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Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial.
Arch Med Res. 2015 Oct; 46(7):527-33.AM

Abstract

BACKGROUNDS AND AIMS

Overproduction of proinflammatory cytokines is a main trait of rheumatoid arthritis. Coenzyme Q10 (CoQ10), an endogenous antioxidant, has shown anti-inflammatory effects in some diseases. In this study we aimed to assess the effects of CoQ10 supplementation on cytokines generation and oxidative stress in rheumatoid arthritis.

METHODS

In this double-blind, randomized controlled clinical trial, 44 patients with rheumatoid arthritis were recruited. Twenty two patients received 100 mg/day capsules of CoQ10 and 22 patients took placebo for 2 months. At the beginning and the end of the intervention, 7 mL of fasting blood was taken from patients to measure malondialdehyde (MDA), total antioxidant capacity (TAC), interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α).

RESULTS

At the end of the study, serum MDA significantly decreased in supplemented group (mean difference = -1.47 nmol/mL; 95% confidence interval (CI), -2.52 to -0.43; p = 0.008). CoQ10 also suppressed overexpression of TNF-α (difference in median was +1.1 in placebo vs. +0.03 in CoQ10 group; p = 0.033). There was no significant difference in TAC and IL-6 levels between groups.

CONCLUSIONS

This study showed beneficial effects of CoQ10 supplementation on inflammatory cytokines and oxidative stress in rheumatoid arthritis patients.

Authors+Show Affiliations

Students' Research Committee, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Rheumatology, Faculty of Medicine, Urmia University of Medical Sciences, Urmia, Iran.Road Traffic Injury Research Center, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Community Nutrition, Faculty of Nutrition, Tabriz University of Medical Sciences, Tabriz, Iran. Electronic address: alipourb@tbzmed.ac.ir.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26342738

Citation

Abdollahzad, Hadi, et al. "Effects of Coenzyme Q10 Supplementation On Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: a Randomized Controlled Trial." Archives of Medical Research, vol. 46, no. 7, 2015, pp. 527-33.
Abdollahzad H, Aghdashi MA, Asghari Jafarabadi M, et al. Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial. Arch Med Res. 2015;46(7):527-33.
Abdollahzad, H., Aghdashi, M. A., Asghari Jafarabadi, M., & Alipour, B. (2015). Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial. Archives of Medical Research, 46(7), 527-33. https://doi.org/10.1016/j.arcmed.2015.08.006
Abdollahzad H, et al. Effects of Coenzyme Q10 Supplementation On Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: a Randomized Controlled Trial. Arch Med Res. 2015;46(7):527-33. PubMed PMID: 26342738.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of Coenzyme Q10 Supplementation on Inflammatory Cytokines (TNF-α, IL-6) and Oxidative Stress in Rheumatoid Arthritis Patients: A Randomized Controlled Trial. AU - Abdollahzad,Hadi, AU - Aghdashi,Mir Amir, AU - Asghari Jafarabadi,Mohammad, AU - Alipour,Beitollah, Y1 - 2015/09/03/ PY - 2015/05/31/received PY - 2015/08/25/accepted PY - 2015/9/7/entrez PY - 2015/9/8/pubmed PY - 2016/7/1/medline KW - Coenzyme Q(10) (CoQ(10)) KW - Inflammatory cytokines KW - Oxidative stress KW - Rheumatoid arthritis KW - Ubiquinol SP - 527 EP - 33 JF - Archives of medical research JO - Arch. Med. Res. VL - 46 IS - 7 N2 - BACKGROUNDS AND AIMS: Overproduction of proinflammatory cytokines is a main trait of rheumatoid arthritis. Coenzyme Q10 (CoQ10), an endogenous antioxidant, has shown anti-inflammatory effects in some diseases. In this study we aimed to assess the effects of CoQ10 supplementation on cytokines generation and oxidative stress in rheumatoid arthritis. METHODS: In this double-blind, randomized controlled clinical trial, 44 patients with rheumatoid arthritis were recruited. Twenty two patients received 100 mg/day capsules of CoQ10 and 22 patients took placebo for 2 months. At the beginning and the end of the intervention, 7 mL of fasting blood was taken from patients to measure malondialdehyde (MDA), total antioxidant capacity (TAC), interleukin (IL)-6 and tumor necrosis factor alpha (TNF-α). RESULTS: At the end of the study, serum MDA significantly decreased in supplemented group (mean difference = -1.47 nmol/mL; 95% confidence interval (CI), -2.52 to -0.43; p = 0.008). CoQ10 also suppressed overexpression of TNF-α (difference in median was +1.1 in placebo vs. +0.03 in CoQ10 group; p = 0.033). There was no significant difference in TAC and IL-6 levels between groups. CONCLUSIONS: This study showed beneficial effects of CoQ10 supplementation on inflammatory cytokines and oxidative stress in rheumatoid arthritis patients. SN - 1873-5487 UR - https://www.unboundmedicine.com/medline/citation/26342738/Effects_of_Coenzyme_Q10_Supplementation_on_Inflammatory_Cytokines__TNF_α_IL_6__and_Oxidative_Stress_in_Rheumatoid_Arthritis_Patients:_A_Randomized_Controlled_Trial_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0188-4409(15)00238-6 DB - PRIME DP - Unbound Medicine ER -