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Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence.
Curr Pain Headache Rep 2015; 19(10):50CP

Abstract

Cannabinoid compounds include phytocannabinoids, endocannabinoids, and synthetics. The two primary phytocannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), with CB1 receptors in the brain and peripheral tissue and CB2 receptors in the immune and hematopoietic systems. The route of delivery of cannabis is important as the bioavailability and metabolism are very different for smoking versus oral/sublingual routes. Gold standard clinical trials are limited; however, some studies have thus far shown evidence to support the use of cannabinoids for some cancer, neuropathic, spasticity, acute pain, and chronic pain conditions.

Authors+Show Affiliations

Center for Pain Medicine, University of California San Diego, 9300 Campus Point Drive, Mail Code 7651, La Jolla, CA, 92037, USA, bbjensen@ucsd.edu.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26325482

Citation

Jensen, Bjorn, et al. "Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence." Current Pain and Headache Reports, vol. 19, no. 10, 2015, p. 50.
Jensen B, Chen J, Furnish T, et al. Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence. Curr Pain Headache Rep. 2015;19(10):50.
Jensen, B., Chen, J., Furnish, T., & Wallace, M. (2015). Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence. Current Pain and Headache Reports, 19(10), p. 50. doi:10.1007/s11916-015-0524-x.
Jensen B, et al. Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence. Curr Pain Headache Rep. 2015;19(10):50. PubMed PMID: 26325482.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Medical Marijuana and Chronic Pain: a Review of Basic Science and Clinical Evidence. AU - Jensen,Bjorn, AU - Chen,Jeffrey, AU - Furnish,Tim, AU - Wallace,Mark, PY - 2015/9/2/entrez PY - 2015/9/2/pubmed PY - 2016/5/11/medline SP - 50 EP - 50 JF - Current pain and headache reports JO - Curr Pain Headache Rep VL - 19 IS - 10 N2 - Cannabinoid compounds include phytocannabinoids, endocannabinoids, and synthetics. The two primary phytocannabinoids are delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD), with CB1 receptors in the brain and peripheral tissue and CB2 receptors in the immune and hematopoietic systems. The route of delivery of cannabis is important as the bioavailability and metabolism are very different for smoking versus oral/sublingual routes. Gold standard clinical trials are limited; however, some studies have thus far shown evidence to support the use of cannabinoids for some cancer, neuropathic, spasticity, acute pain, and chronic pain conditions. SN - 1534-3081 UR - https://www.unboundmedicine.com/medline/citation/26325482/Medical_Marijuana_and_Chronic_Pain:_a_Review_of_Basic_Science_and_Clinical_Evidence_ L2 - https://dx.doi.org/10.1007/s11916-015-0524-x DB - PRIME DP - Unbound Medicine ER -