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The relation between celiac disease, nonceliac gluten sensitivity and irritable bowel syndrome.
Nutr J 2015; 14:92NJ

Abstract

Wheat products make a substantial contribution to the dietary intake of many people worldwide. Despite the many beneficial aspects of consuming wheat products, it is also responsible for several diseases such as celiac disease (CD), wheat allergy, and nonceliac gluten sensitivity (NCGS). CD and irritable bowel syndrome (IBS) patients have similar gastrointestinal symptoms, which can result in CD patients being misdiagnosed as having IBS. Therefore, CD should be excluded in IBS patients. A considerable proportion of CD patients suffer from IBS symptoms despite adherence to a gluten-free diet (GFD). The inflammation caused by gluten intake may not completely subside in some CD patients. It is not clear that gluten triggers the symptoms in NCGS, but there is compelling evidence that carbohydrates (fructans and galactans) in wheat does. It is likely that NCGS patients are a group of self-diagnosed IBS patients who self-treat by adhering to a GFD.

Authors+Show Affiliations

Section for Gastroenterology, Department of Medicine, Stord Hospital, Stord, Norway. magdy.el-salhy@helse-fonna.no. Section for Neuroendocrine Gastroenterology, Division of Gastroenterology, Department of Clinical Medicine, University of Bergen, Bergen, Norway. magdy.el-salhy@helse-fonna.no. National Centre for Functional Gastrointestinal Disorders, Department of Medicine, Haukeland University Hospital, Bergen, Norway. magdy.el-salhy@helse-fonna.no.Section for Neuroendocrine Gastroenterology, Division of Gastroenterology, Department of Clinical Medicine, University of Bergen, Bergen, Norway. Jan.hatlebakk@helse-bergen.no. National Centre for Functional Gastrointestinal Disorders, Department of Medicine, Haukeland University Hospital, Bergen, Norway. Jan.hatlebakk@helse-bergen.no.Section for Neuroendocrine Gastroenterology, Division of Gastroenterology, Department of Clinical Medicine, University of Bergen, Bergen, Norway. Odd.helge.gilja@helse-bergen.no. National Centre for Functional Gastrointestinal Disorders, Department of Medicine, Haukeland University Hospital, Bergen, Norway. Odd.helge.gilja@helse-bergen.no. National Centre for Ultrasound in Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway. Odd.helge.gilja@helse-bergen.no.Section for Neuroendocrine Gastroenterology, Division of Gastroenterology, Department of Clinical Medicine, University of Bergen, Bergen, Norway. Trygve.hausken@helse-bergen.no. National Centre for Functional Gastrointestinal Disorders, Department of Medicine, Haukeland University Hospital, Bergen, Norway. Trygve.hausken@helse-bergen.no. National Centre for Ultrasound in Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway. Trygve.hausken@helse-bergen.no.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

26345589

Citation

El-Salhy, Magdy, et al. "The Relation Between Celiac Disease, Nonceliac Gluten Sensitivity and Irritable Bowel Syndrome." Nutrition Journal, vol. 14, 2015, p. 92.
El-Salhy M, Hatlebakk JG, Gilja OH, et al. The relation between celiac disease, nonceliac gluten sensitivity and irritable bowel syndrome. Nutr J. 2015;14:92.
El-Salhy, M., Hatlebakk, J. G., Gilja, O. H., & Hausken, T. (2015). The relation between celiac disease, nonceliac gluten sensitivity and irritable bowel syndrome. Nutrition Journal, 14, p. 92. doi:10.1186/s12937-015-0080-6.
El-Salhy M, et al. The Relation Between Celiac Disease, Nonceliac Gluten Sensitivity and Irritable Bowel Syndrome. Nutr J. 2015 Sep 7;14:92. PubMed PMID: 26345589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relation between celiac disease, nonceliac gluten sensitivity and irritable bowel syndrome. AU - El-Salhy,Magdy, AU - Hatlebakk,Jan Gunnar, AU - Gilja,Odd Helge, AU - Hausken,Trygve, Y1 - 2015/09/07/ PY - 2015/05/25/received PY - 2015/08/28/accepted PY - 2015/9/9/entrez PY - 2015/9/9/pubmed PY - 2016/6/9/medline SP - 92 EP - 92 JF - Nutrition journal JO - Nutr J VL - 14 N2 - Wheat products make a substantial contribution to the dietary intake of many people worldwide. Despite the many beneficial aspects of consuming wheat products, it is also responsible for several diseases such as celiac disease (CD), wheat allergy, and nonceliac gluten sensitivity (NCGS). CD and irritable bowel syndrome (IBS) patients have similar gastrointestinal symptoms, which can result in CD patients being misdiagnosed as having IBS. Therefore, CD should be excluded in IBS patients. A considerable proportion of CD patients suffer from IBS symptoms despite adherence to a gluten-free diet (GFD). The inflammation caused by gluten intake may not completely subside in some CD patients. It is not clear that gluten triggers the symptoms in NCGS, but there is compelling evidence that carbohydrates (fructans and galactans) in wheat does. It is likely that NCGS patients are a group of self-diagnosed IBS patients who self-treat by adhering to a GFD. SN - 1475-2891 UR - https://www.unboundmedicine.com/medline/citation/26345589/full_citation L2 - https://nutritionj.biomedcentral.com/articles/10.1186/s12937-015-0080-6 DB - PRIME DP - Unbound Medicine ER -