Fasting Blood Glucose and Insulin Level in Opium Addict versus Non-Addict Individuals.
Addict Health. 2015 Winter-Spring; 7(1-2):54-9.AH

Abstract

BACKGROUND

Many of lay person believe that opium lowers blood glucose. However some studies show the opposite results. In this study, we tried to evaluate the effect of opium on blood glucose and insulin resistance.

METHODS

This comparative study including 53 addicts in case groups who used opium just in the form of smoking and 55 non-addicts in a control group, took part in the study, after proving not to be opium users. After taking blood samples, their fasting blood glucose (FBG), fasting blood insulin and lipid profiles were evaluated. Furthermore, insulin resistance index was analyzed via the homeostatic model assessment of insulin resistance (HOMA-IR) formula with the cut-off points of 7.2 and 7.1.

FINDINGS

Age and gender were not significantly different between the groups. There was no significant difference regarding the prevalence of insulin resistance between the two groups, according to the cut-off points of 7.1 and 7.2 (P = 0.196 and P = 0.248, respectively). Mean insulin resistance index was not significantly different between the two groups (P = 0.325). In the case group, fasting blood insulin was considerably lower (P = 0.025) and fasting blood sugar (FBS) was significantly higher (P = 0.016) than the control group.

CONCLUSION

According to the level of insulin and FBS in addicts, it does not seem that opium has a significant effect on reducing the blood glucose and insulin resistance.

Links

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Authors+Show Affiliations

Gozashti MH

Associate Professor, Endocrinologist, Neuroscience Research Center, Kerman University of Medical Sciences, Kerman, Iran.

Yazdi F

Assistant Professor, Department of Internal Medicine, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Salajegheh P

Fellowship of Hemato Oncology, Department of Pediatrics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.

Dehesh MM

Student of Medicine, Student Research Committee, School of Medicine, Kerman University of Medical Sciences, Kerman, Iran.

Divsalar K

Researcher, Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26322211

Citation

Gozashti, Mohammad Hossein, et al. "Fasting Blood Glucose and Insulin Level in Opium Addict Versus Non-Addict Individuals." Addiction & Health, vol. 7, no. 1-2, 2015, pp. 54-9.

Gozashti MH, Yazdi F, Salajegheh P, et al. Fasting Blood Glucose and Insulin Level in Opium Addict versus Non-Addict Individuals. Addict Health. 2015;7(1-2):54-9.

Gozashti, M. H., Yazdi, F., Salajegheh, P., Dehesh, M. M., & Divsalar, K. (2015). Fasting Blood Glucose and Insulin Level in Opium Addict versus Non-Addict Individuals. Addiction & Health, 7(1-2), 54-9.

Gozashti MH, et al. Fasting Blood Glucose and Insulin Level in Opium Addict Versus Non-Addict Individuals. Addict Health. 2015 Winter-Spring;7(1-2):54-9. PubMed PMID: 26322211.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - Fasting Blood Glucose and Insulin Level in Opium Addict versus Non-Addict Individuals. AU - Gozashti,Mohammad Hossein, AU - Yazdi,Farzaneh, AU - Salajegheh,Pouria, AU - Dehesh,Mohammad Moein, AU - Divsalar,Kouros, PY - 2014/10/03/received PY - 2014/12/19/accepted PY - 2015/9/1/entrez PY - 2015/9/1/pubmed PY - 2015/9/1/medline KW - Blood sugar KW - Insulin resistance KW - Opium addiction SP - 54 EP - 9 JF - Addiction & health JO - Addict Health VL - 7 IS - 1-2 N2 - BACKGROUND: Many of lay person believe that opium lowers blood glucose. However some studies show the opposite results. In this study, we tried to evaluate the effect of opium on blood glucose and insulin resistance. METHODS: This comparative study including 53 addicts in case groups who used opium just in the form of smoking and 55 non-addicts in a control group, took part in the study, after proving not to be opium users. After taking blood samples, their fasting blood glucose (FBG), fasting blood insulin and lipid profiles were evaluated. Furthermore, insulin resistance index was analyzed via the homeostatic model assessment of insulin resistance (HOMA-IR) formula with the cut-off points of 7.2 and 7.1. FINDINGS: Age and gender were not significantly different between the groups. There was no significant difference regarding the prevalence of insulin resistance between the two groups, according to the cut-off points of 7.1 and 7.2 (P = 0.196 and P = 0.248, respectively). Mean insulin resistance index was not significantly different between the two groups (P = 0.325). In the case group, fasting blood insulin was considerably lower (P = 0.025) and fasting blood sugar (FBS) was significantly higher (P = 0.016) than the control group. CONCLUSION: According to the level of insulin and FBS in addicts, it does not seem that opium has a significant effect on reducing the blood glucose and insulin resistance. SN - 2008-4633 UR - https://www.unboundmedicine.com/medline/citation/26322211/Fasting_Blood_Glucose_and_Insulin_Level_in_Opium_Addict_versus_Non_Addict_Individuals_ DB - PRIME DP - Unbound Medicine ER -

Tags

Fasting Blood Glucose and Insulin Level in Opium Addict versus Non-Addict Individuals.Addict Health. 2015 Winter-Spring; 7(1-2):54-9.AH