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Hypovitaminosis D is associated with lower urinary tract symptoms and benign prostate hyperplasia in type 2 diabetes.
Andrology. 2015 Nov; 3(6):1062-7.A

Abstract

Lower urinary tract symptoms (LUTS) may develop more commonly in men with type 2 diabetes mellitus (T2DM). LUTS are often associated with benign prostate hyperplasia (BPH), in general population. An association between LUTS and hypovitaminosis D, and between hypovitaminosis D and type 2 diabetes (T2DM), has also been suggested. Thus, we aim to evaluate possible relationships between hypovitaminosis D, LUTS, and BPH in T2DM men. In this prospective observational study, 67 T2DM males (57.9 ± 9.28 years) underwent medical history collection, International Prostate Symptom Score (IPSS) questionnaire, that allows the identification and grading of LUTS, physical examination, biochemical/hormonal blood tests (fasting plasma glucose, glycated haemoglobin, total cholesterol, high-density lipoprotein cholesterol, triglycerides, creatinine, LH, total testosterone, estradiol (E2), 25-OH-vitamin D, PTH, calcium, phosphate, and PSA) and ultrasound transrectal prostate examination. Subdividing patients into three groups, on the base of 25-OH-vitamin D concentration (sufficiency ≥50; insufficiency >25 < 50; and deficiency ≤25 nm), a significant progressive increase of prostate volume (p = 0.037), IPSS score (p = 0.019), diastolic blood pressure (p = 0.018), and a significant decrease in HDL cholesterol (p = 0.038) were observed. 25-OH-Vitamin D levels were inversely correlated with both IPSS (R = -0.333; p = 0.006) and prostate volume (R = -0.311; p = 0.011). At multivariate analysis, hypovitaminosis D remained an independent predictor of both IPSS and prostate volume. In conclusion, we showed, for the first time, an association between 25-OH-vitamin D deficiency, LUTS, and BPH in T2DM men.

Authors+Show Affiliations

Department of Medicine, Section of Endocrinology and Centre for Human Reproduction Pathology, University of Padova, Padova, Italy.Department of Medicine, Section of Diabetes and Metabolic Diseases, University of Padova, Padova, Italy.Department of Medicine, Section of Endocrinology and Centre for Human Reproduction Pathology, University of Padova, Padova, Italy.Department of Medicine, Section of Diabetes and Metabolic Diseases, University of Padova, Padova, Italy.Department of Medicine, Section of Endocrinology and Centre for Human Reproduction Pathology, University of Padova, Padova, Italy.Department of Medicine, Section of Endocrinology and Centre for Human Reproduction Pathology, University of Padova, Padova, Italy.Department of Medicine, Section of Diabetes and Metabolic Diseases, University of Padova, Padova, Italy.Department of Medicine, Section of Endocrinology and Centre for Human Reproduction Pathology, University of Padova, Padova, Italy.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26339755

Citation

Caretta, N, et al. "Hypovitaminosis D Is Associated With Lower Urinary Tract Symptoms and Benign Prostate Hyperplasia in Type 2 Diabetes." Andrology, vol. 3, no. 6, 2015, pp. 1062-7.
Caretta N, Vigili de Kreutzenberg S, Valente U, et al. Hypovitaminosis D is associated with lower urinary tract symptoms and benign prostate hyperplasia in type 2 diabetes. Andrology. 2015;3(6):1062-7.
Caretta, N., Vigili de Kreutzenberg, S., Valente, U., Guarneri, G., Pizzol, D., Ferlin, A., Avogaro, A., & Foresta, C. (2015). Hypovitaminosis D is associated with lower urinary tract symptoms and benign prostate hyperplasia in type 2 diabetes. Andrology, 3(6), 1062-7. https://doi.org/10.1111/andr.12092
Caretta N, et al. Hypovitaminosis D Is Associated With Lower Urinary Tract Symptoms and Benign Prostate Hyperplasia in Type 2 Diabetes. Andrology. 2015;3(6):1062-7. PubMed PMID: 26339755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypovitaminosis D is associated with lower urinary tract symptoms and benign prostate hyperplasia in type 2 diabetes. AU - Caretta,N, AU - Vigili de Kreutzenberg,S, AU - Valente,U, AU - Guarneri,G, AU - Pizzol,D, AU - Ferlin,A, AU - Avogaro,A, AU - Foresta,C, Y1 - 2015/09/04/ PY - 2015/01/21/received PY - 2015/06/24/revised PY - 2015/07/16/accepted PY - 2015/9/5/entrez PY - 2015/9/5/pubmed PY - 2016/11/1/medline KW - benign prostate hyperplasia KW - hypovitaminosis D KW - lower urinary tract symptoms KW - type 2 diabetes SP - 1062 EP - 7 JF - Andrology JO - Andrology VL - 3 IS - 6 N2 - Lower urinary tract symptoms (LUTS) may develop more commonly in men with type 2 diabetes mellitus (T2DM). LUTS are often associated with benign prostate hyperplasia (BPH), in general population. An association between LUTS and hypovitaminosis D, and between hypovitaminosis D and type 2 diabetes (T2DM), has also been suggested. Thus, we aim to evaluate possible relationships between hypovitaminosis D, LUTS, and BPH in T2DM men. In this prospective observational study, 67 T2DM males (57.9 ± 9.28 years) underwent medical history collection, International Prostate Symptom Score (IPSS) questionnaire, that allows the identification and grading of LUTS, physical examination, biochemical/hormonal blood tests (fasting plasma glucose, glycated haemoglobin, total cholesterol, high-density lipoprotein cholesterol, triglycerides, creatinine, LH, total testosterone, estradiol (E2), 25-OH-vitamin D, PTH, calcium, phosphate, and PSA) and ultrasound transrectal prostate examination. Subdividing patients into three groups, on the base of 25-OH-vitamin D concentration (sufficiency ≥50; insufficiency >25 < 50; and deficiency ≤25 nm), a significant progressive increase of prostate volume (p = 0.037), IPSS score (p = 0.019), diastolic blood pressure (p = 0.018), and a significant decrease in HDL cholesterol (p = 0.038) were observed. 25-OH-Vitamin D levels were inversely correlated with both IPSS (R = -0.333; p = 0.006) and prostate volume (R = -0.311; p = 0.011). At multivariate analysis, hypovitaminosis D remained an independent predictor of both IPSS and prostate volume. In conclusion, we showed, for the first time, an association between 25-OH-vitamin D deficiency, LUTS, and BPH in T2DM men. SN - 2047-2927 UR - https://www.unboundmedicine.com/medline/citation/26339755/Hypovitaminosis_D_is_associated_with_lower_urinary_tract_symptoms_and_benign_prostate_hyperplasia_in_type_2_diabetes_ L2 - https://doi.org/10.1111/andr.12092 DB - PRIME DP - Unbound Medicine ER -