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Serum ferritin is associated with carotid atherosclerotic plaques but not intima-media Thickness in patients with abnormal glucose metabolism.
Clin Chim Acta 2015; 450:190-5CC

Abstract

BACKGROUND

We investigated the association between serum ferritin and carotid artery lesions in populations with abnormal glucose metabolism.

METHODS

We included 70 participants with abnormal glucose metabolism and 170 participants with normal glucose metabolism and measured their baseline serum ferritin levels. During follow-up carotid intima-media thickness and carotid plaque were evaluated.

RESULTS

Serum ferritin levels were higher in the participants with abnormal glucose metabolism (p<0.01). We further divided the patients with abnormal glucose metabolism into subgroups with and without intima-media proliferation, and found that ferritin was excluded from the final equation in the logistic regression. Furthermore, age, waist circumference, ferritin, 2h-PG, and total cholesterol were significantly different between the subgroups with and without carotid plaque. When the above data were included in a logistic regression model, the p values obtained for age, ferritin, and 2h-PG were 0.004, 0.032, and 0.011, respectively.

CONCLUSIONS

In the Chinese population, serum ferritin levels are significantly increased in patients with abnormal glucose metabolism. The carotid intima-media thickness showed no independent relationship with serum ferritin in patients with abnormal glucose metabolism. However, high serum ferritin is an important risk factor for carotid atherosclerosis in these patients.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.Laboratory of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China.First People's Hospital of Longquanyi District, Chengdu 610041, Sichuan, People's Republic of China.Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, People's Republic of China. Electronic address: hmtian666@163.com.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26319885

Citation

Zhou, F L., et al. "Serum Ferritin Is Associated With Carotid Atherosclerotic Plaques but Not Intima-media Thickness in Patients With Abnormal Glucose Metabolism." Clinica Chimica Acta; International Journal of Clinical Chemistry, vol. 450, 2015, pp. 190-5.
Zhou FL, Gao Y, Tian L, et al. Serum ferritin is associated with carotid atherosclerotic plaques but not intima-media Thickness in patients with abnormal glucose metabolism. Clin Chim Acta. 2015;450:190-5.
Zhou, F. L., Gao, Y., Tian, L., Yan, F. F., Chen, T., Zhong, L., & Tian, H. M. (2015). Serum ferritin is associated with carotid atherosclerotic plaques but not intima-media Thickness in patients with abnormal glucose metabolism. Clinica Chimica Acta; International Journal of Clinical Chemistry, 450, pp. 190-5. doi:10.1016/j.cca.2015.08.024.
Zhou FL, et al. Serum Ferritin Is Associated With Carotid Atherosclerotic Plaques but Not Intima-media Thickness in Patients With Abnormal Glucose Metabolism. Clin Chim Acta. 2015 Oct 23;450:190-5. PubMed PMID: 26319885.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum ferritin is associated with carotid atherosclerotic plaques but not intima-media Thickness in patients with abnormal glucose metabolism. AU - Zhou,F L, AU - Gao,Y, AU - Tian,L, AU - Yan,F F, AU - Chen,T, AU - Zhong,L, AU - Tian,H M, Y1 - 2015/08/28/ PY - 2015/06/03/received PY - 2015/08/06/revised PY - 2015/08/25/accepted PY - 2015/8/31/entrez PY - 2015/9/1/pubmed PY - 2016/4/26/medline KW - Carotid atherosclerosis KW - Glucose metabolism KW - Intima-media thickness KW - Serum ferritin SP - 190 EP - 5 JF - Clinica chimica acta; international journal of clinical chemistry JO - Clin. Chim. Acta VL - 450 N2 - BACKGROUND: We investigated the association between serum ferritin and carotid artery lesions in populations with abnormal glucose metabolism. METHODS: We included 70 participants with abnormal glucose metabolism and 170 participants with normal glucose metabolism and measured their baseline serum ferritin levels. During follow-up carotid intima-media thickness and carotid plaque were evaluated. RESULTS: Serum ferritin levels were higher in the participants with abnormal glucose metabolism (p<0.01). We further divided the patients with abnormal glucose metabolism into subgroups with and without intima-media proliferation, and found that ferritin was excluded from the final equation in the logistic regression. Furthermore, age, waist circumference, ferritin, 2h-PG, and total cholesterol were significantly different between the subgroups with and without carotid plaque. When the above data were included in a logistic regression model, the p values obtained for age, ferritin, and 2h-PG were 0.004, 0.032, and 0.011, respectively. CONCLUSIONS: In the Chinese population, serum ferritin levels are significantly increased in patients with abnormal glucose metabolism. The carotid intima-media thickness showed no independent relationship with serum ferritin in patients with abnormal glucose metabolism. However, high serum ferritin is an important risk factor for carotid atherosclerosis in these patients. SN - 1873-3492 UR - https://www.unboundmedicine.com/medline/citation/26319885/Serum_ferritin_is_associated_with_carotid_atherosclerotic_plaques_but_not_intima_media_Thickness_in_patients_with_abnormal_glucose_metabolism_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-8981(15)00404-0 DB - PRIME DP - Unbound Medicine ER -