Tags

Type your tag names separated by a space and hit enter

Trends and Disparities in Cardiovascular Mortality Among Survivors of Hodgkin Lymphoma.
Clin Lymphoma Myeloma Leuk 2015; 15(12):748-52CL

Abstract

BACKGROUND

Over the past decades, survival of patients with Hodgkin lymphoma (HL) has increased but remains curtailed by cardiovascular mortality (CVM). HL survivors at greatest risk for cardiovascular death have not been clearly identified. We sought to report trends of CVM identify HL survivors at highest risk.

METHODS

The Surveillance, Epidemiology, and End Results (SEER) database was queried for all adult patients diagnosed with HL (age 20-49 years) between 1990 and 2011. The trend of CVM and disparities are presented.

RESULTS

Of 19,781 HL patients, 53% were male and 83% were white; patients had a mean age of 33 ± 8.3 years at diagnosis. Eighteen percent had stage I disease, 45% stage II, 18% stage III, and 15% stage IV. The risk for CVM was higher in blacks (adjusted hazard ratio [HR], 1.97; P = .002), men (adjusted HR, 2.2; P < .001), and patients with older age at diagnosis (adjusted HR, 1.073 per year; P < .001). CVM has decreased, with 5-year cumulative incidence decreasing from 1.17% in 1990 to 0.18% in 2006, averaging 7% per year (adjusted HR, 0.927; P < .001). This trend was seen only in patients with early disease (P < .001) but not with advanced disease (P = NS). CVM as a proportion of all-cause mortality increases sharply at 50 years of age, constituting more than 30% of all causes of death.

CONCLUSION

Despite an overall decrease in CVM in HL survivors over the last decades, older patients, black patients, and men, especially those who have advanced-stage disease at diagnosis, are at the highest risk of cardiovascular death. Cardiovascular screening and risk modification should be intensified in HL patients with these characteristics.

Authors+Show Affiliations

Onco-cardiology program, Harrington Heart and Vascular Institute, and Seidman Cancer Center, University Hospitals, Cleveland, OH; School of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH.New York Presbyterian Hospital, Weill Cornell Medical College, New York, NY.Onco-cardiology program, Harrington Heart and Vascular Institute, and Seidman Cancer Center, University Hospitals, Cleveland, OH; School of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH.Onco-cardiology program, Harrington Heart and Vascular Institute, and Seidman Cancer Center, University Hospitals, Cleveland, OH.School of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH; University Hospitals Seidman Cancer Center, Cleveland, OH.School of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH; University Hospitals Seidman Cancer Center, Cleveland, OH.Onco-cardiology program, Harrington Heart and Vascular Institute, and Seidman Cancer Center, University Hospitals, Cleveland, OH; School of Medicine, Case Western Reserve University School of Medicine, Cleveland, OH; University Hospitals Seidman Cancer Center, Cleveland, OH. Electronic address: guilherme.oliveira@uhhospitals.org.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26324747

Citation

Al-Kindi, Sadeer G., et al. "Trends and Disparities in Cardiovascular Mortality Among Survivors of Hodgkin Lymphoma." Clinical Lymphoma, Myeloma & Leukemia, vol. 15, no. 12, 2015, pp. 748-52.
Al-Kindi SG, Abu-Zeinah GF, Kim CH, et al. Trends and Disparities in Cardiovascular Mortality Among Survivors of Hodgkin Lymphoma. Clin Lymphoma Myeloma Leuk. 2015;15(12):748-52.
Al-Kindi, S. G., Abu-Zeinah, G. F., Kim, C. H., Hejjaji, V., William, B. M., Caimi, P. F., & Oliveira, G. H. (2015). Trends and Disparities in Cardiovascular Mortality Among Survivors of Hodgkin Lymphoma. Clinical Lymphoma, Myeloma & Leukemia, 15(12), pp. 748-52. doi:10.1016/j.clml.2015.07.638.
Al-Kindi SG, et al. Trends and Disparities in Cardiovascular Mortality Among Survivors of Hodgkin Lymphoma. Clin Lymphoma Myeloma Leuk. 2015;15(12):748-52. PubMed PMID: 26324747.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Trends and Disparities in Cardiovascular Mortality Among Survivors of Hodgkin Lymphoma. AU - Al-Kindi,Sadeer G, AU - Abu-Zeinah,Ghaith F, AU - Kim,Chang H, AU - Hejjaji,Vittal, AU - William,Basem M, AU - Caimi,Paolo F, AU - Oliveira,Guilherme H, Y1 - 2015/08/05/ PY - 2015/04/29/received PY - 2015/06/28/revised PY - 2015/07/28/accepted PY - 2015/9/2/entrez PY - 2015/9/2/pubmed PY - 2016/9/9/medline KW - Cardiovascular disease KW - Hodgkin lymphoma KW - Mortality KW - Race KW - SEER SP - 748 EP - 52 JF - Clinical lymphoma, myeloma & leukemia JO - Clin Lymphoma Myeloma Leuk VL - 15 IS - 12 N2 - BACKGROUND: Over the past decades, survival of patients with Hodgkin lymphoma (HL) has increased but remains curtailed by cardiovascular mortality (CVM). HL survivors at greatest risk for cardiovascular death have not been clearly identified. We sought to report trends of CVM identify HL survivors at highest risk. METHODS: The Surveillance, Epidemiology, and End Results (SEER) database was queried for all adult patients diagnosed with HL (age 20-49 years) between 1990 and 2011. The trend of CVM and disparities are presented. RESULTS: Of 19,781 HL patients, 53% were male and 83% were white; patients had a mean age of 33 ± 8.3 years at diagnosis. Eighteen percent had stage I disease, 45% stage II, 18% stage III, and 15% stage IV. The risk for CVM was higher in blacks (adjusted hazard ratio [HR], 1.97; P = .002), men (adjusted HR, 2.2; P < .001), and patients with older age at diagnosis (adjusted HR, 1.073 per year; P < .001). CVM has decreased, with 5-year cumulative incidence decreasing from 1.17% in 1990 to 0.18% in 2006, averaging 7% per year (adjusted HR, 0.927; P < .001). This trend was seen only in patients with early disease (P < .001) but not with advanced disease (P = NS). CVM as a proportion of all-cause mortality increases sharply at 50 years of age, constituting more than 30% of all causes of death. CONCLUSION: Despite an overall decrease in CVM in HL survivors over the last decades, older patients, black patients, and men, especially those who have advanced-stage disease at diagnosis, are at the highest risk of cardiovascular death. Cardiovascular screening and risk modification should be intensified in HL patients with these characteristics. SN - 2152-2669 UR - https://www.unboundmedicine.com/medline/citation/26324747/Trends_and_Disparities_in_Cardiovascular_Mortality_Among_Survivors_of_Hodgkin_Lymphoma_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S2152-2650(15)01070-8 DB - PRIME DP - Unbound Medicine ER -