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Cannabidiol as a Potential Treatment for Anxiety Disorders.
Neurotherapeutics. 2015 Oct; 12(4):825-36.N

Abstract

Cannabidiol (CBD), a Cannabis sativa constituent, is a pharmacologically broad-spectrum drug that in recent years has drawn increasing interest as a treatment for a range of neuropsychiatric disorders. The purpose of the current review is to determine CBD's potential as a treatment for anxiety-related disorders, by assessing evidence from preclinical, human experimental, clinical, and epidemiological studies. We found that existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder when administered acutely; however, few studies have investigated chronic CBD dosing. Likewise, evidence from human studies supports an anxiolytic role of CBD, but is currently limited to acute dosing, also with few studies in clinical populations. Overall, current evidence indicates CBD has considerable potential as a treatment for multiple anxiety disorders, with need for further study of chronic and therapeutic effects in relevant clinical populations.

Authors+Show Affiliations

New York University School of Medicine, New York, NY, USA. esther.blessing@nyumc.org.New York University School of Medicine, New York, NY, USA.New York University School of Medicine, New York, NY, USA. Instituto de Neurociencias de Alicante, Universidad Miguel Hernández and Consejo Superior de Investigaciones Científicas, Alicante, Spain.New York University School of Medicine, New York, NY, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

26341731

Citation

Blessing, Esther M., et al. "Cannabidiol as a Potential Treatment for Anxiety Disorders." Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics, vol. 12, no. 4, 2015, pp. 825-36.
Blessing EM, Steenkamp MM, Manzanares J, et al. Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics. 2015;12(4):825-36.
Blessing, E. M., Steenkamp, M. M., Manzanares, J., & Marmar, C. R. (2015). Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics, 12(4), 825-36. https://doi.org/10.1007/s13311-015-0387-1
Blessing EM, et al. Cannabidiol as a Potential Treatment for Anxiety Disorders. Neurotherapeutics. 2015;12(4):825-36. PubMed PMID: 26341731.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cannabidiol as a Potential Treatment for Anxiety Disorders. AU - Blessing,Esther M, AU - Steenkamp,Maria M, AU - Manzanares,Jorge, AU - Marmar,Charles R, PY - 2015/9/6/entrez PY - 2015/9/6/pubmed PY - 2016/7/23/medline KW - Anxiety KW - Cannabidiol KW - Endocannabinoids KW - Generalized anxiety disorder KW - Post-traumatic stress disorder SP - 825 EP - 36 JF - Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics JO - Neurotherapeutics VL - 12 IS - 4 N2 - Cannabidiol (CBD), a Cannabis sativa constituent, is a pharmacologically broad-spectrum drug that in recent years has drawn increasing interest as a treatment for a range of neuropsychiatric disorders. The purpose of the current review is to determine CBD's potential as a treatment for anxiety-related disorders, by assessing evidence from preclinical, human experimental, clinical, and epidemiological studies. We found that existing preclinical evidence strongly supports CBD as a treatment for generalized anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder, and post-traumatic stress disorder when administered acutely; however, few studies have investigated chronic CBD dosing. Likewise, evidence from human studies supports an anxiolytic role of CBD, but is currently limited to acute dosing, also with few studies in clinical populations. Overall, current evidence indicates CBD has considerable potential as a treatment for multiple anxiety disorders, with need for further study of chronic and therapeutic effects in relevant clinical populations. SN - 1878-7479 UR - https://www.unboundmedicine.com/medline/citation/26341731/Cannabidiol_as_a_Potential_Treatment_for_Anxiety_Disorders_ L2 - https://dx.doi.org/10.1007/s13311-015-0387-1 DB - PRIME DP - Unbound Medicine ER -