Tags

Type your tag names separated by a space and hit enter

Antioxidant and in vitro anticancer activities of phenolics isolated from sugar beet molasses.
BMC Complement Altern Med. 2015 Sep 07; 15:313.BC

Abstract

BACKGROUND

In the present study, the phenolic compounds were prepared using ultrasonic-aid extraction from sugar beet molasses (SBM).

METHODS

Gallic acid (GA), cyanidin-3-O-glucoside chloride (CGC) and epicatechin (EP) were produced after column chromatography from the extraction, and further detected using NMR, QTOF-MS and ESI-MS/MS.

RESULTS

The three compounds exhibited strong antioxidant activities including DPPH radical scavenging activities, ABTS radical scavenging activities and ORAC values. GA showed the strongest antioxidant activity. Antitumor activities significantly increased in a dose-dependent manner. In particular, the CGC had growth inhibitory activities of 94.86, 87.27 and 67.13% against the human colon (CACO-2), hepatocellular (HepG2) and breast (MCF-7) carcinoma cell lines, respectively, at the highest concentration of 400 μg/mL of the extracts. These results suggest that the three compounds are key chemical compositions valuable for preparing functional foods in the food industry.

CONCLUSIONS

The results suggested that SBM is a natural source of antioxidant and antitumor agents for preparing functional foods.

Links

PMC Free PDF

Authors+Show Affiliations

Chen M
College of Light Industry and Food Sciences, South China University of Technology, 381 Wushan road, Guangzhou, 510640, China.
Meng H
College of Light Industry and Food Sciences, South China University of Technology, 381 Wushan road, Guangzhou, 510640, China.
Zhao Y
College of Light Industry and Food Sciences, South China University of Technology, 381 Wushan road, Guangzhou, 510640, China.
Chen F
College of Light Industry and Food Sciences, South China University of Technology, 381 Wushan road, Guangzhou, 510640, China.
Yu S
College of Light Industry and Food Sciences, South China University of Technology, 381 Wushan road, Guangzhou, 510640, China. shujuanyu8@gmail.com. Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou, 510640, China. shujuanyu8@gmail.com.

MeSH

Antineoplastic AgentsAntioxidantsBeta vulgarisCaco-2 CellsCell ProliferationHeLa CellsHumansMolassesPlant Extracts

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

26347338

Citation

Chen, Mingshun, et al. "Antioxidant and in Vitro Anticancer Activities of Phenolics Isolated From Sugar Beet Molasses." BMC Complementary and Alternative Medicine, vol. 15, 2015, p. 313.
Chen M, Meng H, Zhao Y, et al. Antioxidant and in vitro anticancer activities of phenolics isolated from sugar beet molasses. BMC Complement Altern Med. 2015;15:313.
Chen, M., Meng, H., Zhao, Y., Chen, F., & Yu, S. (2015). Antioxidant and in vitro anticancer activities of phenolics isolated from sugar beet molasses. BMC Complementary and Alternative Medicine, 15, 313. https://doi.org/10.1186/s12906-015-0847-5
Chen M, et al. Antioxidant and in Vitro Anticancer Activities of Phenolics Isolated From Sugar Beet Molasses. BMC Complement Altern Med. 2015 Sep 7;15:313. PubMed PMID: 26347338.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and in vitro anticancer activities of phenolics isolated from sugar beet molasses. AU - Chen,Mingshun, AU - Meng,Hecheng, AU - Zhao,Yi, AU - Chen,Fuquan, AU - Yu,Shujuan, Y1 - 2015/09/07/ PY - 2015/05/19/received PY - 2015/09/02/accepted PY - 2015/9/9/entrez PY - 2015/9/9/pubmed PY - 2016/3/10/medline SP - 313 EP - 313 JF - BMC complementary and alternative medicine JO - BMC Complement Altern Med VL - 15 N2 - BACKGROUND: In the present study, the phenolic compounds were prepared using ultrasonic-aid extraction from sugar beet molasses (SBM). METHODS: Gallic acid (GA), cyanidin-3-O-glucoside chloride (CGC) and epicatechin (EP) were produced after column chromatography from the extraction, and further detected using NMR, QTOF-MS and ESI-MS/MS. RESULTS: The three compounds exhibited strong antioxidant activities including DPPH radical scavenging activities, ABTS radical scavenging activities and ORAC values. GA showed the strongest antioxidant activity. Antitumor activities significantly increased in a dose-dependent manner. In particular, the CGC had growth inhibitory activities of 94.86, 87.27 and 67.13% against the human colon (CACO-2), hepatocellular (HepG2) and breast (MCF-7) carcinoma cell lines, respectively, at the highest concentration of 400 μg/mL of the extracts. These results suggest that the three compounds are key chemical compositions valuable for preparing functional foods in the food industry. CONCLUSIONS: The results suggested that SBM is a natural source of antioxidant and antitumor agents for preparing functional foods. SN - 1472-6882 UR - https://www.unboundmedicine.com/medline/citation/26347338/Antioxidant_and_in_vitro_anticancer_activities_of_phenolics_isolated_from_sugar_beet_molasses_ DB - PRIME DP - Unbound Medicine ER -