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The Role of Gluten in Celiac Disease and Type 1 Diabetes.

Abstract

Celiac disease (CD) and type 1 diabetes (T1D) are autoimmune conditions in which dietary gluten has been proven or suggested to play a pathogenic role. In CD; gluten is established as the instigator of autoimmunity; the autoimmune process is halted by removing gluten from the diet; which allows for resolution of celiac autoimmune enteropathy and subsequent normalization of serological markers of the disease. However; an analogous causative agent has not yet been identified for T1D. Nevertheless; the role of dietary gluten in development of T1D and the potentially beneficial effect of removing gluten from the diet of patients with T1D are still debated. In this review; we discuss the comorbid occurrence of CD and T1D and explore current evidences for the specific role of gluten in both conditions; specifically focusing on current evidence on the effect of gluten on the immune system and the gut microbiota.

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  • Authors+Show Affiliations

    ,

    Center for Celiac Research, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children, Boston, MA 02114, USA. gserena@mgh.harvard.edu. Graduate Program in Life Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA. gserena@mgh.harvard.edu.

    ,

    Center for Celiac Research, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children, Boston, MA 02114, USA. sscamhi@partners.org.

    ,

    Center for Celiac Research, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children, Boston, MA 02114, USA. csturgeon@mgh.harvard.edu. Graduate Program in Life Sciences, University of Maryland School of Medicine, Baltimore, MD 21201, USA. csturgeon@mgh.harvard.edu.

    ,

    Center for Celiac Research, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children, Boston, MA 02114, USA. syan4@mgh.harvard.edu.

    Center for Celiac Research, Mucosal Immunology and Biology Research Center, Massachusetts General Hospital and Division of Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital for Children, Boston, MA 02114, USA. afasano@mgh.harvard.edu.

    Source

    Nutrients 7:9 2015 Aug 26 pg 7143-62

    MeSH

    Animals
    Autoimmunity
    Celiac Disease
    Comorbidity
    Diabetes Mellitus, Type 1
    Diet, Gluten-Free
    Gastrointestinal Microbiome
    Glutens
    Humans
    Intestines
    Risk Factors
    Treatment Outcome

    Pub Type(s)

    Journal Article
    Review

    Language

    eng

    PubMed ID

    26343710

    Citation

    Serena, Gloria, et al. "The Role of Gluten in Celiac Disease and Type 1 Diabetes." Nutrients, vol. 7, no. 9, 2015, pp. 7143-62.
    Serena G, Camhi S, Sturgeon C, et al. The Role of Gluten in Celiac Disease and Type 1 Diabetes. Nutrients. 2015;7(9):7143-62.
    Serena, G., Camhi, S., Sturgeon, C., Yan, S., & Fasano, A. (2015). The Role of Gluten in Celiac Disease and Type 1 Diabetes. Nutrients, 7(9), pp. 7143-62. doi:10.3390/nu7095329.
    Serena G, et al. The Role of Gluten in Celiac Disease and Type 1 Diabetes. Nutrients. 2015 Aug 26;7(9):7143-62. PubMed PMID: 26343710.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - The Role of Gluten in Celiac Disease and Type 1 Diabetes. AU - Serena,Gloria, AU - Camhi,Stephanie, AU - Sturgeon,Craig, AU - Yan,Shu, AU - Fasano,Alessio, Y1 - 2015/08/26/ PY - 2015/06/26/received PY - 2015/08/10/revised PY - 2015/08/11/accepted PY - 2015/9/8/entrez PY - 2015/9/8/pubmed PY - 2016/6/30/medline KW - celiac disease KW - gluten KW - type 1 diabetes SP - 7143 EP - 62 JF - Nutrients JO - Nutrients VL - 7 IS - 9 N2 - Celiac disease (CD) and type 1 diabetes (T1D) are autoimmune conditions in which dietary gluten has been proven or suggested to play a pathogenic role. In CD; gluten is established as the instigator of autoimmunity; the autoimmune process is halted by removing gluten from the diet; which allows for resolution of celiac autoimmune enteropathy and subsequent normalization of serological markers of the disease. However; an analogous causative agent has not yet been identified for T1D. Nevertheless; the role of dietary gluten in development of T1D and the potentially beneficial effect of removing gluten from the diet of patients with T1D are still debated. In this review; we discuss the comorbid occurrence of CD and T1D and explore current evidences for the specific role of gluten in both conditions; specifically focusing on current evidence on the effect of gluten on the immune system and the gut microbiota. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26343710/full_citation L2 - http://www.mdpi.com/resolver?pii=nu7095329 DB - PRIME DP - Unbound Medicine ER -