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Maternal supplementation with conjugated linoleic acid in the setting of diet-induced obesity normalises the inflammatory phenotype in mothers and reverses metabolic dysfunction and impaired insulin sensitivity in offspring.
J Nutr Biochem 2015; 26(12):1448-57JN

Abstract

Maternal consumption of a high-fat diet significantly impacts the fetal environment and predisposes offspring to obesity and metabolic dysfunction during adulthood. We examined the effects of a high-fat diet during pregnancy and lactation on metabolic and inflammatory profiles and whether maternal supplementation with the anti-inflammatory lipid conjugated linoleic acid (CLA) could have beneficial effects on mothers and offspring. Sprague-Dawley rats were fed a control (CD; 10% kcal from fat), CLA (CLA; 10% kcal from fat, 1% total fat as CLA), high-fat (HF; 45% kcal from fat) or high fat with CLA (HFCLA; 45% kcal from fat, 1% total fat as CLA) diet ad libitum 10days prior to and throughout gestation and lactation. Dams and offspring were culled at either late gestation (fetal day 20, F20) or early postweaning (postnatal day 24, P24). CLA, HF and HFCLA dams were heavier than CD throughout gestation. Plasma concentrations of proinflammatory cytokines interleukin-1β and tumour necrosis factor-α were elevated in HF dams, with restoration in HFCLA dams. Male and female fetuses from HF dams were smaller at F20 but displayed catch-up growth and impaired insulin sensitivity at P24, which was reversed in HFCLA offspring. HFCLA dams at P24 were protected from impaired insulin sensitivity as compared to HF dams. Maternal CLA supplementation normalised inflammation associated with consumption of a high-fat diet and reversed associated programming of metabolic dysfunction in offspring. This demonstrates that there are critical windows of developmental plasticity in which the effects of an adverse early-life environment can be reversed by maternal dietary interventions.

Authors+Show Affiliations

Liggins Institute and Gravida, National Centre for Growth and Development, University of Auckland, Auckland 1023, New Zealand.Liggins Institute and Gravida, National Centre for Growth and Development, University of Auckland, Auckland 1023, New Zealand.Liggins Institute and Gravida, National Centre for Growth and Development, University of Auckland, Auckland 1023, New Zealand.Liggins Institute and Gravida, National Centre for Growth and Development, University of Auckland, Auckland 1023, New Zealand.Liggins Institute and Gravida, National Centre for Growth and Development, University of Auckland, Auckland 1023, New Zealand. Electronic address: c.reynolds@auckland.ac.nz.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26318151

Citation

Segovia, Stephanie A., et al. "Maternal Supplementation With Conjugated Linoleic Acid in the Setting of Diet-induced Obesity Normalises the Inflammatory Phenotype in Mothers and Reverses Metabolic Dysfunction and Impaired Insulin Sensitivity in Offspring." The Journal of Nutritional Biochemistry, vol. 26, no. 12, 2015, pp. 1448-57.
Segovia SA, Vickers MH, Zhang XD, et al. Maternal supplementation with conjugated linoleic acid in the setting of diet-induced obesity normalises the inflammatory phenotype in mothers and reverses metabolic dysfunction and impaired insulin sensitivity in offspring. J Nutr Biochem. 2015;26(12):1448-57.
Segovia, S. A., Vickers, M. H., Zhang, X. D., Gray, C., & Reynolds, C. M. (2015). Maternal supplementation with conjugated linoleic acid in the setting of diet-induced obesity normalises the inflammatory phenotype in mothers and reverses metabolic dysfunction and impaired insulin sensitivity in offspring. The Journal of Nutritional Biochemistry, 26(12), pp. 1448-57. doi:10.1016/j.jnutbio.2015.07.013.
Segovia SA, et al. Maternal Supplementation With Conjugated Linoleic Acid in the Setting of Diet-induced Obesity Normalises the Inflammatory Phenotype in Mothers and Reverses Metabolic Dysfunction and Impaired Insulin Sensitivity in Offspring. J Nutr Biochem. 2015;26(12):1448-57. PubMed PMID: 26318151.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Maternal supplementation with conjugated linoleic acid in the setting of diet-induced obesity normalises the inflammatory phenotype in mothers and reverses metabolic dysfunction and impaired insulin sensitivity in offspring. AU - Segovia,Stephanie A, AU - Vickers,Mark H, AU - Zhang,Xiaoyuan D, AU - Gray,Clint, AU - Reynolds,Clare M, Y1 - 2015/08/01/ PY - 2014/12/04/received PY - 2015/06/25/revised PY - 2015/07/18/accepted PY - 2015/8/31/entrez PY - 2015/9/1/pubmed PY - 2016/12/15/medline KW - Conjugated linoleic acid KW - Developmental programming KW - Impaired insulin sensitivity KW - Inflammation KW - Maternal obesity SP - 1448 EP - 57 JF - The Journal of nutritional biochemistry JO - J. Nutr. Biochem. VL - 26 IS - 12 N2 - Maternal consumption of a high-fat diet significantly impacts the fetal environment and predisposes offspring to obesity and metabolic dysfunction during adulthood. We examined the effects of a high-fat diet during pregnancy and lactation on metabolic and inflammatory profiles and whether maternal supplementation with the anti-inflammatory lipid conjugated linoleic acid (CLA) could have beneficial effects on mothers and offspring. Sprague-Dawley rats were fed a control (CD; 10% kcal from fat), CLA (CLA; 10% kcal from fat, 1% total fat as CLA), high-fat (HF; 45% kcal from fat) or high fat with CLA (HFCLA; 45% kcal from fat, 1% total fat as CLA) diet ad libitum 10days prior to and throughout gestation and lactation. Dams and offspring were culled at either late gestation (fetal day 20, F20) or early postweaning (postnatal day 24, P24). CLA, HF and HFCLA dams were heavier than CD throughout gestation. Plasma concentrations of proinflammatory cytokines interleukin-1β and tumour necrosis factor-α were elevated in HF dams, with restoration in HFCLA dams. Male and female fetuses from HF dams were smaller at F20 but displayed catch-up growth and impaired insulin sensitivity at P24, which was reversed in HFCLA offspring. HFCLA dams at P24 were protected from impaired insulin sensitivity as compared to HF dams. Maternal CLA supplementation normalised inflammation associated with consumption of a high-fat diet and reversed associated programming of metabolic dysfunction in offspring. This demonstrates that there are critical windows of developmental plasticity in which the effects of an adverse early-life environment can be reversed by maternal dietary interventions. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/26318151/Maternal_supplementation_with_conjugated_linoleic_acid_in_the_setting_of_diet_induced_obesity_normalises_the_inflammatory_phenotype_in_mothers_and_reverses_metabolic_dysfunction_and_impaired_insulin_sensitivity_in_offspring_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(15)00177-1 DB - PRIME DP - Unbound Medicine ER -