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Similar eicosapentaenoic acid and docosahexaenoic acid plasma levels achieved with fish oil or krill oil in a randomized double-blind four-week bioavailability study.
Lipids Health Dis 2015; 14:99LH

Abstract

BACKGROUND

Long-chain n-3 polyunsaturated fatty acids (LC n-3-PUFA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) provide multiple health benefits for heart, brain and eyes. However, consumption of fatty fish, the main source of LC n-3-PUFAs is low in Western countries. Intakes of LC n-3-PUFA can be increased by taking dietary supplements, such as fish oil, algal oil, or krill oil. Recently, conflicting information was published on the relative bioavailability of these omega-3 supplements. A few studies suggested that the phospholipid form (krill) is better absorbed than the fish oil ethyl ester (EE) or triglyceride (TG) forms. Yet studies did not match the doses administered nor the concentrations of DHA and EPA per supplement across such comparisons, leading to questionable conclusions. This study was designed to compare the oral bioavailability of the same dose of both EPA and DHA in fish oil-EE vs. fish oil-TG vs. krill oil in plasma at the end of a four-week supplementation.

METHODS

Sixty-six healthy adults (n = 22/arm) were enrolled in a double blind, randomized, three-treatment, multi-dose, parallel study. Subjects were supplemented with a 1.3 g/d dose of EPA + DHA (approximately 816 mg/d EPA + 522 mg/d DHA, regardless of formulation) for 28 consecutive days, as either fish oil-EE, fish oil-TG or krill oil capsules (6 caps/day). Plasma and red blood cell (RBC) samples were collected at baseline (pre-dose on Day 1) and at 4, 8, 12, 48, 72, 336, and 672 h. Total plasma EPA + DHA levels at Week 4 (Hour 672) were measured as the primary endpoint.

RESULTS

No significant differences in total plasma EPA + DHA at 672 h were observed between fish oil-EE (mean = 90.9 ± 41 ug/mL), fish oil-TG (mean = 108 ± 40 ug/mL), and krill oil (mean = 118.5 ± 48 ug/mL), p = 0.052 and bioavailability differed by < 24 % between the groups. Additionally, DHA + EPA levels were not significantly different in RBCs among the 3 formulations, p = 0.19, providing comparable omega-3 indexes.

CONCLUSIONS

Similar plasma and RBC levels of EPA + DHA were achieved across fish oil and krill oil products when matched for dose, EPA, and DHA concentrations in this four week study, indicating comparable oral bioavailability irrespective of formulation.

TRIAL REGISTRATION

Clinicaltrials.gov identifier NCT02427373.

Authors+Show Affiliations

DSM Nutritional Products, Columbia, MD, USA. karin.yurko-mauro@dsm.com.DSM Nutritional Products, Dartmouth, NS, USA. Jaroslav.Kralovec@dsm.com.DSM Nutritional Products, Columbia, MD, USA. Eileen.Bailey@dsm.com.Worldwide Clinical Trials, San Antonio, TX, USA. Vanessa.Smeberg@wwctrials.com.Worldwide Clinical Trials, San Antonio, TX, USA. Jeff.Stark@wwctrials.com.DSM Nutritional Products, Columbia, MD, USA. Norman.Salem@dsm.com.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

26328782

Citation

Yurko-Mauro, Karin, et al. "Similar Eicosapentaenoic Acid and Docosahexaenoic Acid Plasma Levels Achieved With Fish Oil or Krill Oil in a Randomized Double-blind Four-week Bioavailability Study." Lipids in Health and Disease, vol. 14, 2015, p. 99.
Yurko-Mauro K, Kralovec J, Bailey-Hall E, et al. Similar eicosapentaenoic acid and docosahexaenoic acid plasma levels achieved with fish oil or krill oil in a randomized double-blind four-week bioavailability study. Lipids Health Dis. 2015;14:99.
Yurko-Mauro, K., Kralovec, J., Bailey-Hall, E., Smeberg, V., Stark, J. G., & Salem, N. (2015). Similar eicosapentaenoic acid and docosahexaenoic acid plasma levels achieved with fish oil or krill oil in a randomized double-blind four-week bioavailability study. Lipids in Health and Disease, 14, p. 99. doi:10.1186/s12944-015-0109-z.
Yurko-Mauro K, et al. Similar Eicosapentaenoic Acid and Docosahexaenoic Acid Plasma Levels Achieved With Fish Oil or Krill Oil in a Randomized Double-blind Four-week Bioavailability Study. Lipids Health Dis. 2015 Sep 2;14:99. PubMed PMID: 26328782.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Similar eicosapentaenoic acid and docosahexaenoic acid plasma levels achieved with fish oil or krill oil in a randomized double-blind four-week bioavailability study. AU - Yurko-Mauro,Karin, AU - Kralovec,Jaroslav, AU - Bailey-Hall,Eileen, AU - Smeberg,Vanessa, AU - Stark,Jeffrey G, AU - Salem,Norman,Jr Y1 - 2015/09/02/ PY - 2015/04/20/received PY - 2015/08/27/accepted PY - 2015/9/3/entrez PY - 2015/9/4/pubmed PY - 2016/5/19/medline SP - 99 EP - 99 JF - Lipids in health and disease JO - Lipids Health Dis VL - 14 N2 - BACKGROUND: Long-chain n-3 polyunsaturated fatty acids (LC n-3-PUFA), docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) provide multiple health benefits for heart, brain and eyes. However, consumption of fatty fish, the main source of LC n-3-PUFAs is low in Western countries. Intakes of LC n-3-PUFA can be increased by taking dietary supplements, such as fish oil, algal oil, or krill oil. Recently, conflicting information was published on the relative bioavailability of these omega-3 supplements. A few studies suggested that the phospholipid form (krill) is better absorbed than the fish oil ethyl ester (EE) or triglyceride (TG) forms. Yet studies did not match the doses administered nor the concentrations of DHA and EPA per supplement across such comparisons, leading to questionable conclusions. This study was designed to compare the oral bioavailability of the same dose of both EPA and DHA in fish oil-EE vs. fish oil-TG vs. krill oil in plasma at the end of a four-week supplementation. METHODS: Sixty-six healthy adults (n = 22/arm) were enrolled in a double blind, randomized, three-treatment, multi-dose, parallel study. Subjects were supplemented with a 1.3 g/d dose of EPA + DHA (approximately 816 mg/d EPA + 522 mg/d DHA, regardless of formulation) for 28 consecutive days, as either fish oil-EE, fish oil-TG or krill oil capsules (6 caps/day). Plasma and red blood cell (RBC) samples were collected at baseline (pre-dose on Day 1) and at 4, 8, 12, 48, 72, 336, and 672 h. Total plasma EPA + DHA levels at Week 4 (Hour 672) were measured as the primary endpoint. RESULTS: No significant differences in total plasma EPA + DHA at 672 h were observed between fish oil-EE (mean = 90.9 ± 41 ug/mL), fish oil-TG (mean = 108 ± 40 ug/mL), and krill oil (mean = 118.5 ± 48 ug/mL), p = 0.052 and bioavailability differed by < 24 % between the groups. Additionally, DHA + EPA levels were not significantly different in RBCs among the 3 formulations, p = 0.19, providing comparable omega-3 indexes. CONCLUSIONS: Similar plasma and RBC levels of EPA + DHA were achieved across fish oil and krill oil products when matched for dose, EPA, and DHA concentrations in this four week study, indicating comparable oral bioavailability irrespective of formulation. TRIAL REGISTRATION: Clinicaltrials.gov identifier NCT02427373. SN - 1476-511X UR - https://www.unboundmedicine.com/medline/citation/26328782/Similar_eicosapentaenoic_acid_and_docosahexaenoic_acid_plasma_levels_achieved_with_fish_oil_or_krill_oil_in_a_randomized_double_blind_four_week_bioavailability_study_ L2 - https://lipidworld.biomedcentral.com/articles/10.1186/s12944-015-0109-z DB - PRIME DP - Unbound Medicine ER -