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Exposure to bisphenol A during pregnancy and child neuropsychological development in the INMA-Sabadell cohort.
Environ Res. 2015 Oct; 142:671-9.ER

Abstract

BACKGROUND

Bisphenol A (BPA) may be a neurodevelopmental toxicant, but evidence is not consistent in terms of the sex-specific patterns of the associations and the specific behavioral or cognitive domains most affected.

OBJECTIVE

To examine the effects of prenatal BPA exposure on cognitive, psychomotor, and behavioral development in 438 children at 1, 4 and 7 years of age.

METHODS

BPA was measured in spot urine samples collected in trimester 1 and 3 of pregnancy from women participating in the INMA-Sabadell birth cohort study. Cognitive and psychomotor development was assessed at 1 and 4 years using psychologist-based scales. Attention deficit hyperactivity disorder (ADHD) symptoms and other behavioral problems were assessed at 4 years by teachers and at 7 years by parents using questionnaire-based rating scales.

RESULTS

Geometric mean creatinine-adjusted BPA concentration of the averaged samples was 2.6 μg/g creatinine. BPA exposure was not associated with the cognitive scores or their subscales at 1 and 4 years of age. At 1 year of age, exposure in the highest tertile of BPA concentrations was associated with a reduction of psychomotor scores (T3 vs T1 β=-4.28 points, 95% CI: -8.15, -0.41), but there was no association with psychomotor outcomes at 4 years. At 4 years, BPA exposure was associated with an increased risk of ADHD-hyperactivity symptoms (Incidence Rate Ratio (IRR) per log10 μg BPA/g creatinine increase=1.72; 1.08, 2.73) and this association was stronger in boys than in girls. Further, boys had an increased risk of ADHD-inattention symptoms whereas girls showed a reduced risk (p for interaction <0.1). At 7 years, these associations were not statistically significant nor were any other behavioral problems.

CONCLUSIONS

These results suggest that prenatal BPA exposure does not affect cognitive development up to age 4 years. Associations are observed with psychomotor development and ADHD-related symptoms at early ages, but these do not appear to persist until later ages.

Authors+Show Affiliations

Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. Electronic address: mcasas@creal.cat.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Department of Genes and Environment, Division of Epidemiology, Norwegian Institute of Public Health, Oslo, Norway.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Unitat Docent de Medicina Preventiva i Salut Publica H. Mar-UPF-ASPB, Barcelona, Spain; IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain; Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, MA, US.Department of Analytical Chemistry, University of Cordoba, Cordoba, Spain.Department of Analytical Chemistry, University of Cordoba, Cordoba, Spain.Department of Analytical Chemistry, University of Cordoba, Cordoba, Spain.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain; Universitat Pompeu Fabra (UPF), Barcelona, Spain; CIBER Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26343751

Citation

Casas, Maribel, et al. "Exposure to Bisphenol a During Pregnancy and Child Neuropsychological Development in the INMA-Sabadell Cohort." Environmental Research, vol. 142, 2015, pp. 671-9.
Casas M, Forns J, Martínez D, et al. Exposure to bisphenol A during pregnancy and child neuropsychological development in the INMA-Sabadell cohort. Environ Res. 2015;142:671-9.
Casas, M., Forns, J., Martínez, D., Avella-García, C., Valvi, D., Ballesteros-Gómez, A., Luque, N., Rubio, S., Julvez, J., Sunyer, J., & Vrijheid, M. (2015). Exposure to bisphenol A during pregnancy and child neuropsychological development in the INMA-Sabadell cohort. Environmental Research, 142, 671-9. https://doi.org/10.1016/j.envres.2015.07.024
Casas M, et al. Exposure to Bisphenol a During Pregnancy and Child Neuropsychological Development in the INMA-Sabadell Cohort. Environ Res. 2015;142:671-9. PubMed PMID: 26343751.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Exposure to bisphenol A during pregnancy and child neuropsychological development in the INMA-Sabadell cohort. AU - Casas,Maribel, AU - Forns,Joan, AU - Martínez,David, AU - Avella-García,Claudia, AU - Valvi,Damaskini, AU - Ballesteros-Gómez,Ana, AU - Luque,Noelia, AU - Rubio,Soledad, AU - Julvez,Jordi, AU - Sunyer,Jordi, AU - Vrijheid,Martine, PY - 2015/05/11/received PY - 2015/07/16/revised PY - 2015/07/31/accepted PY - 2015/9/8/entrez PY - 2015/9/8/pubmed PY - 2016/2/2/medline KW - ADHD KW - Behavior KW - Birth cohort KW - Bisphenol A KW - Cognitive development SP - 671 EP - 9 JF - Environmental research JO - Environ. Res. VL - 142 N2 - BACKGROUND: Bisphenol A (BPA) may be a neurodevelopmental toxicant, but evidence is not consistent in terms of the sex-specific patterns of the associations and the specific behavioral or cognitive domains most affected. OBJECTIVE: To examine the effects of prenatal BPA exposure on cognitive, psychomotor, and behavioral development in 438 children at 1, 4 and 7 years of age. METHODS: BPA was measured in spot urine samples collected in trimester 1 and 3 of pregnancy from women participating in the INMA-Sabadell birth cohort study. Cognitive and psychomotor development was assessed at 1 and 4 years using psychologist-based scales. Attention deficit hyperactivity disorder (ADHD) symptoms and other behavioral problems were assessed at 4 years by teachers and at 7 years by parents using questionnaire-based rating scales. RESULTS: Geometric mean creatinine-adjusted BPA concentration of the averaged samples was 2.6 μg/g creatinine. BPA exposure was not associated with the cognitive scores or their subscales at 1 and 4 years of age. At 1 year of age, exposure in the highest tertile of BPA concentrations was associated with a reduction of psychomotor scores (T3 vs T1 β=-4.28 points, 95% CI: -8.15, -0.41), but there was no association with psychomotor outcomes at 4 years. At 4 years, BPA exposure was associated with an increased risk of ADHD-hyperactivity symptoms (Incidence Rate Ratio (IRR) per log10 μg BPA/g creatinine increase=1.72; 1.08, 2.73) and this association was stronger in boys than in girls. Further, boys had an increased risk of ADHD-inattention symptoms whereas girls showed a reduced risk (p for interaction <0.1). At 7 years, these associations were not statistically significant nor were any other behavioral problems. CONCLUSIONS: These results suggest that prenatal BPA exposure does not affect cognitive development up to age 4 years. Associations are observed with psychomotor development and ADHD-related symptoms at early ages, but these do not appear to persist until later ages. SN - 1096-0953 UR - https://www.unboundmedicine.com/medline/citation/26343751/Exposure_to_bisphenol_A_during_pregnancy_and_child_neuropsychological_development_in_the_INMA_Sabadell_cohort_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0013-9351(15)30044-X DB - PRIME DP - Unbound Medicine ER -