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Effect of fluoxetine and resveratrol on testicular functions and oxidative stress in a rat model of chronic mild stress-induced depression.
J Physiol Pharmacol. 2015 Aug; 66(4):515-27.JP

Abstract

Our objective was to investigate the effects of chronic unpredictable mild stress (CUMS) with or without selective serotonin reuptake inhibitor (fluoxetine) and anti-oxidant (resveratrol) on testicular functions and oxidative stress in rats. Fifty male rats were divided into 2 groups; control and CUMS. CUMS group was further subdivided into 4 subgroups administered water, fluoxetine, resveratrol and both. Sucrose intake, body weight gain, serum corticosterone, serotonin and testosterone levels, sperm count and motility, testicular malondialdehyde, superoxide dismutase (SOD), catalase, glutathione (GSH), and gene expression of steroidogenic acute-regulatory (StAR) protein and cytochrome P450 side chain cleavage (P450scc) enzyme were evaluated. CUMS decreased sucrose intake, weight gain, anti-oxidants (SOD, catalase, GSH), testosterone, serotonin, StAR and cytochrome P450scc gene expression, sperm count and motility and increased malondialdehyde and corticosterone. Fluoxetine increased malondialdehyde, sucrose intake, weight gain, serotonin and decreased anti-oxidants, StAR and cytochrome P450scc gene expression, sperm count and motility, testosterone, corticosterone in stressed rats. Administration of resveratrol increased anti-oxidants, sucrose intake, weight gain, serotonin, StAR and cytochrome P450scc gene expression, testosterone, sperm count and motility, and decreased malondialdehyde and corticosterone in stressed rats with or without fluoxetine. In conclusion, CUMS induces testicular dysfunctions and oxidative stress. While treatment of CUMS rats with fluoxetine decreases the depressive behavior, it causes further worsening of testicular dysfunctions and oxidative stress. Administration of resveratrol improves testicular dysfunctions and oxidative stress that are caused by CUMS and further worsened by fluoxetine treatment.

Authors+Show Affiliations

Medical Physiology Department, Faculty of Medicine, Mansoura University, Egypt. sakr_doctor@yahoo.com. Medical Physiology Department, College of Medicine, King Khalid University, Saudi Arabia.Medical Physiology Department, Faculty of Medicine, Mansoura University, Egypt.Medical Biochemistry and Molecular Biology Department, Faculty of Medicine, Mansoura University, Egypt.Medical Histology and Cell Biology Department, Faculty of Medicine, Mansoura University, Egypt.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

26348076

Citation

Sakr, H F., et al. "Effect of Fluoxetine and Resveratrol On Testicular Functions and Oxidative Stress in a Rat Model of Chronic Mild Stress-induced Depression." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 66, no. 4, 2015, pp. 515-27.
Sakr HF, Abbas AM, Elsamanoudy AZ, et al. Effect of fluoxetine and resveratrol on testicular functions and oxidative stress in a rat model of chronic mild stress-induced depression. J Physiol Pharmacol. 2015;66(4):515-27.
Sakr, H. F., Abbas, A. M., Elsamanoudy, A. Z., & Ghoneim, F. M. (2015). Effect of fluoxetine and resveratrol on testicular functions and oxidative stress in a rat model of chronic mild stress-induced depression. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 66(4), 515-27.
Sakr HF, et al. Effect of Fluoxetine and Resveratrol On Testicular Functions and Oxidative Stress in a Rat Model of Chronic Mild Stress-induced Depression. J Physiol Pharmacol. 2015;66(4):515-27. PubMed PMID: 26348076.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of fluoxetine and resveratrol on testicular functions and oxidative stress in a rat model of chronic mild stress-induced depression. AU - Sakr,H F, AU - Abbas,A M, AU - Elsamanoudy,A Z, AU - Ghoneim,F M, PY - 2015/01/27/received PY - 2015/07/01/accepted PY - 2015/9/9/entrez PY - 2015/9/9/pubmed PY - 2016/6/9/medline SP - 515 EP - 27 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J. Physiol. Pharmacol. VL - 66 IS - 4 N2 - Our objective was to investigate the effects of chronic unpredictable mild stress (CUMS) with or without selective serotonin reuptake inhibitor (fluoxetine) and anti-oxidant (resveratrol) on testicular functions and oxidative stress in rats. Fifty male rats were divided into 2 groups; control and CUMS. CUMS group was further subdivided into 4 subgroups administered water, fluoxetine, resveratrol and both. Sucrose intake, body weight gain, serum corticosterone, serotonin and testosterone levels, sperm count and motility, testicular malondialdehyde, superoxide dismutase (SOD), catalase, glutathione (GSH), and gene expression of steroidogenic acute-regulatory (StAR) protein and cytochrome P450 side chain cleavage (P450scc) enzyme were evaluated. CUMS decreased sucrose intake, weight gain, anti-oxidants (SOD, catalase, GSH), testosterone, serotonin, StAR and cytochrome P450scc gene expression, sperm count and motility and increased malondialdehyde and corticosterone. Fluoxetine increased malondialdehyde, sucrose intake, weight gain, serotonin and decreased anti-oxidants, StAR and cytochrome P450scc gene expression, sperm count and motility, testosterone, corticosterone in stressed rats. Administration of resveratrol increased anti-oxidants, sucrose intake, weight gain, serotonin, StAR and cytochrome P450scc gene expression, testosterone, sperm count and motility, and decreased malondialdehyde and corticosterone in stressed rats with or without fluoxetine. In conclusion, CUMS induces testicular dysfunctions and oxidative stress. While treatment of CUMS rats with fluoxetine decreases the depressive behavior, it causes further worsening of testicular dysfunctions and oxidative stress. Administration of resveratrol improves testicular dysfunctions and oxidative stress that are caused by CUMS and further worsened by fluoxetine treatment. SN - 1899-1505 UR - https://www.unboundmedicine.com/medline/citation/26348076/Effect_of_fluoxetine_and_resveratrol_on_testicular_functions_and_oxidative_stress_in_a_rat_model_of_chronic_mild_stress_induced_depression_ L2 - http://www.jpp.krakow.pl/journal/archive/08_15/pdf/515_08_15_article.pdf DB - PRIME DP - Unbound Medicine ER -