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Microalbuminuria is associated with long term poor glycemic control in adolescent insulin dependent diabetics.
Diabetes Res 1989; 12(2):71-4DR

Abstract

In insulin dependent diabetics microalbuminuria predicts proteinuria which is associated with an extremely high relative mortality rate. We studied the connection between long term blood glucose levels and microalbuminuria. One hundred and twenty-seven patients between 10-20 yr of age were screened for microalbuminuria. Twenty patients with both persistent microalbuminuria (greater than 15 micrograms/min albumin in at least two out of three timed overnight urine samples) and greater than 4 measurements of glycosylated hemoglobin A1 yearly for 5 yr, were included in the study. These 20 patients were matched with respect to sex, age and duration of diabetes against the normoalbuminuric diabetics. The patients with microalbuminuria had significantly higher mean 5-yr glycosylated hemoglobin A1 values than those with normoalbuminuria, 12.4 and 10.5% respectively (p less than 0.01). The data indicate a logarithmic association between mean 5 yr glycosylated hemoglobin A1 values and the urinary albumin excretion rate. The study points to a strong association between long term blood glucose levels and microalbuminuria in adolescents.

Authors+Show Affiliations

Pediatric Department, Aker Hospital, Oslo, Norway.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2634509

Citation

Bangstad, H J., et al. "Microalbuminuria Is Associated With Long Term Poor Glycemic Control in Adolescent Insulin Dependent Diabetics." Diabetes Research (Edinburgh, Scotland), vol. 12, no. 2, 1989, pp. 71-4.
Bangstad HJ, Hanssen KF, Dahl-Jørgensen K, et al. Microalbuminuria is associated with long term poor glycemic control in adolescent insulin dependent diabetics. Diabetes Res. 1989;12(2):71-4.
Bangstad, H. J., Hanssen, K. F., Dahl-Jørgensen, K., & Aagenaes, O. (1989). Microalbuminuria is associated with long term poor glycemic control in adolescent insulin dependent diabetics. Diabetes Research (Edinburgh, Scotland), 12(2), pp. 71-4.
Bangstad HJ, et al. Microalbuminuria Is Associated With Long Term Poor Glycemic Control in Adolescent Insulin Dependent Diabetics. Diabetes Res. 1989;12(2):71-4. PubMed PMID: 2634509.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microalbuminuria is associated with long term poor glycemic control in adolescent insulin dependent diabetics. AU - Bangstad,H J, AU - Hanssen,K F, AU - Dahl-Jørgensen,K, AU - Aagenaes,O, PY - 1989/10/1/pubmed PY - 1989/10/1/medline PY - 1989/10/1/entrez SP - 71 EP - 4 JF - Diabetes research (Edinburgh, Scotland) JO - Diabetes Res. VL - 12 IS - 2 N2 - In insulin dependent diabetics microalbuminuria predicts proteinuria which is associated with an extremely high relative mortality rate. We studied the connection between long term blood glucose levels and microalbuminuria. One hundred and twenty-seven patients between 10-20 yr of age were screened for microalbuminuria. Twenty patients with both persistent microalbuminuria (greater than 15 micrograms/min albumin in at least two out of three timed overnight urine samples) and greater than 4 measurements of glycosylated hemoglobin A1 yearly for 5 yr, were included in the study. These 20 patients were matched with respect to sex, age and duration of diabetes against the normoalbuminuric diabetics. The patients with microalbuminuria had significantly higher mean 5-yr glycosylated hemoglobin A1 values than those with normoalbuminuria, 12.4 and 10.5% respectively (p less than 0.01). The data indicate a logarithmic association between mean 5 yr glycosylated hemoglobin A1 values and the urinary albumin excretion rate. The study points to a strong association between long term blood glucose levels and microalbuminuria in adolescents. SN - 0265-5985 UR - https://www.unboundmedicine.com/medline/citation/2634509/Microalbuminuria_is_associated_with_long_term_poor_glycemic_control_in_adolescent_insulin_dependent_diabetics_ L2 - https://medlineplus.gov/bloodsugar.html DB - PRIME DP - Unbound Medicine ER -