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Electrophysiological assessments of the motor pathway in diabetic patients with compressive cervical myelopathy.
J Neurosurg Spine. 2015 Dec; 23(6):707-14.JN

Abstract

OBJECT

The occurrence of compressive cervical myelopathy (CCM) increases in adults over 50 years of age. In addition, diabetes mellitus (DM) is a frequent comorbidity for people of this age and may impact the severity of CCM. The authors assessed motor pathway function in diabetic patients with CCM to investigate the correlation between electrophysiological parameters and clinical symptoms.

METHODS

Motor evoked potentials (MEPs) were measured from the abductor digiti minimi muscle (ADM) and the abductor hallucis muscle (AH) following transcranial magnetic stimulation, as were M- and F-waves following electrical stimulation of the ulnar and tibial nerves, in 22 patients with CCM and diabetes mellitus (DM) who had not experienced symptomatic diabetic neuropathy (CCM-DM group), in 92 patients with CCM alone (CCM group), and in 24 healthy adults (control group). The peripheral conduction time (PCT; measured from the ADM and AH) was calculated as follows: (M-wave latency + F-wave latency -1)/2. The central motor conduction time (CMCT; measured from the ADM and AH) was calculated by subtracting the PCT from the onset latency of the MEPs. The Japanese Orthopaedic Association (JOA) score for cervical myelopathy was obtained before and 1 year after surgery as a clinical outcome measure.

RESULTS

MEP, PCT, and CMCT parameters in the CCM-DM and CCM groups were significantly longer than those in the control group (p = 0.000-0.007). The PCTs in the CCM-DM group were significantly longer than those in the CCM group (p = 0.001-0.003). No significant differences were detected in the MEP and CMCT parameters between the CCM-DM and CCM groups (p = 0.080-1.000). The JOA score before surgery in the CCM-DM group was 10.7 ± 2.0 points and was significantly lower than that in the CCM group (12.2 ± 2.5 points, p = 0.015). In the CCM-DM group, JOA scores before surgery correlated with MEP-AH (r = -0.610, p = 0.012) and PCT-AH (r = -0.676, p = 0.004) values, but not with CMCT values, while the JOA scores were related to both MEP and CMCT parameters in the CCM group. The JOA scores improved to 13.8 ± 2.2 points after surgery (p = 0.001) and correlated with MEP-AH (r = -0.667, p = 0.005) and PCT-AH (r = -0.611, p = 0.012) in the CCM-DM group.

CONCLUSIONS

The results suggest that MEP, PCT, and CMCT parameters each reveal abnormalities in the upper and lower motor neurons even in patients with DM. The results also show a prolonged PCT in CCM-DM patients, despite having no history of diabetic neuropathy. Corticospinal tract impairments are similar between CCM and CCM-DM patients, while the JOA score of the CCM-DM patients is lower than that in the CCM patients. The JOA score in CCM-DM patients may be influenced by additional impairments in peripheral nerves or other diabetic complications. These electrophysiological studies may be useful for screening motor pathway function for CCM in patients with DM.

Authors+Show Affiliations

Department of Orthopedic Surgery, Integrated Health Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.Department of Orthopedic Surgery, Integrated Health Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.Department of Orthopedic Surgery, Integrated Health Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.Department of Orthopedic Surgery, Integrated Health Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.Department of Orthopedic Surgery, Integrated Health Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.Department of Orthopedic Surgery, Integrated Health Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.Department of Orthopedic Surgery, Integrated Health Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.Department of Orthopedic Surgery, Integrated Health Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.Department of Orthopedic Surgery, Integrated Health Sciences, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26340381

Citation

Nakanishi, Kazuyoshi, et al. "Electrophysiological Assessments of the Motor Pathway in Diabetic Patients With Compressive Cervical Myelopathy." Journal of Neurosurgery. Spine, vol. 23, no. 6, 2015, pp. 707-14.
Nakanishi K, Tanaka N, Kamei N, et al. Electrophysiological assessments of the motor pathway in diabetic patients with compressive cervical myelopathy. J Neurosurg Spine. 2015;23(6):707-14.
Nakanishi, K., Tanaka, N., Kamei, N., Hiramatsu, T., Ujigo, S., Sumiyoshi, N., Rikita, T., Takazawa, A., & Ochi, M. (2015). Electrophysiological assessments of the motor pathway in diabetic patients with compressive cervical myelopathy. Journal of Neurosurgery. Spine, 23(6), 707-14. https://doi.org/10.3171/2015.3.SPINE141060
Nakanishi K, et al. Electrophysiological Assessments of the Motor Pathway in Diabetic Patients With Compressive Cervical Myelopathy. J Neurosurg Spine. 2015;23(6):707-14. PubMed PMID: 26340381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrophysiological assessments of the motor pathway in diabetic patients with compressive cervical myelopathy. AU - Nakanishi,Kazuyoshi, AU - Tanaka,Nobuhiro, AU - Kamei,Naosuke, AU - Hiramatsu,Takeshi, AU - Ujigo,Satoshi, AU - Sumiyoshi,Norihiko, AU - Rikita,Takanori, AU - Takazawa,Atsushi, AU - Ochi,Mitsuo, Y1 - 2015/09/04/ PY - 2015/9/5/entrez PY - 2015/9/5/pubmed PY - 2016/4/8/medline KW - ADM = abductor digiti minimi muscle KW - AH = abductor hallucis muscle KW - BMI = body mass index KW - CCM = compressive cervical myelopathy KW - CMAP = compound muscle action potential KW - CMCT = central motor conduction time KW - CSM = cervical spondylotic myelopathy KW - DM = diabetes mellitus KW - F-wave KW - JOA = Japanese Orthopaedic Association KW - MEP = motor evoked potential KW - OPLL = ossification of the posterior longitudinal ligament KW - PCT = peripheral conduction time KW - TMS = transcranial magnetic stimulation KW - central motor conduction time KW - cervical KW - cervical myelopathy KW - corticospinal tract KW - diabetes mellitus KW - motor evoked potentials KW - peripheral conduction time KW - transcranial magnetic stimulation SP - 707 EP - 14 JF - Journal of neurosurgery. Spine JO - J Neurosurg Spine VL - 23 IS - 6 N2 - OBJECT: The occurrence of compressive cervical myelopathy (CCM) increases in adults over 50 years of age. In addition, diabetes mellitus (DM) is a frequent comorbidity for people of this age and may impact the severity of CCM. The authors assessed motor pathway function in diabetic patients with CCM to investigate the correlation between electrophysiological parameters and clinical symptoms. METHODS: Motor evoked potentials (MEPs) were measured from the abductor digiti minimi muscle (ADM) and the abductor hallucis muscle (AH) following transcranial magnetic stimulation, as were M- and F-waves following electrical stimulation of the ulnar and tibial nerves, in 22 patients with CCM and diabetes mellitus (DM) who had not experienced symptomatic diabetic neuropathy (CCM-DM group), in 92 patients with CCM alone (CCM group), and in 24 healthy adults (control group). The peripheral conduction time (PCT; measured from the ADM and AH) was calculated as follows: (M-wave latency + F-wave latency -1)/2. The central motor conduction time (CMCT; measured from the ADM and AH) was calculated by subtracting the PCT from the onset latency of the MEPs. The Japanese Orthopaedic Association (JOA) score for cervical myelopathy was obtained before and 1 year after surgery as a clinical outcome measure. RESULTS: MEP, PCT, and CMCT parameters in the CCM-DM and CCM groups were significantly longer than those in the control group (p = 0.000-0.007). The PCTs in the CCM-DM group were significantly longer than those in the CCM group (p = 0.001-0.003). No significant differences were detected in the MEP and CMCT parameters between the CCM-DM and CCM groups (p = 0.080-1.000). The JOA score before surgery in the CCM-DM group was 10.7 ± 2.0 points and was significantly lower than that in the CCM group (12.2 ± 2.5 points, p = 0.015). In the CCM-DM group, JOA scores before surgery correlated with MEP-AH (r = -0.610, p = 0.012) and PCT-AH (r = -0.676, p = 0.004) values, but not with CMCT values, while the JOA scores were related to both MEP and CMCT parameters in the CCM group. The JOA scores improved to 13.8 ± 2.2 points after surgery (p = 0.001) and correlated with MEP-AH (r = -0.667, p = 0.005) and PCT-AH (r = -0.611, p = 0.012) in the CCM-DM group. CONCLUSIONS: The results suggest that MEP, PCT, and CMCT parameters each reveal abnormalities in the upper and lower motor neurons even in patients with DM. The results also show a prolonged PCT in CCM-DM patients, despite having no history of diabetic neuropathy. Corticospinal tract impairments are similar between CCM and CCM-DM patients, while the JOA score of the CCM-DM patients is lower than that in the CCM patients. The JOA score in CCM-DM patients may be influenced by additional impairments in peripheral nerves or other diabetic complications. These electrophysiological studies may be useful for screening motor pathway function for CCM in patients with DM. SN - 1547-5646 UR - https://www.unboundmedicine.com/medline/citation/26340381/Electrophysiological_assessments_of_the_motor_pathway_in_diabetic_patients_with_compressive_cervical_myelopathy_ L2 - https://thejns.org/doi/10.3171/2015.3.SPINE141060 DB - PRIME DP - Unbound Medicine ER -