Tags

Type your tag names separated by a space and hit enter

Flavonol Intake and Cognitive Decline in Middle-Aged Adults.
J Med Food 2015; 18(12):1327-32JM

Abstract

Cognitive decline occurs with age and may be slowed by dietary measures, including increased intake of dietary phytochemicals. However, evidence from large and long-term studies of flavonol intake is limited. Dietary intakes of flavonols were assessed from a large biracial study of 10,041 subjects, aged 45-64, by analysis of a food frequency questionnaire administered at visit 1 of triennial visits. Cognitive function was assessed at visits 2 and 4 with the following three cognitive performance tests: the delayed word recall test, the revised Wechsler Adult Intelligence Scale digit symbol subtest, and the word fluency test of the Multilingual Aphasia Examination. The change in each score over 6 years was calculated, and a combined standardized change score was calculated. Generalized linear models controlled for age, ethnicity, gender, education level, energy intake, current smoking, physical activity, body mass index, diabetes, and vitamin C intake. Total flavonols across quintiles of intake were positively associated with preserved combined cognitive function (P<.001). This pattern with preserved combined cognitive function was consistent for the three major individual flavonols in the diet, myricetin, kaempferol, and quercetin (each P<.001). The positive association with total flavonols was strongest for the digit symbol subtest (P<.001). In this cohort, flavonol intake was correlated with protected cognitive function over time.

Authors+Show Affiliations

Department of Nutrition and Health Care Management, Appalachian State University , Boone, North Carolina.Department of Nutrition and Health Care Management, Appalachian State University , Boone, North Carolina.Department of Nutrition and Health Care Management, Appalachian State University , Boone, North Carolina.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26325006

Citation

Root, Martin, et al. "Flavonol Intake and Cognitive Decline in Middle-Aged Adults." Journal of Medicinal Food, vol. 18, no. 12, 2015, pp. 1327-32.
Root M, Ravine E, Harper A. Flavonol Intake and Cognitive Decline in Middle-Aged Adults. J Med Food. 2015;18(12):1327-32.
Root, M., Ravine, E., & Harper, A. (2015). Flavonol Intake and Cognitive Decline in Middle-Aged Adults. Journal of Medicinal Food, 18(12), pp. 1327-32. doi:10.1089/jmf.2015.0010.
Root M, Ravine E, Harper A. Flavonol Intake and Cognitive Decline in Middle-Aged Adults. J Med Food. 2015;18(12):1327-32. PubMed PMID: 26325006.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonol Intake and Cognitive Decline in Middle-Aged Adults. AU - Root,Martin, AU - Ravine,Erin, AU - Harper,Anne, Y1 - 2015/09/01/ PY - 2015/9/2/entrez PY - 2015/9/2/pubmed PY - 2016/9/23/medline KW - ARIC KW - cognitive function KW - dementia KW - diet KW - flavonoids KW - prospective cohort SP - 1327 EP - 32 JF - Journal of medicinal food JO - J Med Food VL - 18 IS - 12 N2 - Cognitive decline occurs with age and may be slowed by dietary measures, including increased intake of dietary phytochemicals. However, evidence from large and long-term studies of flavonol intake is limited. Dietary intakes of flavonols were assessed from a large biracial study of 10,041 subjects, aged 45-64, by analysis of a food frequency questionnaire administered at visit 1 of triennial visits. Cognitive function was assessed at visits 2 and 4 with the following three cognitive performance tests: the delayed word recall test, the revised Wechsler Adult Intelligence Scale digit symbol subtest, and the word fluency test of the Multilingual Aphasia Examination. The change in each score over 6 years was calculated, and a combined standardized change score was calculated. Generalized linear models controlled for age, ethnicity, gender, education level, energy intake, current smoking, physical activity, body mass index, diabetes, and vitamin C intake. Total flavonols across quintiles of intake were positively associated with preserved combined cognitive function (P<.001). This pattern with preserved combined cognitive function was consistent for the three major individual flavonols in the diet, myricetin, kaempferol, and quercetin (each P<.001). The positive association with total flavonols was strongest for the digit symbol subtest (P<.001). In this cohort, flavonol intake was correlated with protected cognitive function over time. SN - 1557-7600 UR - https://www.unboundmedicine.com/medline/citation/26325006/Flavonol_Intake_and_Cognitive_Decline_in_Middle_Aged_Adults_ L2 - https://www.liebertpub.com/doi/full/10.1089/jmf.2015.0010?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -