: Dose-response Meta-analysis of Cohort Studies. Int J Cancer. 2016 Feb 15;138(4):818-32. PubMed PMID: 26317834.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association between physical activity and all cancer mortality: Dose-response meta-analysis of cohort studies. AU - Li,Yingjun, AU - Gu,Mengjia, AU - Jing,Fangyuan, AU - Cai,Shaofang, AU - Bao,Chengzhen, AU - Wang,Jianbing, AU - Jin,Mingjuan, AU - Chen,Kun, Y1 - 2015/09/25/ PY - 2015/05/12/received PY - 2015/08/20/accepted PY - 2015/8/29/entrez PY - 2015/9/1/pubmed PY - 2016/6/1/medline KW - all cancer KW - dose-response KW - meta-analysis KW - mortality KW - pre-diagnosis physical activity SP - 818 EP - 32 JF - International journal of cancer JO - Int. J. Cancer VL - 138 IS - 4 N2 - The relationship between physical activity (PA) before cancer diagnosis and all cancer mortality among the general population is not well defined because of inconsistent results from published studies. Thus, the lack of a meta-analysis that addresses that issue prompted the current report. We conducted a literature search of PubMed and Web of Science to identify all relevant epidemiological studies published before February 28, 2015. We performed categorical and dose-response meta-analyses to evaluate and quantify the association between pre-diagnosis PA and all cancer mortality. A total of 32 prospective cohort studies involving 59,362 cancer deaths were included in this meta-analysis. The pooled relative risks (RRs) of all cancer mortality were 0.80 [95% confidence interval (CI) = 0.76-0.85)] for highest versus lowest PA group and 0.85 (95% CI = 0.82-0.88) for PA versus non/occasional PA group. Dose-response analysis showed that the increment in pre-diagnosis PA level was associated with a decreased risk of cancer death continuously. Moreover, an increment of 10 MET-h/week was related to a 7% lower risk for all cancer mortality (RR = 0.93, 95% CI = 0.91-0.95). In conclusion, the present meta-analysis provides evidence of an inverse association between pre-diagnosis PA and all cancer mortality among the general population. High-quality epidemiological studies that employ standardized PA assessments and unified definitions of PA levels should be developed in future. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/26317834/Association_between_physical_activity_and_all_cancer_mortality:_Dose_response_meta_analysis_of_cohort_studies_ L2 - https://doi.org/10.1002/ijc.29828 DB - PRIME DP - Unbound Medicine ER -