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Long-term contraception in a small implant: A review of Suprelorin (deslorelin) studies in cats.
J Feline Med Surg 2015; 17(9):766-71JF

Abstract

RATIONALE

Deslorelin (Suprelorin®; Virbac) is a gonadotropin-releasing hormone (GnRH) agonist licensed in select countries for the long-term suppression of fertility in adult male dogs and male ferrets. This article summarizes studies investigating the use of deslorelin implants for the long-term suppression of fertility in male and female domestic cats.

EVIDENCE BASE

Slow-release deslorelin implants have been shown to generate effective, safe and reversible long-term contraception in male and female cats. In pubertal cats, a 4.7 mg deslorelin implant suppressed steroid sex hormones for an average of approximately 20 months (range 15-25 months) in males and an average of approximately 24 months (range 16-37 months) in females. Reversibility has been demonstrated by fertile matings approximately 2 years post-treatment in both male and female adult cats. In prepubertal female cats of approximately 4 months of age, puberty was postponed to an average of approximately 10 months of age (range 6-15 months) by a 4.7 mg deslorelin implant.

CHALLENGES

The large variability in the duration of suppression of gonadal activity makes the definition of the optimal time for reimplantation quite challenging. In addition, the temporary stimulation phase occurring in the weeks following deslorelin implantation can induce in adult female cats a fertile estrus that needs to be managed to avoid unwanted pregnancy. Longer duration and larger scale controlled field studies implementing blinding, a negative control group and a carefully controlled randomization to each group are needed. Furthermore, the effects of repeated treatment need to be investigated. Finally, the effect of treatment on growth and bone quality of prepubertal cats needs to be assessed. However, the ease of use, long-lasting effects and reversibility of deslorelin implants are strong positive points supporting their use for controlling feline reproduction.

Authors+Show Affiliations

Medical Manager - Companion Animal Medical Department, Virbac, France christelle.fontaine@virbac.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26323800

Citation

Fontaine, Christelle. "Long-term Contraception in a Small Implant: a Review of Suprelorin (deslorelin) Studies in Cats." Journal of Feline Medicine and Surgery, vol. 17, no. 9, 2015, pp. 766-71.
Fontaine C. Long-term contraception in a small implant: A review of Suprelorin (deslorelin) studies in cats. J Feline Med Surg. 2015;17(9):766-71.
Fontaine, C. (2015). Long-term contraception in a small implant: A review of Suprelorin (deslorelin) studies in cats. Journal of Feline Medicine and Surgery, 17(9), pp. 766-71. doi:10.1177/1098612X15594990.
Fontaine C. Long-term Contraception in a Small Implant: a Review of Suprelorin (deslorelin) Studies in Cats. J Feline Med Surg. 2015;17(9):766-71. PubMed PMID: 26323800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term contraception in a small implant: A review of Suprelorin (deslorelin) studies in cats. A1 - Fontaine,Christelle, PY - 2015/9/2/entrez PY - 2015/9/2/pubmed PY - 2016/4/7/medline SP - 766 EP - 71 JF - Journal of feline medicine and surgery JO - J. Feline Med. Surg. VL - 17 IS - 9 N2 - RATIONALE: Deslorelin (Suprelorin®; Virbac) is a gonadotropin-releasing hormone (GnRH) agonist licensed in select countries for the long-term suppression of fertility in adult male dogs and male ferrets. This article summarizes studies investigating the use of deslorelin implants for the long-term suppression of fertility in male and female domestic cats. EVIDENCE BASE: Slow-release deslorelin implants have been shown to generate effective, safe and reversible long-term contraception in male and female cats. In pubertal cats, a 4.7 mg deslorelin implant suppressed steroid sex hormones for an average of approximately 20 months (range 15-25 months) in males and an average of approximately 24 months (range 16-37 months) in females. Reversibility has been demonstrated by fertile matings approximately 2 years post-treatment in both male and female adult cats. In prepubertal female cats of approximately 4 months of age, puberty was postponed to an average of approximately 10 months of age (range 6-15 months) by a 4.7 mg deslorelin implant. CHALLENGES: The large variability in the duration of suppression of gonadal activity makes the definition of the optimal time for reimplantation quite challenging. In addition, the temporary stimulation phase occurring in the weeks following deslorelin implantation can induce in adult female cats a fertile estrus that needs to be managed to avoid unwanted pregnancy. Longer duration and larger scale controlled field studies implementing blinding, a negative control group and a carefully controlled randomization to each group are needed. Furthermore, the effects of repeated treatment need to be investigated. Finally, the effect of treatment on growth and bone quality of prepubertal cats needs to be assessed. However, the ease of use, long-lasting effects and reversibility of deslorelin implants are strong positive points supporting their use for controlling feline reproduction. SN - 1532-2750 UR - https://www.unboundmedicine.com/medline/citation/26323800/Long_term_contraception_in_a_small_implant:_A_review_of_Suprelorin__deslorelin__studies_in_cats_ L2 - http://journals.sagepub.com/doi/full/10.1177/1098612X15594990?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -