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Chronically infected wild boar can transmit genotype 3 hepatitis E virus to domestic pigs.
Vet Microbiol. 2015 Oct 22; 180(1-2):15-21.VM

Abstract

Hepatitis E virus (HEV) causes acute hepatitis E in humans in developing countries, but sporadic and autochthonous cases do also occur in industrialized nations. In Europe, food-borne zoonotic transmission of genotype 3 (gt3) has been associated with the consumption of raw and undercooked products from domestic pig and wild boar. As shown recently, naturally acquired HEV gt3 replicates efficiently in experimentally infected wild boar and is transmissible from a wild boar to domestic pigs. Generally, following an acute infection swine suffer from a transient febrile illness and viremia in connection with fecal virus shedding. However, little is known about sub-acute or chronic HEV infections in swine, and how and where HEV survives the immune response. In this paper, we describe the incidental finding of a chronic HEVgt3 infection in two naturally infected European wild boar which were raised and housed at FLI over years. The wild boar displayed fecal HEV RNA excretion and viremia over nearly the whole observation period of more than five months. The animal had mounted a substantial antibody response, yet without initial clearance of the virus by the immune system. Further analysis indicated a subclinical course of HEV with no evidence of chronic hepatitis. Additionally, we could demonstrate that this chronic wild boar infection was still transmissible to domestic pigs, which were housed together with this animal. Sentinel pigs developed fecal virus shedding accompanied by seroconversion. Wild boar should therefore be considered as an important reservoir for transmission of HEV gt3 in Europe.

Authors+Show Affiliations

Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald-Insel Riems, Germany. Electronic address: josephine.schlosser@gmx.de.Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald-Insel Riems, Germany. Electronic address: arielvina.rodriguez@fli.bund.de.Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald-Insel Riems, Germany. Electronic address: christine.fast@fli.bund.de.Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald-Insel Riems, Germany. Electronic address: martin.groschup@fli.bund.de.Institute of Novel and Emerging Infectious Diseases, Friedrich-Loeffler-Institut, Suedufer 10, 17493 Greifswald-Insel Riems, Germany. Electronic address: martin.eiden@fli.bund.de.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26344041

Citation

Schlosser, Josephine, et al. "Chronically Infected Wild Boar Can Transmit Genotype 3 Hepatitis E Virus to Domestic Pigs." Veterinary Microbiology, vol. 180, no. 1-2, 2015, pp. 15-21.
Schlosser J, Vina-Rodriguez A, Fast C, et al. Chronically infected wild boar can transmit genotype 3 hepatitis E virus to domestic pigs. Vet Microbiol. 2015;180(1-2):15-21.
Schlosser, J., Vina-Rodriguez, A., Fast, C., Groschup, M. H., & Eiden, M. (2015). Chronically infected wild boar can transmit genotype 3 hepatitis E virus to domestic pigs. Veterinary Microbiology, 180(1-2), 15-21. https://doi.org/10.1016/j.vetmic.2015.08.022
Schlosser J, et al. Chronically Infected Wild Boar Can Transmit Genotype 3 Hepatitis E Virus to Domestic Pigs. Vet Microbiol. 2015 Oct 22;180(1-2):15-21. PubMed PMID: 26344041.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronically infected wild boar can transmit genotype 3 hepatitis E virus to domestic pigs. AU - Schlosser,Josephine, AU - Vina-Rodriguez,Ariel, AU - Fast,Christine, AU - Groschup,Martin H, AU - Eiden,Martin, Y1 - 2015/08/29/ PY - 2015/04/21/received PY - 2015/08/11/revised PY - 2015/08/27/accepted PY - 2015/9/8/entrez PY - 2015/9/8/pubmed PY - 2016/8/4/medline KW - Chronic hepatitis E KW - Chronic infection KW - Domestic pig KW - Genotype 3 KW - Hepatitis E virus KW - Transmission KW - Wild boar SP - 15 EP - 21 JF - Veterinary microbiology JO - Vet Microbiol VL - 180 IS - 1-2 N2 - Hepatitis E virus (HEV) causes acute hepatitis E in humans in developing countries, but sporadic and autochthonous cases do also occur in industrialized nations. In Europe, food-borne zoonotic transmission of genotype 3 (gt3) has been associated with the consumption of raw and undercooked products from domestic pig and wild boar. As shown recently, naturally acquired HEV gt3 replicates efficiently in experimentally infected wild boar and is transmissible from a wild boar to domestic pigs. Generally, following an acute infection swine suffer from a transient febrile illness and viremia in connection with fecal virus shedding. However, little is known about sub-acute or chronic HEV infections in swine, and how and where HEV survives the immune response. In this paper, we describe the incidental finding of a chronic HEVgt3 infection in two naturally infected European wild boar which were raised and housed at FLI over years. The wild boar displayed fecal HEV RNA excretion and viremia over nearly the whole observation period of more than five months. The animal had mounted a substantial antibody response, yet without initial clearance of the virus by the immune system. Further analysis indicated a subclinical course of HEV with no evidence of chronic hepatitis. Additionally, we could demonstrate that this chronic wild boar infection was still transmissible to domestic pigs, which were housed together with this animal. Sentinel pigs developed fecal virus shedding accompanied by seroconversion. Wild boar should therefore be considered as an important reservoir for transmission of HEV gt3 in Europe. SN - 1873-2542 UR - https://www.unboundmedicine.com/medline/citation/26344041/Chronically_infected_wild_boar_can_transmit_genotype_3_hepatitis_E_virus_to_domestic_pigs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-1135(15)30011-0 DB - PRIME DP - Unbound Medicine ER -