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Prudent diet may attenuate the adverse effects of Western diet on cognitive decline.
Alzheimers Dement 2016; 12(2):100-109AD

Abstract

INTRODUCTION

The influence of mixed dietary patterns on cognitive changes is unknown.

METHODS

A total of 2223 dementia-free participants aged ≥60 were followed up for 6 years to examine the impact of dietary patterns on cognitive decline. Mini-mental state examination (MMSE) was administered. Diet was assessed by a food frequency questionnaire. By factor analysis, Western and prudent dietary patterns emerged. Mixed-effect models for longitudinal data with repeated measurements were used.

RESULTS

Compared with the lowest adherence to each pattern, the highest adherence to prudent pattern was related to less MMSE decline (β = 0.106, P = .011), whereas the highest adherence to Western pattern was associated with more MMSE decline (β = -0.156, P < .001). The decline associated with Western diet was attenuated when accompanied by high adherence to prudent pattern.

DISCUSSION

High adherence to prudent diet may diminish the adverse effects of high adherence to Western diet on cognitive decline.

Authors+Show Affiliations

Aging Research Center, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden. Electronic address: behnaz.shakersain@ki.se.Aging Research Center, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.Unit of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Division of Clinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.Aging Research Center, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden.Aging Research Center, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Stockholm Gerontology Research Center, Stockholm, Sweden.Aging Research Center, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden; Department of Epidemiology and Biostatistics, School of Public Health, Tianjin Medical University, Tianjin, China. Electronic address: weili.xu@ki.se.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26342761

Citation

Shakersain, Behnaz, et al. "Prudent Diet May Attenuate the Adverse Effects of Western Diet On Cognitive Decline." Alzheimer's & Dementia : the Journal of the Alzheimer's Association, vol. 12, no. 2, 2016, pp. 100-109.
Shakersain B, Santoni G, Larsson SC, et al. Prudent diet may attenuate the adverse effects of Western diet on cognitive decline. Alzheimers Dement. 2016;12(2):100-109.
Shakersain, B., Santoni, G., Larsson, S. C., Faxén-Irving, G., Fastbom, J., Fratiglioni, L., & Xu, W. (2016). Prudent diet may attenuate the adverse effects of Western diet on cognitive decline. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 12(2), pp. 100-109. doi:10.1016/j.jalz.2015.08.002.
Shakersain B, et al. Prudent Diet May Attenuate the Adverse Effects of Western Diet On Cognitive Decline. Alzheimers Dement. 2016;12(2):100-109. PubMed PMID: 26342761.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prudent diet may attenuate the adverse effects of Western diet on cognitive decline. AU - Shakersain,Behnaz, AU - Santoni,Giola, AU - Larsson,Susanna C, AU - Faxén-Irving,Gerd, AU - Fastbom,Johan, AU - Fratiglioni,Laura, AU - Xu,Weili, Y1 - 2015/09/03/ PY - 2015/03/03/received PY - 2015/07/17/revised PY - 2015/08/02/accepted PY - 2015/9/7/entrez PY - 2015/9/8/pubmed PY - 2016/9/24/medline KW - Cognitive decline KW - Dietary patterns KW - Longitudinal study KW - Population-based SP - 100 EP - 109 JF - Alzheimer's & dementia : the journal of the Alzheimer's Association JO - Alzheimers Dement VL - 12 IS - 2 N2 - INTRODUCTION: The influence of mixed dietary patterns on cognitive changes is unknown. METHODS: A total of 2223 dementia-free participants aged ≥60 were followed up for 6 years to examine the impact of dietary patterns on cognitive decline. Mini-mental state examination (MMSE) was administered. Diet was assessed by a food frequency questionnaire. By factor analysis, Western and prudent dietary patterns emerged. Mixed-effect models for longitudinal data with repeated measurements were used. RESULTS: Compared with the lowest adherence to each pattern, the highest adherence to prudent pattern was related to less MMSE decline (β = 0.106, P = .011), whereas the highest adherence to Western pattern was associated with more MMSE decline (β = -0.156, P < .001). The decline associated with Western diet was attenuated when accompanied by high adherence to prudent pattern. DISCUSSION: High adherence to prudent diet may diminish the adverse effects of high adherence to Western diet on cognitive decline. SN - 1552-5279 UR - https://www.unboundmedicine.com/medline/citation/26342761/Prudent_diet_may_attenuate_the_adverse_effects_of_Western_diet_on_cognitive_decline_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1552-5260(15)02701-6 DB - PRIME DP - Unbound Medicine ER -