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Plasma fibrinogen levels are correlated with postoperative distant metastasis and prognosis in esophageal squamous cell carcinoma.
Oncotarget. 2015 Nov 10; 6(35):38410-20.O

Abstract

This study investigated the correlation of preoperative plasma fibrinogen level with distant metastasis and prognosis in esophageal squamous cell carcinoma (ESCC). A total of 255 patients with ESCC who underwent surgery in Zhejiang cancer hospital (Hangzhou, China), between October 2006 and December 2009, were evaluated in this retrospective study. Population controls were selected from a pool of cancer-free subjects in the same region. Each patient and cancer-free people provided 3-mL pretreatment blood. Plasma fibrinogen level was measured by the Clauss method. The effects of hyperfibrinogenemia on locoregional relapse-free survival (LRFS), distant metastasis-free survival (DMFS), relapse-free survival (RFS), and overall survival (OS) were assessed using Kaplan-Meier analysis. Independent prognostic factors were identified in the multivariate Cox analysis. The proportion of hyperfibrinogenemia was higher in ESCC patients than those in controls (40.4% vs 13.6%). Subjects with hyperfibrinogenemia had a significantly higher risk of ESCC than those with normal plasma fibrinogen level (adjust OR = 4.61; 95% CI = 3.02-7.01, P < 0.001) after adjusted for age, sex and smoking status. The Kaplan-Meier curves showed that patients with hyperfibrinogenemia had worse DMFS, RFS and OS (P < 0.001). Tumor length, lymph node metastasis and plasma fibrinogen level were independent prognostic factors of ESCC (P < 0.05). Increased plasma fibrinogen level was significantly associated with elevated risk of ESCC. Preoperative plasma fibrinogen level was a predictor of distant metastasis and independently associated with prognosis of patients with ESCC.

Authors+Show Affiliations

Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China. Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang, China.Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China. Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang, China.Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China. Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang, China.Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China. Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang, China.Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China. Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang, China.Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China. Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang, China.Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China. Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang, China.Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China. Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang, China.Department of Radiotherapy, Zhejiang Cancer Hospital, Hangzhou, Zhejiang, China. Key Laboratory Diagnosis and Treatment Technology on Thoracic Oncology, Zhejiang, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26334098

Citation

Zhang, Danhong, et al. "Plasma Fibrinogen Levels Are Correlated With Postoperative Distant Metastasis and Prognosis in Esophageal Squamous Cell Carcinoma." Oncotarget, vol. 6, no. 35, 2015, pp. 38410-20.
Zhang D, Zhou X, Bao W, et al. Plasma fibrinogen levels are correlated with postoperative distant metastasis and prognosis in esophageal squamous cell carcinoma. Oncotarget. 2015;6(35):38410-20.
Zhang, D., Zhou, X., Bao, W., Chen, Y., Cheng, L., Qiu, G., Sheng, L., Ji, Y., & Du, X. (2015). Plasma fibrinogen levels are correlated with postoperative distant metastasis and prognosis in esophageal squamous cell carcinoma. Oncotarget, 6(35), 38410-20. https://doi.org/10.18632/oncotarget.4800
Zhang D, et al. Plasma Fibrinogen Levels Are Correlated With Postoperative Distant Metastasis and Prognosis in Esophageal Squamous Cell Carcinoma. Oncotarget. 2015 Nov 10;6(35):38410-20. PubMed PMID: 26334098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma fibrinogen levels are correlated with postoperative distant metastasis and prognosis in esophageal squamous cell carcinoma. AU - Zhang,Danhong, AU - Zhou,Xia, AU - Bao,Wuan, AU - Chen,Ying, AU - Cheng,Lei, AU - Qiu,Guoqin, AU - Sheng,Liming, AU - Ji,Yongling, AU - Du,Xianghui, PY - 2015/03/21/received PY - 2015/07/23/accepted PY - 2015/9/4/entrez PY - 2015/9/4/pubmed PY - 2016/9/7/medline KW - esophageal squamous cell carcinoma KW - fibrinogen KW - metastasis KW - prognosis SP - 38410 EP - 20 JF - Oncotarget JO - Oncotarget VL - 6 IS - 35 N2 - This study investigated the correlation of preoperative plasma fibrinogen level with distant metastasis and prognosis in esophageal squamous cell carcinoma (ESCC). A total of 255 patients with ESCC who underwent surgery in Zhejiang cancer hospital (Hangzhou, China), between October 2006 and December 2009, were evaluated in this retrospective study. Population controls were selected from a pool of cancer-free subjects in the same region. Each patient and cancer-free people provided 3-mL pretreatment blood. Plasma fibrinogen level was measured by the Clauss method. The effects of hyperfibrinogenemia on locoregional relapse-free survival (LRFS), distant metastasis-free survival (DMFS), relapse-free survival (RFS), and overall survival (OS) were assessed using Kaplan-Meier analysis. Independent prognostic factors were identified in the multivariate Cox analysis. The proportion of hyperfibrinogenemia was higher in ESCC patients than those in controls (40.4% vs 13.6%). Subjects with hyperfibrinogenemia had a significantly higher risk of ESCC than those with normal plasma fibrinogen level (adjust OR = 4.61; 95% CI = 3.02-7.01, P < 0.001) after adjusted for age, sex and smoking status. The Kaplan-Meier curves showed that patients with hyperfibrinogenemia had worse DMFS, RFS and OS (P < 0.001). Tumor length, lymph node metastasis and plasma fibrinogen level were independent prognostic factors of ESCC (P < 0.05). Increased plasma fibrinogen level was significantly associated with elevated risk of ESCC. Preoperative plasma fibrinogen level was a predictor of distant metastasis and independently associated with prognosis of patients with ESCC. SN - 1949-2553 UR - https://www.unboundmedicine.com/medline/citation/26334098/Plasma_fibrinogen_levels_are_correlated_with_postoperative_distant_metastasis_and_prognosis_in_esophageal_squamous_cell_carcinoma_ L2 - https://www.oncotarget.com/lookup/doi/10.18632/oncotarget.4800 DB - PRIME DP - Unbound Medicine ER -