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Associations between B Vitamins and Parkinson's Disease.

Abstract

B vitamins may correlate with Parkinson's disease (PD) through regulating homocysteine level. However, there is no comprehensive assessment on the associations between PD and B vitamins. The present study was designed to perform a meta-analytic assessment of the associations between folate, vitamin B6, and vitamin B12 and PD, including the status of B vitamins in PD patients compared with controls, and associations of dietary intakes of B vitamins and risk of PD. A literature search using Medline database obtained 10 eligible studies included in the meta-analyses. Stata 12.0 statistical software was used to perform the meta-analysis. Pooled data revealed that there was no obvious difference in folate level between PD patients and healthy controls, and PD patients had lower level of vitamin B12 than controls. Available data suggested that higher dietary intake of vitamin B6 was associated with a decreased risk of PD (odds ratio (OR) = 0.65, 95% confidence intervals (CI) = (0.30, 1.01)), while no significant association was observed for dietary intake of folate and vitamin B12 and risk of PD. PD patients had lower level of vitamin B12 and similar level of folate compared with controls. Dietary intake of vitamin B6 exhibited preventive effect of developing PD based on the available data. As the number of included studies is limited, more studies are needed to confirm the findings and elucidate the underpinning underlying these associations.

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  • Authors+Show Affiliations

    Shandong Provincial Research Center for Bioinformatic Engineering and Technique, School of Life Sciences, Shandong University of Technology, Zibo 255049, China. shen@sdut.edu.cn.

    Source

    Nutrients 7:9 2015 Aug 27 pg 7197-208

    MeSH

    Case-Control Studies
    Diet
    Folic Acid
    Humans
    Odds Ratio
    Parkinson Disease
    Protective Factors
    Risk Assessment
    Risk Factors
    Vitamin B 12
    Vitamin B 6
    Vitamin B Complex

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Research Support, Non-U.S. Gov't
    Review

    Language

    eng

    PubMed ID

    26343714

    Citation

    Shen, Liang. "Associations Between B Vitamins and Parkinson's Disease." Nutrients, vol. 7, no. 9, 2015, pp. 7197-208.
    Shen L. Associations between B Vitamins and Parkinson's Disease. Nutrients. 2015;7(9):7197-208.
    Shen, L. (2015). Associations between B Vitamins and Parkinson's Disease. Nutrients, 7(9), pp. 7197-208. doi:10.3390/nu7095333.
    Shen L. Associations Between B Vitamins and Parkinson's Disease. Nutrients. 2015 Aug 27;7(9):7197-208. PubMed PMID: 26343714.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Associations between B Vitamins and Parkinson's Disease. A1 - Shen,Liang, Y1 - 2015/08/27/ PY - 2015/07/03/received PY - 2015/08/15/revised PY - 2015/08/20/accepted PY - 2015/9/8/entrez PY - 2015/9/8/pubmed PY - 2016/6/30/medline KW - B vitamins KW - Parkinson’s disease KW - dietary intake KW - meta-analysis SP - 7197 EP - 208 JF - Nutrients JO - Nutrients VL - 7 IS - 9 N2 - B vitamins may correlate with Parkinson's disease (PD) through regulating homocysteine level. However, there is no comprehensive assessment on the associations between PD and B vitamins. The present study was designed to perform a meta-analytic assessment of the associations between folate, vitamin B6, and vitamin B12 and PD, including the status of B vitamins in PD patients compared with controls, and associations of dietary intakes of B vitamins and risk of PD. A literature search using Medline database obtained 10 eligible studies included in the meta-analyses. Stata 12.0 statistical software was used to perform the meta-analysis. Pooled data revealed that there was no obvious difference in folate level between PD patients and healthy controls, and PD patients had lower level of vitamin B12 than controls. Available data suggested that higher dietary intake of vitamin B6 was associated with a decreased risk of PD (odds ratio (OR) = 0.65, 95% confidence intervals (CI) = (0.30, 1.01)), while no significant association was observed for dietary intake of folate and vitamin B12 and risk of PD. PD patients had lower level of vitamin B12 and similar level of folate compared with controls. Dietary intake of vitamin B6 exhibited preventive effect of developing PD based on the available data. As the number of included studies is limited, more studies are needed to confirm the findings and elucidate the underpinning underlying these associations. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/26343714/Associations_between_B_Vitamins_and_Parkinson's_Disease_ L2 - http://www.mdpi.com/resolver?pii=nu7095333 DB - PRIME DP - Unbound Medicine ER -