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Associations of Bone Mineral Density with Lean Mass, Fat Mass, and Dietary Patterns in Postmenopausal Chinese Women: A 2-Year Prospective Study.
PLoS One. 2015; 10(9):e0137097.Plos

Abstract

OBJECTIVE

To assess factors associated with bone mineral density (BMD) in postmenopausal women in a longitudinal study, and to examine the relative contribution of lean mass, fat mass, dietary patterns, and years since menopause to BMD.

METHODS

Two hundred and eighty-two postmenopausal women were randomly selected from Hongqi Community Health Center, in Harbin City, China. All participants were followed up from 2009 to 2011. Dietary data were collected using a Food Frequency Questionnaire. BMD of the left hip, the lumbar spine, and the total body, and the body composition were measured by dual-energy X-ray absorptiometry at baseline and follow-up.

RESULTS

Lean mass and fat mass were positively associated with BMD of the spine, hip, and the total body at both baseline and follow-up. The association between fat mass and BMD at the spine at baseline (P = 0.210) and at the spine (P = 0.116) and hip (P = 0.073) in the second year was not statistically significant when height was adjusted. Six dietary patterns were identified but only cereal grains-fruits pattern (P = 0.001 in the spine, P = 0.037 in hip) and milk-root vegetables pattern (P = 0.010 in hip) were associated with BMD of the spine and hip. The linear mixed model of follow-up data showed that lean mass, years since menopause, and age of menophania were the significant determinants of BMD of all sites. Moreover, lean mass was the best determinant of BMD (VIP = 1.936).

CONCLUSION

Lean mass, years since menopause, age of menophania and dietary patterns are the important determinants of BMD of the spine, hip, and the total body. Lean mass is the best determinant of BMD.

Authors+Show Affiliations

Department of Biostatistics, Public Health College, Harbin Medical University, Harbin City, Heilongjiang Province, China.Department of Biostatistics, Public Health College, Harbin Medical University, Harbin City, Heilongjiang Province, China.School of Medicine, University of Queensland, Royal Brisbane & Women's Hospital, Brisbane, Queensland, Australia.Department of Biostatistics, Public Health College, Harbin Medical University, Harbin City, Heilongjiang Province, China.The First People's Hospital of Tengzhou, Zaozhuang City, Shandong Province, China.Department of Epidemiology and Evidence-based Medicine, Public Health College, Changsha Medical University, Changsha City, Hunan Province, China.The Harbin Institute of Technology Hospital, Harbin City, Heilongjiang Province, China.Department of Biostatistics, Public Health College, Harbin Medical University, Harbin City, Heilongjiang Province, China.Department of Biostatistics, Public Health College, Harbin Medical University, Harbin City, Heilongjiang Province, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26335921

Citation

Chen, Yongjie, et al. "Associations of Bone Mineral Density With Lean Mass, Fat Mass, and Dietary Patterns in Postmenopausal Chinese Women: a 2-Year Prospective Study." PloS One, vol. 10, no. 9, 2015, pp. e0137097.
Chen Y, Xiang J, Wang Z, et al. Associations of Bone Mineral Density with Lean Mass, Fat Mass, and Dietary Patterns in Postmenopausal Chinese Women: A 2-Year Prospective Study. PLoS ONE. 2015;10(9):e0137097.
Chen, Y., Xiang, J., Wang, Z., Xiao, Y., Zhang, D., Chen, X., Li, H., Liu, M., & Zhang, Q. (2015). Associations of Bone Mineral Density with Lean Mass, Fat Mass, and Dietary Patterns in Postmenopausal Chinese Women: A 2-Year Prospective Study. PloS One, 10(9), e0137097. https://doi.org/10.1371/journal.pone.0137097
Chen Y, et al. Associations of Bone Mineral Density With Lean Mass, Fat Mass, and Dietary Patterns in Postmenopausal Chinese Women: a 2-Year Prospective Study. PLoS ONE. 2015;10(9):e0137097. PubMed PMID: 26335921.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations of Bone Mineral Density with Lean Mass, Fat Mass, and Dietary Patterns in Postmenopausal Chinese Women: A 2-Year Prospective Study. AU - Chen,Yongjie, AU - Xiang,Jing, AU - Wang,Zhiqiang, AU - Xiao,Yaming, AU - Zhang,Dongmei, AU - Chen,Xia, AU - Li,Huiting, AU - Liu,Meina, AU - Zhang,Qiuju, Y1 - 2015/09/03/ PY - 2015/03/20/received PY - 2015/08/12/accepted PY - 2015/9/4/entrez PY - 2015/9/4/pubmed PY - 2016/5/25/medline SP - e0137097 EP - e0137097 JF - PloS one JO - PLoS ONE VL - 10 IS - 9 N2 - OBJECTIVE: To assess factors associated with bone mineral density (BMD) in postmenopausal women in a longitudinal study, and to examine the relative contribution of lean mass, fat mass, dietary patterns, and years since menopause to BMD. METHODS: Two hundred and eighty-two postmenopausal women were randomly selected from Hongqi Community Health Center, in Harbin City, China. All participants were followed up from 2009 to 2011. Dietary data were collected using a Food Frequency Questionnaire. BMD of the left hip, the lumbar spine, and the total body, and the body composition were measured by dual-energy X-ray absorptiometry at baseline and follow-up. RESULTS: Lean mass and fat mass were positively associated with BMD of the spine, hip, and the total body at both baseline and follow-up. The association between fat mass and BMD at the spine at baseline (P = 0.210) and at the spine (P = 0.116) and hip (P = 0.073) in the second year was not statistically significant when height was adjusted. Six dietary patterns were identified but only cereal grains-fruits pattern (P = 0.001 in the spine, P = 0.037 in hip) and milk-root vegetables pattern (P = 0.010 in hip) were associated with BMD of the spine and hip. The linear mixed model of follow-up data showed that lean mass, years since menopause, and age of menophania were the significant determinants of BMD of all sites. Moreover, lean mass was the best determinant of BMD (VIP = 1.936). CONCLUSION: Lean mass, years since menopause, age of menophania and dietary patterns are the important determinants of BMD of the spine, hip, and the total body. Lean mass is the best determinant of BMD. SN - 1932-6203 UR - https://www.unboundmedicine.com/medline/citation/26335921/Associations_of_Bone_Mineral_Density_with_Lean_Mass_Fat_Mass_and_Dietary_Patterns_in_Postmenopausal_Chinese_Women:_A_2_Year_Prospective_Study_ L2 - http://dx.plos.org/10.1371/journal.pone.0137097 DB - PRIME DP - Unbound Medicine ER -